Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1

Despite the importance of a cell's ability to sense and respond to mechanical force, the molecular mechanisms by which physical cues are converted to cell-instructive chemical information to influence cell behaviors remain to be elucidated. Exposure of cultured fibroblasts to uniaxial cyclic st...

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Bibliographic Details
Published in:	Molecular biology of the cell Vol. 28; no. 20; p. 2661
Main Authors:	Hoffman, Laura, Jensen, Christopher C, Yoshigi, Masaaki, Beckerle, Mary
Format:	Journal Article
Language:	English
Published:	United States 01.10.2017
Subjects:	Actin Cytoskeleton - metabolism Actins - metabolism Animals Cell Movement - physiology Cells, Cultured Cytoskeletal Proteins - metabolism Cytoskeleton - metabolism Fibroblasts - metabolism Focal Adhesions - metabolism Heat-Shock Proteins - metabolism MAP Kinase Signaling System Mechanical Phenomena Mice Neoplasm Proteins - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Signal Transduction Stress Fibers - metabolism Stress, Mechanical Zyxin - metabolism
ISSN:	1939-4586, 1939-4586
Online Access:	Get more information
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