Propofol postconditioning protects H9c2 cells from hypoxia/reoxygenation injury by inducing autophagy via the SAPK/JNK pathway
Propofol postconditioning (P-PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation...
Uloženo v:
| Vydáno v: | Molecular medicine reports Ročník 17; číslo 3; s. 4573 - 4580 |
|---|---|
| Hlavní autoři: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Greece
D.A. Spandidos
01.03.2018
Spandidos Publications Spandidos Publications UK Ltd |
| Témata: | |
| ISSN: | 1791-2997, 1791-3004, 1791-3004 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Propofol postconditioning (P-PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart-derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P-PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c-Jun N-terminal kinase (JNK) in cells treated with P-PostC with or without co-treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P-PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P-PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3-methyladenine treatment diminished the cardioprotective effects of P-PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress-activated protein kinase/JNK survival pathway may be partly involved in P-PostC-induced autophagy. |
|---|---|
| AbstractList | Propofol postconditioning (P-PostC) offers cardio protection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart-derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P-PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c-Jun N-terminal kinase (JNK) in cells treated with P-PostC with or without co-treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P-PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P-PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3-methyladenine treatment diminished the cardioprotective effects of P-PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress-activated protein kinase/JNK survival pathway may be partly involved in P-PostC-induced autophagy. Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P‑PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart‑derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P‑PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c‑Jun N‑terminal kinase (JNK) in cells treated with P‑PostC with or without co‑treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P‑PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P‑PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3‑methyladenine treatment diminished the cardioprotective effects of P‑PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress‑activated protein kinase/JNK survival pathway may be partly involved in P‑PostC‑induced autophagy.Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P‑PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart‑derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P‑PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c‑Jun N‑terminal kinase (JNK) in cells treated with P‑PostC with or without co‑treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P‑PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P‑PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3‑methyladenine treatment diminished the cardioprotective effects of P‑PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress‑activated protein kinase/JNK survival pathway may be partly involved in P‑PostC‑induced autophagy. Propofol postconditioning (P-PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart-derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P-PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c-Jun N-terminal kinase (JNK) in cells treated with P-PostC with or without co-treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P-PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P-PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3-methyladenine treatment diminished the cardioprotective effects of P-PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress-activated protein kinase/JNK survival pathway may be partly involved in P-PostC-induced autophagy. Propofol postconditioning (P-PostC) offers cardio protection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P-PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart-derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P-PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c-Jun N-terminal kinase (JNK) in cells treated with P-PostC with or without co-treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P-PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P-PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3-methyladenine treatment diminished the cardioprotective effects of P-PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress-activated protein kinase/JNK survival pathway may be partly involved in P-PostC-induced autophagy. Key words: myocardial ischemia, cardioprotection, ischemic postconditioning, autophagy Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion injury. The present study aimed to examine the effects of P‑PostC on the induction of autophagy and its potential roles in hypoxia/reoxygenation (H/R) injury. Rat heart‑derived H9c2 cells were exposed to H/R, comprising 6 h of hypoxia followed by 4 h of reoxygenation, as well as postconditioning with various concentrations of propofol at the onset of reperfusion. Lactate dehydrogenase (LDH) activity and the rate of cell apoptosis were measured to evaluate the degree of cardiomyocyte H/R injury. The induction of autophagy in myocytes subjected to H/R injury and P‑PostC was detected by western blotting and immunofluorescence. Furthermore, the activation of c‑Jun N‑terminal kinase (JNK) in cells treated with P‑PostC with or without co‑treatment with SP600125, an inhibitor of JNK, was also determined by western blotting. P‑PostC reduced the activity of LDH in the culture medium and the percentage of apoptotic cells compared with cells in the untreated H/R group. In addition, P‑PostC induced autophagy and promoted survival signaling in H9c2 cardiac myoblast cells. The inhibition of autophagy by 3‑methyladenine treatment diminished the cardioprotective effects of P‑PostC. These results indicated that propofol postconditioning promoted cell survival through the induction of autophagy in H9c2 cardiac cells, and that the stress‑activated protein kinase/JNK survival pathway may be partly involved in P‑PostC‑induced autophagy. |
| Audience | Academic |
| Author | Lou, Jing-Sheng Sun, Li Zhang, Xuan Jiang, Yu-Ge Li, Hao Shi, Xue-Yin Xu, Long-He Mi, Wei-Dong Tan, Jian |
| Author_xml | – sequence: 1 givenname: Hao surname: Li fullname: Li, Hao organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 2 givenname: Xuan surname: Zhang fullname: Zhang, Xuan organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 3 givenname: Jian surname: Tan fullname: Tan, Jian organization: 2Department of Thoracic Surgery, PLA Army General Hospital, Beijing 100700, P.R. China – sequence: 4 givenname: Li surname: Sun fullname: Sun, Li organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 5 givenname: Long-He surname: Xu fullname: Xu, Long-He organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 6 givenname: Yu-Ge surname: Jiang fullname: Jiang, Yu-Ge organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 7 givenname: Jing-Sheng surname: Lou fullname: Lou, Jing-Sheng organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China – sequence: 8 givenname: Xue-Yin surname: Shi fullname: Shi, Xue-Yin organization: 3Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China – sequence: 9 givenname: Wei-Dong surname: Mi fullname: Mi, Wei-Dong organization: 1Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing 100853, P.R. China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29328382$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1ks2P1CAYxolZ437o0ash8aCXzvDRFjhuNquru9FN1DOhFGaYtKUC1e3Fv13qzGrcKBwg5Pc8wPs-p-Bo8IMB4DlGK8oFWfd9WBGE-YqXpHwETjATuKAIlUeHPRGCHYPTGHcI1RWpxBNwTAQlnHJyAn7cBj966zs4-pi0H1qXnB_csIFj8MnoFOGV0ARq03UR2uB7uJ1Hf-fUOhh_N2_MoBYFdMNuCjNs5rxrJ704qCn5cas2M_zmFExbAz-d316v33-4hqNK2-9qfgoeW9VF8-ywnoEvby4_X1wVNx_fvrs4vyl0WYlUsBo1DDeqbgSiqMW1EVprqlhrOataXpWGKoMrhCy3VAmlcMuMsqZl2OqG0TPweu-bP_V1MjHJ3sXlS2owfooSCy5qxAlZ0JcP0J2fwpBflylRMpqH-ENtVGekG6xPQenFVJ5XhJc1Y4hnavUPKs_W9C4X21iXz_8SvDhcPjW9aeUYXK_CLO8blgG6B3TwMQZjpXbpVwOys-skRnKJhcyxkEss5BKLrCoeqO6N_8e_2vNxVDkRrY-_BRksMCsQLcoq1-InsDXHIw |
| CitedBy_id | crossref_primary_10_1155_2021_3347949 crossref_primary_10_1186_s10020_018_0054_1 crossref_primary_10_1186_s40779_021_00353_0 crossref_primary_10_1007_s13577_018_00230_4 crossref_primary_10_4236_jbise_2025_188025 crossref_primary_10_4330_wjc_v16_i12_689 crossref_primary_10_3892_etm_2021_10615 |
| Cites_doi | 10.1016/j.biocel.2004.02.005 10.1016/S1534-5807(04)00099-1 10.1002/cbf.290020305 10.1161/01.CIR.74.5.1124 10.1177/1074248410370327 10.3892/ol.2013.1498 10.1016/S0076-6879(08)01415-8 10.1038/nrm2239 10.1126/science.290.5497.1717 10.1038/aps.2013.18 10.1016/j.jhep.2005.01.030 10.1097/EJA.0b013e32834296d5 10.1016/j.yjmcc.2006.03.428 10.1016/S0092-8674(00)00116-1 10.1152/ajpheart.01064.2002 10.1007/978-1-59745-157-4_4 10.3892/ijmm.2015.2130 10.1016/j.yjmcc.2008.01.010 10.4161/auto.5655 10.1016/j.brainres.2010.08.009 10.2174/1381612043382846 10.4161/auto.5638 10.1097/00000542-199803000-00005 10.4161/auto.2946 10.1586/14779072.3.6.1035 10.1007/s12265-010-9189-3 10.1242/jcs.026005 10.1002/(SICI)1097-4644(19980201)68:2<259::AID-JCB12>3.0.CO;2-A 10.1128/MCB.01453-06 10.4161/auto.5.1.7303 10.1038/ncb1192 10.1038/onc.2009.487 10.1152/ajpheart.00062.2006 10.1042/BSR20140141 |
| ContentType | Journal Article |
| Copyright | Copyright © 2018, Spandidos Publications COPYRIGHT 2018 Spandidos Publications Copyright Spandidos Publications UK Ltd. 2018 |
| Copyright_xml | – notice: Copyright © 2018, Spandidos Publications – notice: COPYRIGHT 2018 Spandidos Publications – notice: Copyright Spandidos Publications UK Ltd. 2018 |
| DBID | HUR AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8AO 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AN0 AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.3892/mmr.2018.8424 |
| DatabaseName | Spandidos CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland British Nursing Database ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central Korea Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database ProQuest Biological Science ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition British Nursing Index with Full Text ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Central Student MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1791-3004 |
| EndPage | 4580 |
| ExternalDocumentID | A528467708 29328382 10_3892_mmr_2018_8424 mmr-17-03-4573 |
| Genre | Journal Article |
| GeographicLocations | United States--US |
| GeographicLocations_xml | – name: United States--US |
| GroupedDBID | --- 0R~ 123 53G 7X7 88E 8AO 8FE 8FH 8FI 8FJ ABDBF ABJNI ABUWG ACGFS ACPRK ACUHS ADBBV AEGXH AENEX AFKRA AHMBA ALMA_UNASSIGNED_HOLDINGS AN0 BAWUL BBNVY BENPR BHPHI BNQBC BPHCQ BVXVI C45 CCPQU CS3 DIK DU5 EBS EJD F5P FRP FYUFA H13 HCIFZ HMCUK HUR HZ~ IAO IHR INH INR IPNFZ ITC LK8 M1P M7P O9- OK1 OVD PHGZM PHGZT PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PUEGO RIG TEORI TR2 UKHRP W2D AAYXX AFFHD CITATION ALIPV CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK AZQEC DWQXO GNUQQ K9. PKEHL PQEST PQUKI PRINS 7X8 |
| ID | FETCH-LOGICAL-c459t-760b71ba6b9030d16e9ccc3a7df875d854e3ae1500f8f3a9aa1d7eafed71fcb73 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 18 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000424400000145&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1791-2997 1791-3004 |
| IngestDate | Thu Sep 04 19:00:40 EDT 2025 Tue Oct 07 07:02:45 EDT 2025 Tue Nov 11 10:42:15 EST 2025 Tue Nov 04 17:31:38 EST 2025 Thu Apr 03 07:03:24 EDT 2025 Sat Nov 29 04:57:38 EST 2025 Tue Nov 18 22:27:33 EST 2025 Tue Sep 30 17:19:15 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 3 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c459t-760b71ba6b9030d16e9ccc3a7df875d854e3ae1500f8f3a9aa1d7eafed71fcb73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| OpenAccessLink | http://www.spandidos-publications.com/10.3892/mmr.2018.8424/download |
| PMID | 29328382 |
| PQID | 1994733339 |
| PQPubID | 2044955 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1989608227 proquest_journals_1994733339 gale_infotracmisc_A528467708 gale_infotracacademiconefile_A528467708 pubmed_primary_29328382 crossref_citationtrail_10_3892_mmr_2018_8424 crossref_primary_10_3892_mmr_2018_8424 spandidos_primary_mmr-17-03-4573 |
| PublicationCentury | 2000 |
| PublicationDate | 2018-03-01 |
| PublicationDateYYYYMMDD | 2018-03-01 |
| PublicationDate_xml | – month: 03 year: 2018 text: 2018-03-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Greece |
| PublicationPlace_xml | – name: Greece – name: Athens |
| PublicationTitle | Molecular medicine reports |
| PublicationTitleAlternate | Mol Med Rep |
| PublicationYear | 2018 |
| Publisher | D.A. Spandidos Spandidos Publications Spandidos Publications UK Ltd |
| Publisher_xml | – name: D.A. Spandidos – name: Spandidos Publications – name: Spandidos Publications UK Ltd |
| References | Yan, Dong, Xiong (b13-mmr-17-03-4573) 2013; 34 Uehara, Bennett, Sakata, Satoh, Bilter, Westwick, Brenner (b28-mmr-17-03-4573) 2005; 42 Shimizu, Konishi, Nishida, Mizuta, Nishina, Yamamoto, Tsujimoto (b29-mmr-17-03-4573) 2010; 29 Powell (b10-mmr-17-03-4573) 2006; 291 Klionsky, Emr (b8-mmr-17-03-4573) 2000; 290 Guo, Wang, Xu, Wang, Song (b17-mmr-17-03-4573) 2015; 35 Maiuri, Zalckvar, Kimchi, Kroemer (b32-mmr-17-03-4573) 2007; 8 Gustafsson, Gottlieb (b25-mmr-17-03-4573) 2008; 44 Vinten-Johansen, Zhao, Jiang, Zatta (b4-mmr-17-03-4573) 2005; 3 Song, Liu, Ma, Zhang, Jiang, Jiang (b18-mmr-17-03-4573) 2013; 6 Marik (b6-mmr-17-03-4573) 2004; 10 Shvets, Fas, Scherz-Shouval, Elazar (b16-mmr-17-03-4573) 2008; 121 Makoto, Hajime, Takashi (b22-mmr-17-03-4573) 2014; 2014 Matsui, Kyoi, Takagi, Hsu, Hariharan, Ago, Vatner, Sadoshima (b26-mmr-17-03-4573) 2008; 4 Murry, Jennings, Reimer (b2-mmr-17-03-4573) 1986; 74 Zhao, Corvera, Halkos, Kerendi, Wang, Guyton, Vinten-Johansen (b3-mmr-17-03-4573) 2003; 285 Zhou, Li, Jiang, Zhou (b14-mmr-17-03-4573) 2015; 35 Gustafsson, Gottlieb (b24-mmr-17-03-4573) 2008; 4 Davis (b27-mmr-17-03-4573) 2000; 103 Levine, Klionsky (b9-mmr-17-03-4573) 2004; 6 Zakeri, Melendez, Lockshin (b35-mmr-17-03-4573) 2008; 442 Gurusamy, Lekli, Gherghiceanu, Popescu, Das (b12-mmr-17-03-4573) 2009; 5 Shimizu, Kanaseki, Mizushima, Mizuta, Arakawa-Kobayashi, Thompson, Tsujimoto (b31-mmr-17-03-4573) 2004; 6 Huang, Yitzhaki, Perry, Liu, Giricz, Mentzer, Gottlieb (b34-mmr-17-03-4573) 2010; 3 Valentim, Laurence, Townsend, Carroll, Soond, Scarabelli, Knight, Latchman, Stephanou (b33-mmr-17-03-4573) 2006; 40 Dosenko, Nagibin, Tumanovska, Moibenko (b11-mmr-17-03-4573) 2006; 2 Wang, Yu, Zhang, Yang, Yu, Yan, Chen (b5-mmr-17-03-4573) 2010; 1357 Li, Tan, Zou, Huang, Shi (b7-mmr-17-03-4573) 2011; 28 Hoch, Haase, Schulze, Hagemann, Morano, Krause, Karczewski (b19-mmr-17-03-4573) 1998; 68 Danpure (b20-mmr-17-03-4573) 1984; 2 Dong, Undyala, Gottlieb, Mentzer, Przyklenk (b23-mmr-17-03-4573) 2010; 15 Tanida, Ueno, Kominami (b15-mmr-17-03-4573) 2008; 445 Mizushima (b21-mmr-17-03-4573) 2004; 36 Badner, Knill, Brown, Novick, Gelb (b1-mmr-17-03-4573) 1998; 88 Ogata, Hino, Saito, Morikawa, Kondo, Kanemoto, Murakami, Taniguchi, Tanii, Yoshinaga (b30-mmr-17-03-4573) 2006; 26 Zakeri (key20200713224356_b35-mmr-17-03-4573) 2008; 442 Wang (key20200713224356_b5-mmr-17-03-4573) 2010; 1357 Gurusamy (key20200713224356_b12-mmr-17-03-4573) 2009; 5 Uehara (key20200713224356_b28-mmr-17-03-4573) 2005; 42 Guo (key20200713224356_b17-mmr-17-03-4573) 2015; 35 Hoch (key20200713224356_b19-mmr-17-03-4573) 1998; 68 Gustafsson (key20200713224356_b24-mmr-17-03-4573) 2008; 4 Shvets (key20200713224356_b16-mmr-17-03-4573) 2008; 121 Makoto (key20200713224356_b22-mmr-17-03-4573) 2014; 2014 Powell (key20200713224356_b10-mmr-17-03-4573) 2006; 291 Matsui (key20200713224356_b26-mmr-17-03-4573) 2008; 4 Yan (key20200713224356_b13-mmr-17-03-4573) 2013; 34 Tanida (key20200713224356_b15-mmr-17-03-4573) 2008; 445 Davis (key20200713224356_b27-mmr-17-03-4573) 2000; 103 Valentim (key20200713224356_b33-mmr-17-03-4573) 2006; 40 Zhao (key20200713224356_b3-mmr-17-03-4573) 2003; 285 Shimizu (key20200713224356_b31-mmr-17-03-4573) 2004; 6 Maiuri (key20200713224356_b32-mmr-17-03-4573) 2007; 8 Klionsky (key20200713224356_b8-mmr-17-03-4573) 2000; 290 Li (key20200713224356_b7-mmr-17-03-4573) 2011; 28 Song (key20200713224356_b18-mmr-17-03-4573) 2013; 6 Gustafsson (key20200713224356_b25-mmr-17-03-4573) 2008; 44 Danpure (key20200713224356_b20-mmr-17-03-4573) 1984; 2 Ogata (key20200713224356_b30-mmr-17-03-4573) 2006; 26 Huang (key20200713224356_b34-mmr-17-03-4573) 2010; 3 Marik (key20200713224356_b6-mmr-17-03-4573) 2004; 10 Mizushima (key20200713224356_b21-mmr-17-03-4573) 2004; 36 Dosenko (key20200713224356_b11-mmr-17-03-4573) 2006; 2 Levine (key20200713224356_b9-mmr-17-03-4573) 2004; 6 Zhou (key20200713224356_b14-mmr-17-03-4573) 2015; 35 Dong (key20200713224356_b23-mmr-17-03-4573) 2010; 15 Vinten-Johansen (key20200713224356_b4-mmr-17-03-4573) 2005; 3 Badner (key20200713224356_b1-mmr-17-03-4573) 1998; 88 Shimizu (key20200713224356_b29-mmr-17-03-4573) 2010; 29 Murry (key20200713224356_b2-mmr-17-03-4573) 1986; 74 |
| References_xml | – volume: 36 start-page: 2491 year: 2004 end-page: 2502 ident: b21-mmr-17-03-4573 article-title: Methods for monitoring autophagy publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2004.02.005 – volume: 6 start-page: 463 year: 2004 end-page: 477 ident: b9-mmr-17-03-4573 article-title: Development by self-digestion: Molecular mechanisms and biological functions of autophagy publication-title: Dev Cell doi: 10.1016/S1534-5807(04)00099-1 – volume: 2 start-page: 144 year: 1984 end-page: 148 ident: b20-mmr-17-03-4573 article-title: Lactate dehydrogenase and cell injury publication-title: Cell Biochem Funct doi: 10.1002/cbf.290020305 – volume: 74 start-page: 1124 year: 1986 end-page: 1136 ident: b2-mmr-17-03-4573 article-title: Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium publication-title: Circulation doi: 10.1161/01.CIR.74.5.1124 – volume: 15 start-page: 220 year: 2010 end-page: 230 ident: b23-mmr-17-03-4573 article-title: Autophagy: Definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury publication-title: J Cardiovasc Pharmacol Ther doi: 10.1177/1074248410370327 – volume: 6 start-page: 1031 year: 2013 end-page: 1038 ident: b18-mmr-17-03-4573 article-title: Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells publication-title: Oncol Lett doi: 10.3892/ol.2013.1498 – volume: 442 start-page: 289 year: 2008 end-page: 306 ident: b35-mmr-17-03-4573 article-title: Detection of autophagy in cell death publication-title: Methods Enzymol doi: 10.1016/S0076-6879(08)01415-8 – volume: 8 start-page: 741 year: 2007 end-page: 752 ident: b32-mmr-17-03-4573 article-title: Self-eating and self-killing: Crosstalk between autophagy and apoptosis publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2239 – volume: 290 start-page: 1717 year: 2000 end-page: 1721 ident: b8-mmr-17-03-4573 article-title: Autophagy as a regulated pathway of cellular degradation publication-title: Science doi: 10.1126/science.290.5497.1717 – volume: 35 start-page: pii: e00199 year: 2015 ident: b14-mmr-17-03-4573 article-title: MAPK/JNK signalling: A potential autophagy regulation pathway publication-title: Biosci Rep – volume: 34 start-page: 636 year: 2013 end-page: 643 ident: b13-mmr-17-03-4573 article-title: The protective roles of autophagy in ischemic preconditioning publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2013.18 – volume: 42 start-page: 850 year: 2005 end-page: 859 ident: b28-mmr-17-03-4573 article-title: JNK mediates hepatic ischemia reperfusion injury publication-title: J Hepatol doi: 10.1016/j.jhep.2005.01.030 – volume: 28 start-page: 525 year: 2011 end-page: 534 ident: b7-mmr-17-03-4573 article-title: Propofol post-conditioning protects against cardiomyocyte apoptosis in hypoxia/reoxygenation injury by suppressing nuclear factor-kappa B translocation via extracellular signal-regulated kinase mitogen-activated protein kinase pathway publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0b013e32834296d5 – volume: 40 start-page: 846 year: 2006 end-page: 852 ident: b33-mmr-17-03-4573 article-title: Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2006.03.428 – volume: 103 start-page: 239 year: 2000 end-page: 252 ident: b27-mmr-17-03-4573 article-title: Signal transduction by the JNK group of MAP kinases publication-title: Cell doi: 10.1016/S0092-8674(00)00116-1 – volume: 285 start-page: H579 year: 2003 end-page: H588 ident: b3-mmr-17-03-4573 article-title: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01064.2002 – volume: 445 start-page: 77 year: 2008 end-page: 88 ident: b15-mmr-17-03-4573 article-title: LC3 and autophagy publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-157-4_4 – volume: 35 start-page: 1427 year: 2015 end-page: 1434 ident: b17-mmr-17-03-4573 article-title: SP600125 reduces lipopolysaccharide-induced apoptosis and restores the early-stage differentiation of osteoblasts inhibited by LPS through the MAPK pathway in MC3T3-E1 cells publication-title: Int J Mol Med doi: 10.3892/ijmm.2015.2130 – volume: 44 start-page: 654 year: 2008 end-page: 661 ident: b25-mmr-17-03-4573 article-title: Recycle or die: The role of autophagy in cardioprotection publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2008.01.010 – volume: 4 start-page: 416 year: 2008 end-page: 421 ident: b24-mmr-17-03-4573 article-title: Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion publication-title: Autophagy doi: 10.4161/auto.5655 – volume: 1357 start-page: 142 year: 2010 end-page: 151 ident: b5-mmr-17-03-4573 article-title: Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway publication-title: Brain Res doi: 10.1016/j.brainres.2010.08.009 – volume: 10 start-page: 3639 year: 2004 end-page: 3649 ident: b6-mmr-17-03-4573 article-title: Propofol: Therapeutic indications and side-effects publication-title: Curr Pharm Des doi: 10.2174/1381612043382846 – volume: 4 start-page: 409 year: 2008 end-page: 415 ident: b26-mmr-17-03-4573 article-title: Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion publication-title: Autophagy doi: 10.4161/auto.5638 – volume: 88 start-page: 572 year: 1998 end-page: 578 ident: b1-mmr-17-03-4573 article-title: Myocardial infarction after noncardiac surgery publication-title: Anesthesiology doi: 10.1097/00000542-199803000-00005 – volume: 2014 start-page: 601250 year: 2014 ident: b22-mmr-17-03-4573 article-title: Propofol protects the immature rabbit heart against ischemia and reperfusion injury: Impact on functional recovery and histopathological changes publication-title: Biomed Res Int – volume: 2 start-page: 305 year: 2006 end-page: 306 ident: b11-mmr-17-03-4573 article-title: Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte? publication-title: Autophagy doi: 10.4161/auto.2946 – volume: 3 start-page: 1035 year: 2005 end-page: 1045 ident: b4-mmr-17-03-4573 article-title: Myocardial protection in reperfusion with postconditioning publication-title: Expert Rev Cardiovasc Ther doi: 10.1586/14779072.3.6.1035 – volume: 3 start-page: 365 year: 2010 end-page: 373 ident: b34-mmr-17-03-4573 article-title: Autophagy induced by ischemic preconditioning is essential for cardioprotection publication-title: J Cardiovasc Transl Res doi: 10.1007/s12265-010-9189-3 – volume: 121 start-page: 2685 year: 2008 end-page: 2695 ident: b16-mmr-17-03-4573 article-title: The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes publication-title: J Cell Sci doi: 10.1242/jcs.026005 – volume: 68 start-page: 259 year: 1998 end-page: 268 ident: b19-mmr-17-03-4573 article-title: Differentiation-dependent expression of cardiac delta-CaMKII isoforms publication-title: J Cell Biochem doi: 10.1002/(SICI)1097-4644(19980201)68:2<259::AID-JCB12>3.0.CO;2-A – volume: 26 start-page: 9220 year: 2006 end-page: 9231 ident: b30-mmr-17-03-4573 article-title: Autophagy is activated for cell survival after endoplasmic reticulum stress publication-title: Mol Cell Biol doi: 10.1128/MCB.01453-06 – volume: 5 start-page: 120 year: 2009 end-page: 121 ident: b12-mmr-17-03-4573 article-title: BAG-1 induces autophagy for cardiac cell survival publication-title: Autophagy doi: 10.4161/auto.5.1.7303 – volume: 6 start-page: 1221 year: 2004 end-page: 1228 ident: b31-mmr-17-03-4573 article-title: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes publication-title: Nat Cell Biol doi: 10.1038/ncb1192 – volume: 29 start-page: 2070 year: 2010 end-page: 2082 ident: b29-mmr-17-03-4573 article-title: Involvement of JNK in the regulation of autophagic cell death publication-title: Oncogene doi: 10.1038/onc.2009.487 – volume: 291 start-page: H1 year: 2006 end-page: 19H ident: b10-mmr-17-03-4573 article-title: The ubiquitin-proteasome system in cardiac physiology and pathology publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00062.2006 – volume: 26 start-page: 9220 year: 2006 ident: key20200713224356_b30-mmr-17-03-4573 article-title: Autophagy is activated for cell survival after endoplasmic reticulum stress publication-title: Mol Cell Biol doi: 10.1128/MCB.01453-06 – volume: 3 start-page: 365 year: 2010 ident: key20200713224356_b34-mmr-17-03-4573 article-title: Autophagy induced by ischemic preconditioning is essential for cardioprotection publication-title: J Cardiovasc Transl Res doi: 10.1007/s12265-010-9189-3 – volume: 29 start-page: 2070 year: 2010 ident: key20200713224356_b29-mmr-17-03-4573 article-title: Involvement of JNK in the regulation of autophagic cell death publication-title: Oncogene doi: 10.1038/onc.2009.487 – volume: 36 start-page: 2491 year: 2004 ident: key20200713224356_b21-mmr-17-03-4573 article-title: Methods for monitoring autophagy publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2004.02.005 – volume: 34 start-page: 636 year: 2013 ident: key20200713224356_b13-mmr-17-03-4573 article-title: The protective roles of autophagy in ischemic preconditioning publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2013.18 – volume: 6 start-page: 1221 year: 2004 ident: key20200713224356_b31-mmr-17-03-4573 article-title: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes publication-title: Nat Cell Biol doi: 10.1038/ncb1192 – volume: 8 start-page: 741 year: 2007 ident: key20200713224356_b32-mmr-17-03-4573 article-title: Self-eating and self-killing: Crosstalk between autophagy and apoptosis publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2239 – volume: 10 start-page: 3639 year: 2004 ident: key20200713224356_b6-mmr-17-03-4573 article-title: Propofol: Therapeutic indications and side-effects publication-title: Curr Pharm Des doi: 10.2174/1381612043382846 – volume: 5 start-page: 120 year: 2009 ident: key20200713224356_b12-mmr-17-03-4573 article-title: BAG-1 induces autophagy for cardiac cell survival publication-title: Autophagy doi: 10.4161/auto.5.1.7303 – volume: 35 start-page: pii: e00199 year: 2015 ident: key20200713224356_b14-mmr-17-03-4573 article-title: MAPK/JNK signalling: A potential autophagy regulation pathway publication-title: Biosci Rep doi: 10.1042/BSR20140141 – volume: 4 start-page: 416 year: 2008 ident: key20200713224356_b24-mmr-17-03-4573 article-title: Eat your heart out: Role of autophagy in myocardial ischemia/reperfusion publication-title: Autophagy doi: 10.4161/auto.5655 – volume: 6 start-page: 463 year: 2004 ident: key20200713224356_b9-mmr-17-03-4573 article-title: Development by self-digestion: Molecular mechanisms and biological functions of autophagy publication-title: Dev Cell doi: 10.1016/S1534-5807(04)00099-1 – volume: 40 start-page: 846 year: 2006 ident: key20200713224356_b33-mmr-17-03-4573 article-title: Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2006.03.428 – volume: 121 start-page: 2685 year: 2008 ident: key20200713224356_b16-mmr-17-03-4573 article-title: The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes publication-title: J Cell Sci doi: 10.1242/jcs.026005 – volume: 285 start-page: H579 year: 2003 ident: key20200713224356_b3-mmr-17-03-4573 article-title: Inhibition of myocardial injury by ischemic postconditioning during reperfusion: comparison with ischemic preconditioning publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01064.2002 – volume: 42 start-page: 850 year: 2005 ident: key20200713224356_b28-mmr-17-03-4573 article-title: JNK mediates hepatic ischemia reperfusion injury publication-title: J Hepatol doi: 10.1016/j.jhep.2005.01.030 – volume: 445 start-page: 77 year: 2008 ident: key20200713224356_b15-mmr-17-03-4573 article-title: LC3 and autophagy publication-title: Methods Mol Biol doi: 10.1007/978-1-59745-157-4_4 – volume: 1357 start-page: 142 year: 2010 ident: key20200713224356_b5-mmr-17-03-4573 article-title: Postconditioning with sevoflurane protects against focal cerebral ischemia and reperfusion injury via PI3K/Akt pathway publication-title: Brain Res doi: 10.1016/j.brainres.2010.08.009 – volume: 3 start-page: 1035 year: 2005 ident: key20200713224356_b4-mmr-17-03-4573 article-title: Myocardial protection in reperfusion with postconditioning publication-title: Expert Rev Cardiovasc Ther doi: 10.1586/14779072.3.6.1035 – volume: 2 start-page: 144 year: 1984 ident: key20200713224356_b20-mmr-17-03-4573 article-title: Lactate dehydrogenase and cell injury publication-title: Cell Biochem Funct doi: 10.1002/cbf.290020305 – volume: 291 start-page: H1 year: 2006 ident: key20200713224356_b10-mmr-17-03-4573 article-title: The ubiquitin-proteasome system in cardiac physiology and pathology publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00062.2006 – volume: 68 start-page: 259 year: 1998 ident: key20200713224356_b19-mmr-17-03-4573 article-title: Differentiation-dependent expression of cardiac delta-CaMKII isoforms publication-title: J Cell Biochem doi: 10.1002/(SICI)1097-4644(19980201)68:2<259::AID-JCB12>3.0.CO;2-A – volume: 74 start-page: 1124 year: 1986 ident: key20200713224356_b2-mmr-17-03-4573 article-title: Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium publication-title: Circulation doi: 10.1161/01.CIR.74.5.1124 – volume: 4 start-page: 409 year: 2008 ident: key20200713224356_b26-mmr-17-03-4573 article-title: Molecular mechanisms and physiological significance of autophagy during myocardial ischemia and reperfusion publication-title: Autophagy doi: 10.4161/auto.5638 – volume: 28 start-page: 525 year: 2011 ident: key20200713224356_b7-mmr-17-03-4573 article-title: Propofol post-conditioning protects against cardiomyocyte apoptosis in hypoxia/reoxygenation injury by suppressing nuclear factor-kappa B translocation via extracellular signal-regulated kinase mitogen-activated protein kinase pathway publication-title: Eur J Anaesthesiol doi: 10.1097/EJA.0b013e32834296d5 – volume: 290 start-page: 1717 year: 2000 ident: key20200713224356_b8-mmr-17-03-4573 article-title: Autophagy as a regulated pathway of cellular degradation publication-title: Science doi: 10.1126/science.290.5497.1717 – volume: 2 start-page: 305 year: 2006 ident: key20200713224356_b11-mmr-17-03-4573 article-title: Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte? publication-title: Autophagy doi: 10.4161/auto.2946 – volume: 35 start-page: 1427 year: 2015 ident: key20200713224356_b17-mmr-17-03-4573 article-title: SP600125 reduces lipopolysaccharide-induced apoptosis and restores the early-stage differentiation of osteoblasts inhibited by LPS through the MAPK pathway in MC3T3-E1 cells publication-title: Int J Mol Med doi: 10.3892/ijmm.2015.2130 – volume: 44 start-page: 654 year: 2008 ident: key20200713224356_b25-mmr-17-03-4573 article-title: Recycle or die: The role of autophagy in cardioprotection publication-title: J Mol Cell Cardiol doi: 10.1016/j.yjmcc.2008.01.010 – volume: 88 start-page: 572 year: 1998 ident: key20200713224356_b1-mmr-17-03-4573 article-title: Myocardial infarction after noncardiac surgery publication-title: Anesthesiology doi: 10.1097/00000542-199803000-00005 – volume: 6 start-page: 1031 year: 2013 ident: key20200713224356_b18-mmr-17-03-4573 article-title: Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells publication-title: Oncol Lett doi: 10.3892/ol.2013.1498 – volume: 15 start-page: 220 year: 2010 ident: key20200713224356_b23-mmr-17-03-4573 article-title: Autophagy: Definition, molecular machinery, and potential role in myocardial ischemia-reperfusion injury publication-title: J Cardiovasc Pharmacol Ther doi: 10.1177/1074248410370327 – volume: 442 start-page: 289 year: 2008 ident: key20200713224356_b35-mmr-17-03-4573 article-title: Detection of autophagy in cell death publication-title: Methods Enzymol doi: 10.1016/S0076-6879(08)01415-8 – volume: 2014 start-page: 601250 year: 2014 ident: key20200713224356_b22-mmr-17-03-4573 article-title: Propofol protects the immature rabbit heart against ischemia and reperfusion injury: Impact on functional recovery and histopathological changes publication-title: Biomed Res Int – volume: 103 start-page: 239 year: 2000 ident: key20200713224356_b27-mmr-17-03-4573 article-title: Signal transduction by the JNK group of MAP kinases publication-title: Cell doi: 10.1016/S0092-8674(00)00116-1 |
| SSID | ssj0065259 |
| Score | 2.2229187 |
| Snippet | Propofol postconditioning (P-PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion... Propofol postconditioning (P‑PostC) offers cardioprotection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion... Propofol postconditioning (P-PostC) offers cardio protection in mice, and the upregulation of autophagy protects cardiac cells against ischemia/reperfusion... |
| SourceID | proquest gale pubmed crossref spandidos |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 4573 |
| SubjectTerms | Adenine - analogs & derivatives Adenine - pharmacology Animals Anthracenes - pharmacology Apoptosis Autophagy Autophagy - drug effects Biotechnology c-Jun protein Cardiomyocytes cardioprotection Cell culture Cell Hypoxia Cell survival Dosage and administration Drug interactions Health aspects Heart Heart diseases Hypoxia Immunofluorescence Ischemia ischemic postconditioning JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors JNK Mitogen-Activated Protein Kinases - metabolism JNK protein Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Lactic acid MAP kinase MAP Kinase Signaling System - drug effects Microtubule-Associated Proteins - metabolism myocardial ischemia Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Observations Oxygen - pharmacology Phagocytosis Phosphorylation Phosphorylation - drug effects Propofol Propofol - pharmacology Protein kinases Proteins Rats Reperfusion Sequestosome-1 Protein - metabolism Stem cells Studies Transcription factors Transmission electron microscopy Western blotting |
| Title | Propofol postconditioning protects H9c2 cells from hypoxia/reoxygenation injury by inducing autophagy via the SAPK/JNK pathway |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/29328382 https://www.proquest.com/docview/1994733339 https://www.proquest.com/docview/1989608227 |
| Volume | 17 |
| WOSCitedRecordID | wos000424400000145&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1791-3004 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0065259 issn: 1791-2997 databaseCode: M7P dateStart: 20120101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1791-3004 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0065259 issn: 1791-2997 databaseCode: BENPR dateStart: 20120101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest_Health & Medical Collection customDbUrl: eissn: 1791-3004 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0065259 issn: 1791-2997 databaseCode: 7X7 dateStart: 20120101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZoC4IL70egrIyE4ELYTezEzgktqFVFpdWKh7S3yE8IapOl2S3Nhd_OTJINXSS4kIMVyU5i67PHM479fYQ8F3GivRAQm2SeQ5K6UAP0oWNMZM5IrZ1qxSbEbCYXi2zeL7jV_bbKjU1sDbWtDK6Rj5HDVjC4sjfL7yGqRuHf1V5CY4fsIUsCa7fuzTeWOE3iViwNGThDMLui49iEKToen54iGWgkX0se86056U_LfGlqug6DvLSFrepLc9Dhrf-t_W1ys_c-6bTrLnfIFVfeJdc6PcrmHvk5R80EX53QZVWvIFK2Rb9eS3s-h5oeZSamuNxfUzyaQr82y-qiQJ6p6qKB3tgiTYvyG4BFdQN3dm3wDWqNHAbqS0PPC0XB76Qfp_Pj8fvZMUVZ5B-quU8-Hx58encU9gINoeFJtgpFOtEi0irVGdgKG6UuM8YwJayHMMjKhDumHLicEy89U5lSkRVOeWdF5I0W7AHZLavSPSI0FpZxz41nNuHGJYorzmItrdeZdSIJyKsNRLnp2ctRROMkhygGEc0B0RwRzRHRgLwYii872o6_FXyJeOc4nOF9RvWnEqBWSIyVT5MYPTQxkQHZ3yoJw9BsZ2-Qz3szUOe_YQ_IsyEbn8StbaWr1lhGQhQJfpoIyMOupw1VBl8M3D8ZB4QOXW_IhHaE4GJMWMgTwR7_-_tPyA1sc7d7bp_srs7W7im5as5XRX02IjtiIdpUjsje24PZ_MOoHUq_AD4TJUE |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1db9MwFLXGAI0XvgeBAUbi44Wsre3UyQNCFTB1dFSV2KS-BX9C0ZaUpd2WF34Sv5F7mzSsSPC2B_pQVbLrxs3x9bmxfQ4hzySLtJcScpPEC3jrulDDrQ8d5zJxJtbaqYXZhBwO4_E4Ga2Rn8uzMLitchkTF4Ha5gafkbdQw1ZyeCVvpt9DdI3C1dWlhUYFi4ErTyFlK17vvoP7-5yxnff7b_th7SoQGhEls1B221p2tOrqBABuO12XGGO4ktYDd7dxJBxXDnhS28eeq0SpjpVOeWdlxxstObR7iVyGOC5xC5kcNwleN2ILczZU_AwhzMtK0xMoAWsdHaH4aCfejgUTK3PgnzPBualwA4JKZic2L87NeTs3_rd_6ya5XrNr2quGwy2y5rLb5Grlt1neIT9G6Anh80M6zYuZyXG5vnoeTWu9ioL2E8MoLmcUFI_e0K_lND-boI5WflbCaFsgmU6ybwBGqkv4ZOcGW1Bz1GhQX0p6MlEUeDX91BsNWh-GA4q2z6eqvEsOLqTzm2Q9yzN3n1AmLRdeGM9tJIyLlFCCMx1brxPrZBSQV0tIpKZWZ0eTkMMUsjREUAoIShFBKSIoIC-a6tNKluRvFV8ivlIMV9CeUfWpC7gqFP5KexFDBirbcUC2VmpCmDGrxUukpXWYK9LfMAvI06YYv4lb9zKXz7FODFky8FAZkHsVsptLBq4J9DZmAaEN1JtC6EcIFKrNQxFJ_uDfv_-EbPT3P-6le7vDwUNyDftf7RTcIuuz47l7RK6Yk9mkOH68GLKUfL5o1P8CRXuByg |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1bb9MwGLXGuL5wvwQGGInLC6Gt7cTJA0IVo9ooVJUAaW_BVyjakrK02_LCD-PX8X25lA0J3vZAH6pKdt24Of6-49g-h5DHkkXaSwlzk9QLeItdqOHWh45zmTqTaO1UbTYhJ5NkZyedrpGf3VkY3FbZxcQ6UNvC4DPyHmrYSg6vtOfbbRHTzdGr-fcQHaRwpbWz02ggMnbVIUzfypfbm3CvnzA2evPx9VbYOgyERkTpIpRxX8uBVrFOAex2ELvUGMOVtB54vE0i4bhywJn6PvFcpUoNrHTKOysH3mjJod0z5KwUcR0U3stplwXiiNVGbaj-GULIl42-J9AD1tvbQyHSQfIiEUycyId_ZoVjafEiBJjczmxRHst_oyv_8z93lVxuWTcdNsPkGllz-XVyvvHhrG6QH1P0ivDFLp0X5cIUuIzfPKemrY5FSbdSwyguc5QUj-TQr9W8OJqhvlZxVMEorBFOZ_k3ACnVFXyyS4MtqCVqN6gvFT2YKQp8m34YTse9t5MxRTvoQ1XdJJ9OpfO3yHpe5O4OoUxaLrwwnttIGBcpoQRnOrFep9bJKCDPO3hkplVtR_OQ3Qxmb4imDNCUIZoyRFNAnq6qzxu5kr9VfIZYyzCMQXtGtacx4KpQECwbRgyZqewnAdk4URPCjzlZ3KEua8Nfmf2GXEAerYrxm7ilL3fFEuskMHsGfioDcrtB-eqSgYMC7U1YQOgK9qtC6EcI1KrPQxFJfvffv_-QXACwZ--2J-N75BJ2v9lAuEHWF_tLd5-cMweLWbn_oB69lHw-bdD_Ara5ipk |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Propofol+postconditioning+protects+H9c2+cells+from+hypoxia%2Freoxygenation+injury+by+inducing+autophagy+via+the+SAPK%2FJNK+pathway&rft.jtitle=Molecular+medicine+reports&rft.au=Li%2C+Hao&rft.au=Zhang%2C+Xuan&rft.au=Tan%2C+Jian&rft.au=Sun%2C+Li&rft.date=2018-03-01&rft.pub=D.A.+Spandidos&rft.issn=1791-2997&rft.eissn=1791-3004&rft.volume=17&rft.issue=3&rft.spage=4573&rft.epage=4580&rft_id=info:doi/10.3892%2Fmmr.2018.8424&rft.externalDBID=n%2Fa&rft.externalDocID=mmr-17-03-4573 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1791-2997&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1791-2997&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1791-2997&client=summon |