Cancer-ID: Toward Identification of Cancer by Tumor-Derived Extracellular Vesicles in Blood

Extracellular vesicles (EVs) have great potential as biomarkers since their composition and concentration in biofluids are disease state dependent and their cargo can contain disease-related information. Large tumor-derived EVs (tdEVs, >1 μm) in blood from cancer patients are associated with poor...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Frontiers in oncology Ročník 10; s. 608
Hlavní autoři: Rikkert, L. G., Beekman, P., Caro, J., Coumans, F. A. W., Enciso-Martinez, A., Jenster, G., Le Gac, S., Lee, W., van Leeuwen, T. G., Loozen, G. B., Nanou, A., Nieuwland, R., Offerhaus, H. L., Otto, C., Pegtel, D. M., Piontek, M. C., van der Pol, E., de Rond, L., Roos, W. H., Schasfoort, R. B. M., Wauben, M. H. M., Zuilhof, H., Terstappen, L. W. M. M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 04.06.2020
Témata:
atomic force microscopy
electrochemistry
electron microscopy
extracellular vesicles
flow cytometry
fluorescence microscopy
Oncology
extracellular vesicles
electrochemistry
surface plasmon resonance imaging
electron microscopy
flow cytometry
Raman spectrum analysis
atomic force microscopy
fluorescence microscopy
ISSN:2234-943X, 2234-943X
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Extracellular vesicles (EVs) have great potential as biomarkers since their composition and concentration in biofluids are disease state dependent and their cargo can contain disease-related information. Large tumor-derived EVs (tdEVs, >1 μm) in blood from cancer patients are associated with poor outcome, and changes in their number can be used to monitor therapy effectiveness. Whereas, small tumor-derived EVs (<1 μm) are likely to outnumber their larger counterparts, thereby offering better statistical significance, identification and quantification of small tdEVs are more challenging. In the blood of cancer patients, a subpopulation of EVs originate from tumor cells, but these EVs are outnumbered by non-EV particles and EVs from other origin. In the Dutch NWO Perspectief Cancer-ID program, we developed and evaluated detection and characterization techniques to distinguish EVs from non-EV particles and other EVs. Despite low signal amplitudes, we identified characteristics of these small tdEVs that may enable the enumeration of small tdEVs and extract relevant information. The insights obtained from Cancer-ID can help to explore the full potential of tdEVs in the clinic.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Reviewed by: Masaki Terabe, National Cancer Institute, National Institutes of Health (NIH), United States; Victor C. Kok, Asia University, Taiwan
Edited by: Elisabetta Rossi, University of Padova, Italy
This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.00608