Lactobacillus reuteri DSM 17938 Probiotics May Increase CC-Chemokine Receptor 7 Expression in Infants Treated With for Colic

Studies have shown that ri probiotics can affect cells that play a key role in the immune system. This Italian study investigated how DSM 17938 influenced CC-chemokine receptor 7 (CCR7) and interleukin 10 (IL-10) in breastfed colicky infants. Our University hospital in Turin recruited 50 healthy out...

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Vydané v:Frontiers in pediatrics Ročník 7; s. 292
Hlavní autori: Savino, Francesco, Galliano, Ilaria, Savino, Andrea, Daprà, Valentina, Montanari, Paola, Calvi, Cristina, Bergallo, Massimiliano
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 16.07.2019
Predmet:
breastfeeding
CC-chemokine receptor 7
colicky infants
Interleukin 10
Lactobacillus reuteri
Pediatrics
Lactobacillus reuteri
breastfeeding
colicky infants
Interleukin 10
CC-chemokine receptor 7
ISSN:2296-2360, 2296-2360
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Shrnutí:Studies have shown that ri probiotics can affect cells that play a key role in the immune system. This Italian study investigated how DSM 17938 influenced CC-chemokine receptor 7 (CCR7) and interleukin 10 (IL-10) in breastfed colicky infants. Our University hospital in Turin recruited 50 healthy outpatients, at a median age of approximately 1 month, from September 2017 to August 2018. They were randomized to daily DSM17938 (1 × 10 cfu) or a placebo for 28 days from recruitment. We collected peripheral blood and evaluated the expression of CCR7 messenger ribonucleic acid using the real-time TaqMan reverse transcription polymerase chain reaction method at baseline and after the study period. We found increased expression of CC-chemokine receptor 7 in infants treated with the probiotic, but not the controls ( < 0.0026). No differences were observed for interleukin 10 after the study period in either group. At baseline, daily crying time was comparable in the probiotic and control groups: 341 (25) vs. 337 (29) min., respectively ( = 0.450). After 28 days, daily mean crying time decrease statistically in the probiotic group: 78 (23) vs. 232 (31), respectively ( < 0.001). The increase in CC-chemokine receptor 7 might have been a response to probiotic treatment. As a relatively small sample was used to conduct this study, our research needs to be replicated in different settings, and over time, to produce comparable findings.
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This article was submitted to Pediatric Gastroenterology, Hepatology and Nutrition, a section of the journal Frontiers in Pediatrics
Reviewed by: Duška Tješić-Drinković, University of Zagreb, Croatia; Rajni Ahlawat, Marshfield Clinic, United States
Edited by: Jorge Amil Dias, Centro Hospitalar de São João, Portugal
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2019.00292