Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxi...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Frontiers in oncology Ročník 9; s. 1146
Hlavní autoři:	Masucci, Maria Teresa, Minopoli, Michele, Carriero, Maria Vincenza
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Switzerland Frontiers Media S.A 15.11.2019
Témata:	angiogenesis neutrophil-to-lymphocyte ratio Oncology tumor associated neutrophils tumor microenvironment tumorigenesis tumor associated neutrophils neutrophil-to-lymphocyte ratio tumor microenvironment tumorigenesis angiogenesis
ISSN:	2234-943X, 2234-943X
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxicity. N2 TANs stimulate immunosuppression, tumor growth, angiogenesis and metastasis by DNA instability, or by cytokines and chemokines release. In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers. Owing to the pivotal role of TANs in stimulating tumor progression, therapeutic strategies to target TANs have been suggested, and two major approaches have been proposed: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis, thereby blocking TANs or (b) targeting substances produced by polymorpho-nuclear cells that promote tumor growth. Many studies have been accomplished either and in animal models, whereas clinical studies are restrained, presently, due to the risk of inducing immunosuppression. In this review, we deeply discuss the anti-tumorigenic or pro-tumorigenic activity of TANs. In particular, TANs relevance in tumor prognosis and therapeutic strategies are widely described. On-going clinical trials, aimed to inhibit neutrophil recruitment into the tumor are also accurately debated.
AbstractList	Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxicity. N2 TANs stimulate immunosuppression, tumor growth, angiogenesis and metastasis by DNA instability, or by cytokines and chemokines release. In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers. Owing to the pivotal role of TANs in stimulating tumor progression, therapeutic strategies to target TANs have been suggested, and two major approaches have been proposed: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis, thereby blocking TANs or (b) targeting substances produced by polymorpho-nuclear cells that promote tumor growth. Many studies have been accomplished either in vitro and in animal models, whereas clinical studies are restrained, presently, due to the risk of inducing immunosuppression. In this review, we deeply discuss the anti-tumorigenic or pro-tumorigenic activity of TANs. In particular, TANs relevance in tumor prognosis and in vitro therapeutic strategies are widely described. On-going clinical trials, aimed to inhibit neutrophil recruitment into the tumor are also accurately debated. Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxicity. N2 TANs stimulate immunosuppression, tumor growth, angiogenesis and metastasis by DNA instability, or by cytokines and chemokines release. In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers. Owing to the pivotal role of TANs in stimulating tumor progression, therapeutic strategies to target TANs have been suggested, and two major approaches have been proposed: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis, thereby blocking TANs or (b) targeting substances produced by polymorpho-nuclear cells that promote tumor growth. Many studies have been accomplished either and in animal models, whereas clinical studies are restrained, presently, due to the risk of inducing immunosuppression. In this review, we deeply discuss the anti-tumorigenic or pro-tumorigenic activity of TANs. In particular, TANs relevance in tumor prognosis and therapeutic strategies are widely described. On-going clinical trials, aimed to inhibit neutrophil recruitment into the tumor are also accurately debated. Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxicity. N2 TANs stimulate immunosuppression, tumor growth, angiogenesis and metastasis by DNA instability, or by cytokines and chemokines release. In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers. Owing to the pivotal role of TANs in stimulating tumor progression, therapeutic strategies to target TANs have been suggested, and two major approaches have been proposed: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis, thereby blocking TANs or (b) targeting substances produced by polymorpho-nuclear cells that promote tumor growth. Many studies have been accomplished either in vitro and in animal models, whereas clinical studies are restrained, presently, due to the risk of inducing immunosuppression. In this review, we deeply discuss the anti-tumorigenic or pro-tumorigenic activity of TANs. In particular, TANs relevance in tumor prognosis and in vitro therapeutic strategies are widely described. On-going clinical trials, aimed to inhibit neutrophil recruitment into the tumor are also accurately debated.Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation and cytokine status and effects on tumor cell growing in N1 and N2 TANs. N1 TANs exert an antitumor activity, by direct or indirect cytotoxicity. N2 TANs stimulate immunosuppression, tumor growth, angiogenesis and metastasis by DNA instability, or by cytokines and chemokines release. In tumor patients, either a high number of TANs and Neutrophil-to-Lymphocyte Ratio (NLR) do correlate with poor prognosis, and, so far, TAN counts and NLR can be regarded as biomarkers. Owing to the pivotal role of TANs in stimulating tumor progression, therapeutic strategies to target TANs have been suggested, and two major approaches have been proposed: (a) targeting the CXCL-8/CXCR-1/CXCR-2 axis, thereby blocking TANs or (b) targeting substances produced by polymorpho-nuclear cells that promote tumor growth. Many studies have been accomplished either in vitro and in animal models, whereas clinical studies are restrained, presently, due to the risk of inducing immunosuppression. In this review, we deeply discuss the anti-tumorigenic or pro-tumorigenic activity of TANs. In particular, TANs relevance in tumor prognosis and in vitro therapeutic strategies are widely described. On-going clinical trials, aimed to inhibit neutrophil recruitment into the tumor are also accurately debated.
Author	Masucci, Maria Teresa Carriero, Maria Vincenza Minopoli, Michele
AuthorAffiliation	Tumor Progression Unit, Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione “G. Pascale” IRCCS , Naples , Italy
AuthorAffiliation_xml	– name: Tumor Progression Unit, Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione “G. Pascale” IRCCS , Naples , Italy
Author_xml	– sequence: 1 givenname: Maria Teresa surname: Masucci fullname: Masucci, Maria Teresa – sequence: 2 givenname: Michele surname: Minopoli fullname: Minopoli, Michele – sequence: 3 givenname: Maria Vincenza surname: Carriero fullname: Carriero, Maria Vincenza
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31799175$$D View this record in MEDLINE/PubMed
BookMark	eNp1Us1rFDEUD1Kxde3Zm8zRg7tNJpPM5CKUYrVQP5AVPAjhbfJmN2U2WZOM0P--md1aWsEQyHvJ7yPwfi_JkQ8eCXnN6ILzTp31wZtFTZlaUMYa-Yyc1DVv5qrhP48e1cfkNKUbWpYUlFH-ghxz1irFWnFCfi3HbYjVeUrBOMhoqy845hh2GzekRbXcoIvV9zBg5Xy1x7o1ekwuvas-Y4ZU9lR_i2HtQykr8HaiRdjdviLPexgSnt6fM_Lj8sPy4tP8-uvHq4vz67lphMpzgUZ2LbYM6pb3VLVgBV_JnnPT1Ih9o6SCVqqW9mBX1tgOZCcKxKgVBUX5jFwddG2AG72LbgvxVgdwen8R4lpDzM4MqGXX1YICWi77ppOso5bzyVQaYH1pZuT9QWs3rrZoDfocYXgi-vTFu41ehz9FuW3KFIrA23uBGH6PmLLeumRwGMBjGJOuec2kFHWxnZE3j70eTP6OpwDODgATQ0oR-wcIo3rKgJ4yoKcM6H0GCkP8wzAuQ3Zh-qwb_su7A3Hht2U
CitedBy_id	crossref_primary_10_1016_j_bjoms_2023_03_012 crossref_primary_10_1002_iid3_379 crossref_primary_10_1039_D4NR01740D crossref_primary_10_1097_MD_0000000000043024 crossref_primary_10_1186_s12964_023_01424_6 crossref_primary_10_1016_j_smim_2025_101931 crossref_primary_10_3390_cancers13112771 crossref_primary_10_3390_jcm10225273 crossref_primary_10_3389_fimmu_2024_1506236 crossref_primary_10_1038_s41392_023_01528_y crossref_primary_10_1016_j_acuro_2022_12_006 crossref_primary_10_1158_1078_0432_CCR_18_0900 crossref_primary_10_1097_CM9_0000000000002919 crossref_primary_10_1186_s12964_023_01337_4 crossref_primary_10_1007_s00270_022_03288_8 crossref_primary_10_1016_j_canlet_2025_217865 crossref_primary_10_3390_cells10030627 crossref_primary_10_1002_cam4_4295 crossref_primary_10_1002_cam4_70960 crossref_primary_10_1002_cyto_a_24788 crossref_primary_10_1186_s12894_020_00665_8 crossref_primary_10_3390_cancers14071681 crossref_primary_10_3390_cells14060403 crossref_primary_10_1016_j_ejmech_2021_113812 crossref_primary_10_1002_adhm_202302714 crossref_primary_10_2147_IJGM_S312277 crossref_primary_10_1016_j_biopha_2024_117474 crossref_primary_10_3389_fcell_2023_1089068 crossref_primary_10_1186_s13148_021_01196_1 crossref_primary_10_3390_metabo10100384 crossref_primary_10_1155_2022_9443407 crossref_primary_10_3389_fimmu_2025_1530053 crossref_primary_10_3389_fimmu_2022_894021 crossref_primary_10_1002_1878_0261_12773 crossref_primary_10_1016_j_cellsig_2025_111822 crossref_primary_10_3390_biom13121803 crossref_primary_10_3390_genes12070975 crossref_primary_10_1038_s41417_021_00303_x crossref_primary_10_1177_15330338211045820 crossref_primary_10_1158_0008_5472_CAN_22_0968 crossref_primary_10_1101_gad_348226_120 crossref_primary_10_3389_fgene_2025_1539745 crossref_primary_10_1038_s41420_022_01087_1 crossref_primary_10_3389_fimmu_2023_1297493 crossref_primary_10_3390_cancers16162863 crossref_primary_10_3390_jcm12123888 crossref_primary_10_1080_00365521_2022_2088247 crossref_primary_10_1016_j_tranon_2024_102224 crossref_primary_10_1186_s12885_024_13159_9 crossref_primary_10_1016_j_celrep_2023_112508 crossref_primary_10_1016_j_jaad_2023_03_058 crossref_primary_10_1007_s11596_024_2950_7 crossref_primary_10_3390_cancers14092178 crossref_primary_10_3390_cancers13225778 crossref_primary_10_1186_s12943_023_01885_w crossref_primary_10_3389_fimmu_2025_1528084 crossref_primary_10_3390_cancers12051202 crossref_primary_10_1002_cam4_70899 crossref_primary_10_1242_jcs_247783 crossref_primary_10_1016_j_otorri_2023_07_005 crossref_primary_10_3390_ijms252111466 crossref_primary_10_3390_cells10113093 crossref_primary_10_3892_ol_2025_14977 crossref_primary_10_3389_fonc_2020_570113 crossref_primary_10_3390_life12020323 crossref_primary_10_1016_j_clim_2022_109216 crossref_primary_10_1186_s12885_023_11406_z crossref_primary_10_1007_s10555_022_10024_8 crossref_primary_10_1016_j_semcancer_2021_12_011 crossref_primary_10_3390_ijms23010124 crossref_primary_10_3390_ijms232012578 crossref_primary_10_1016_j_transproceed_2024_12_020 crossref_primary_10_15212_AMM_2023_0005 crossref_primary_10_3389_fonc_2023_1155511 crossref_primary_10_1016_j_chom_2021_08_013 crossref_primary_10_1111_prd_12490 crossref_primary_10_3389_fonc_2021_635324 crossref_primary_10_3390_ijms241713269 crossref_primary_10_1016_j_pharmthera_2022_108274 crossref_primary_10_1186_s10020_022_00435_2 crossref_primary_10_1007_s00774_022_01396_6 crossref_primary_10_1016_j_microb_2025_100236 crossref_primary_10_1155_2022_4889616 crossref_primary_10_1016_j_molimm_2025_04_010 crossref_primary_10_3389_fgene_2022_972352 crossref_primary_10_1002_ctm2_1599 crossref_primary_10_3390_cancers13112832 crossref_primary_10_3390_cells12010121 crossref_primary_10_1016_j_cyto_2022_155917 crossref_primary_10_1038_s41392_022_00899_y crossref_primary_10_1007_s12288_024_01839_2 crossref_primary_10_1080_07853890_2023_2279754 crossref_primary_10_1016_j_cyto_2020_155311 crossref_primary_10_1016_j_ijrobp_2023_09_027 crossref_primary_10_32074_1591_951X_1092 crossref_primary_10_3389_fimmu_2021_785222 crossref_primary_10_1007_s12032_025_02831_0 crossref_primary_10_1038_s41392_022_01102_y crossref_primary_10_1515_biol_2022_0687 crossref_primary_10_1007_s10555_021_09970_6 crossref_primary_10_1016_j_cell_2023_03_007 crossref_primary_10_1038_s41389_020_00249_z crossref_primary_10_3389_fimmu_2020_01749 crossref_primary_10_3390_cancers14205157 crossref_primary_10_1038_s41392_023_01462_z crossref_primary_10_3390_cancers12113385 crossref_primary_10_3390_cells11050909 crossref_primary_10_1016_j_lfs_2021_119952 crossref_primary_10_31083_j_fbl2910345 crossref_primary_10_3390_cancers14040985 crossref_primary_10_3389_fonc_2023_1151373 crossref_primary_10_1002_adbi_202400735 crossref_primary_10_1002_cac2_12388 crossref_primary_10_3390_cancers16142507 crossref_primary_10_3389_fonc_2022_958720 crossref_primary_10_3390_cancers14010204 crossref_primary_10_3390_cells12151981 crossref_primary_10_1038_s41598_022_07726_y crossref_primary_10_1002_mef2_23 crossref_primary_10_1016_j_critrevonc_2024_104311 crossref_primary_10_3389_fonc_2020_554331 crossref_primary_10_1016_j_imlet_2021_11_002 crossref_primary_10_3390_cancers14071710 crossref_primary_10_29252_ibj_25_1_1 crossref_primary_10_3389_fimmu_2024_1393173 crossref_primary_10_1002_JLB_3RU0222_087RRR crossref_primary_10_1002_pros_24597 crossref_primary_10_3390_cells13121057 crossref_primary_10_1158_0008_5472_CAN_20_2870 crossref_primary_10_1039_D4NR05294C crossref_primary_10_3390_ijms21124523 crossref_primary_10_1186_s12989_024_00583_9 crossref_primary_10_2147_CMAR_S500215 crossref_primary_10_3390_diagnostics14030328 crossref_primary_10_1016_j_jtho_2025_02_001 crossref_primary_10_1042_BST20221175 crossref_primary_10_3389_fimmu_2025_1623436 crossref_primary_10_3390_cancers13225625 crossref_primary_10_3390_cancers13225621 crossref_primary_10_1016_j_lfs_2023_122021 crossref_primary_10_1038_s41598_021_91947_0 crossref_primary_10_1007_s11605_021_04944_z crossref_primary_10_3390_cancers15041282 crossref_primary_10_1016_j_envres_2023_116432 crossref_primary_10_22270_ijmspr_v11i2_142 crossref_primary_10_1007_s11427_024_2831_x crossref_primary_10_3390_ijms26072923 crossref_primary_10_22270_ijmspr_v11i2_141 crossref_primary_10_3390_cancers15245790 crossref_primary_10_1038_s41598_024_81237_w crossref_primary_10_1126_scitranslmed_abj5070 crossref_primary_10_3390_v15010218 crossref_primary_10_3390_ijms24043065 crossref_primary_10_3389_fonc_2023_1116016 crossref_primary_10_1016_j_critrevonc_2025_104702 crossref_primary_10_1016_j_cej_2024_153436 crossref_primary_10_1093_bbb_zbaa057 crossref_primary_10_3389_fimmu_2025_1543403 crossref_primary_10_1002_med_21727 crossref_primary_10_1016_j_molimm_2024_11_009 crossref_primary_10_1186_s12943_023_01843_6 crossref_primary_10_1186_s13045_024_01634_6 crossref_primary_10_1055_s_0044_1789207 crossref_primary_10_3390_ijms232012068 crossref_primary_10_1177_10732748221148912 crossref_primary_10_1097_JS9_0000000000002543 crossref_primary_10_1038_s41598_024_70855_z crossref_primary_10_25259_SNI_849_2023 crossref_primary_10_3390_cells11071188 crossref_primary_10_1016_j_clinre_2022_101955 crossref_primary_10_1038_s41467_023_38624_0 crossref_primary_10_3390_cancers13071714 crossref_primary_10_3390_cells13231937 crossref_primary_10_1016_j_advms_2022_09_001 crossref_primary_10_1016_j_phrs_2025_107811 crossref_primary_10_3390_cancers16091626 crossref_primary_10_1111_ced_14988 crossref_primary_10_3389_fonc_2022_897968 crossref_primary_10_1007_s12032_023_02010_z crossref_primary_10_3389_fimmu_2021_832886 crossref_primary_10_1097_CM9_0000000000002846 crossref_primary_10_1186_s12935_022_02727_3 crossref_primary_10_1371_journal_pone_0237947 crossref_primary_10_1016_j_addr_2021_05_001 crossref_primary_10_3389_fonc_2023_1117648 crossref_primary_10_3390_cells12192404 crossref_primary_10_1016_j_otoeng_2023_07_003 crossref_primary_10_3390_jpm11030233 crossref_primary_10_3390_vetsci10080495 crossref_primary_10_1016_j_isci_2024_110854 crossref_primary_10_3389_fcell_2024_1302490 crossref_primary_10_1016_j_fsi_2022_09_002 crossref_primary_10_1038_s41598_025_92417_7 crossref_primary_10_12968_hmed_2024_0270 crossref_primary_10_1371_journal_pcbi_1008257 crossref_primary_10_1111_imr_13107 crossref_primary_10_2147_JIR_S284941 crossref_primary_10_2340_1651_226X_2025_44327 crossref_primary_10_3390_cancers14041092 crossref_primary_10_1038_s41419_023_06119_x crossref_primary_10_3389_fmed_2023_1174764 crossref_primary_10_3390_vaccines9101178 crossref_primary_10_1016_j_isci_2024_110632 crossref_primary_10_3389_fimmu_2025_1593156 crossref_primary_10_3390_vaccines9101184 crossref_primary_10_1016_j_addr_2021_114003 crossref_primary_10_1155_2023_2759679 crossref_primary_10_1186_s12957_022_02640_z crossref_primary_10_1186_s13046_023_02886_9 crossref_primary_10_2217_fon_2021_1304 crossref_primary_10_1016_j_bbrep_2025_102149 crossref_primary_10_3390_biom15081149 crossref_primary_10_3390_ijms21217820 crossref_primary_10_3389_fimmu_2024_1498391 crossref_primary_10_1016_j_rvsc_2023_105024 crossref_primary_10_15252_embj_2021108647 crossref_primary_10_3389_fmed_2024_1481609 crossref_primary_10_2217_lmt_2020_0014 crossref_primary_10_1007_s12017_025_08830_8 crossref_primary_10_1016_j_acuroe_2023_01_001 crossref_primary_10_3390_cancers14194965 crossref_primary_10_3390_biomedicines13010095 crossref_primary_10_1186_s13045_021_01134_x crossref_primary_10_1016_j_bbamcr_2023_119493 crossref_primary_10_1055_s_0040_1721799 crossref_primary_10_3389_fimmu_2025_1478092 crossref_primary_10_3892_etm_2024_12410 crossref_primary_10_1016_j_biopha_2021_111790 crossref_primary_10_1007_s10585_022_10170_x crossref_primary_10_3389_fmolb_2021_762729 crossref_primary_10_1016_j_jare_2024_07_033 crossref_primary_10_3390_cancers14143366 crossref_primary_10_1002_jbio_202200079 crossref_primary_10_1039_D4RA05732E crossref_primary_10_3390_brainsci14070687 crossref_primary_10_3389_fonc_2022_1010976 crossref_primary_10_1007_s12032_021_01602_x crossref_primary_10_1186_s42269_023_01106_w crossref_primary_10_1002_advs_202409260 crossref_primary_10_3389_fimmu_2022_850093 crossref_primary_10_1007_s00595_022_02637_x crossref_primary_10_3389_fnut_2025_1611829 crossref_primary_10_1016_j_livres_2023_01_001 crossref_primary_10_3389_fonc_2021_596798 crossref_primary_10_1016_j_cpt_2024_01_001 crossref_primary_10_1007_s11912_020_00938_3 crossref_primary_10_3390_biom11060901 crossref_primary_10_1038_s44321_025_00261_z crossref_primary_10_3389_fonc_2021_649004 crossref_primary_10_3390_ijms24020896 crossref_primary_10_3390_biomedicines10123035 crossref_primary_10_3390_biomedicines13061348 crossref_primary_10_1002_2211_5463_70099 crossref_primary_10_1155_2021_5598627 crossref_primary_10_1186_s12964_022_00951_y crossref_primary_10_1016_j_biopha_2022_112949 crossref_primary_10_3389_fimmu_2024_1331641 crossref_primary_10_1007_s00432_021_03814_0 crossref_primary_10_1177_17246008211023515 crossref_primary_10_2147_IJGM_S340057 crossref_primary_10_1111_jop_13285 crossref_primary_10_1002_jev2_12480 crossref_primary_10_3892_ol_2024_14322 crossref_primary_10_1097_CMR_0000000000000938 crossref_primary_10_3390_cancers14246151 crossref_primary_10_3389_fonc_2021_684478 crossref_primary_10_3389_fimmu_2023_1259797 crossref_primary_10_1136_jitc_2022_004643 crossref_primary_10_1158_1078_0432_CCR_23_1421 crossref_primary_10_1097_MS9_0000000000003269 crossref_primary_10_1177_00368504241304195 crossref_primary_10_1186_s13058_021_01388_w crossref_primary_10_1007_s00262_025_04049_5 crossref_primary_10_3390_cancers15020376 crossref_primary_10_1097_CM9_0000000000002573 crossref_primary_10_1186_s12885_021_07789_6 crossref_primary_10_1016_j_jconrel_2023_07_039 crossref_primary_10_1186_s12989_024_00611_8 crossref_primary_10_3389_fphar_2021_676399 crossref_primary_10_1002_wnan_1990 crossref_primary_10_3390_cancers14194755 crossref_primary_10_3389_fonc_2023_1130911 crossref_primary_10_1097_MEG_0000000000002528 crossref_primary_10_2147_IJN_S321416 crossref_primary_10_3389_fimmu_2020_553967 crossref_primary_10_3390_cancers13174495 crossref_primary_10_3389_fimmu_2023_1234142 crossref_primary_10_1093_oncolo_oyae212 crossref_primary_10_15252_embr_202153608 crossref_primary_10_3390_biology12060862 crossref_primary_10_1002_advs_202400370 crossref_primary_10_1186_s12957_023_03077_8 crossref_primary_10_1016_j_bioorg_2023_106608 crossref_primary_10_3390_cancers14041013 crossref_primary_10_3390_biomedicines11020533 crossref_primary_10_1016_j_imbio_2022_152247 crossref_primary_10_3390_biomedicines12010024 crossref_primary_10_1186_s12951_022_01346_4 crossref_primary_10_1016_j_bbrc_2022_08_062 crossref_primary_10_2147_TCRM_S532863 crossref_primary_10_1007_s12013_023_01192_7 crossref_primary_10_1155_2022_6837872 crossref_primary_10_3389_fimmu_2025_1568825 crossref_primary_10_1002_cti2_1397 crossref_primary_10_1021_acsami_4c05691 crossref_primary_10_3390_life13020333 crossref_primary_10_1111_imr_13176 crossref_primary_10_3390_biomedicines10071516 crossref_primary_10_3389_fimmu_2021_755856 crossref_primary_10_3390_ijms26062795 crossref_primary_10_1142_S0192415X22500604 crossref_primary_10_3389_fcell_2022_803947 crossref_primary_10_3390_genes13101897 crossref_primary_10_1016_j_bbadis_2025_167821 crossref_primary_10_3389_fonc_2025_1582788 crossref_primary_10_1002_btm2_10704 crossref_primary_10_1016_j_omto_2022_04_005 crossref_primary_10_3389_fimmu_2023_1177403 crossref_primary_10_3390_ijms22136744 crossref_primary_10_3390_vaccines11061028 crossref_primary_10_3892_mco_2024_2783 crossref_primary_10_1007_s10120_021_01197_2 crossref_primary_10_1186_s12974_024_03222_4 crossref_primary_10_4049_jimmunol_2300728 crossref_primary_10_1063_5_0160924 crossref_primary_10_3390_jcm11175096 crossref_primary_10_1016_j_bbcan_2020_188486 crossref_primary_10_3389_fimmu_2023_1169670 crossref_primary_10_3389_fimmu_2022_951406 crossref_primary_10_3390_biomedicines10030708 crossref_primary_10_3390_molecules28114413 crossref_primary_10_3390_pharmaceutics14081541 crossref_primary_10_1002_adtp_202400438 crossref_primary_10_3389_fimmu_2025_1590781 crossref_primary_10_3390_cells12060846 crossref_primary_10_3389_fonc_2023_1166860 crossref_primary_10_3390_biom12020291 crossref_primary_10_1016_j_canlet_2025_217466 crossref_primary_10_3389_fgene_2022_1029576 crossref_primary_10_1038_s41551_024_01180_z crossref_primary_10_3390_genes14020474 crossref_primary_10_3892_ol_2023_14070 crossref_primary_10_1111_cas_15290 crossref_primary_10_1016_j_biomaterials_2022_121918 crossref_primary_10_1080_15384101_2024_2311501 crossref_primary_10_3390_cells10092257 crossref_primary_10_3390_ijms26125635 crossref_primary_10_1016_j_archoralbio_2021_105294 crossref_primary_10_1002_mco2_70063 crossref_primary_10_3390_cells13110977 crossref_primary_10_1007_s11864_022_01005_8 crossref_primary_10_3389_fneur_2023_1215876 crossref_primary_10_3390_ijms24010110 crossref_primary_10_1016_j_intimp_2021_107627 crossref_primary_10_3390_cells11213406 crossref_primary_10_1158_1541_7786_MCR_22_0623 crossref_primary_10_3390_cells9041018 crossref_primary_10_1158_1940_6207_CAPR_24_0085 crossref_primary_10_3389_fonc_2024_1400277 crossref_primary_10_1016_j_heliyon_2024_e36681 crossref_primary_10_3390_cancers14030510 crossref_primary_10_1007_s12672_025_02877_6 crossref_primary_10_1016_j_adcanc_2023_100107 crossref_primary_10_3390_biom14020205 crossref_primary_10_3390_immuno1020007 crossref_primary_10_3390_cells9020309 crossref_primary_10_1177_10732748231159313 crossref_primary_10_1002_ctm2_70368 crossref_primary_10_1038_s12276_022_00867_0 crossref_primary_10_3390_cells13242135 crossref_primary_10_3390_microorganisms11020288 crossref_primary_10_1186_s40364_024_00610_z crossref_primary_10_3389_fcell_2022_840171 crossref_primary_10_1097_MD_0000000000034826 crossref_primary_10_1016_j_tice_2024_102679 crossref_primary_10_3390_cancers16203553 crossref_primary_10_3389_fbioe_2021_785937 crossref_primary_10_1016_j_omto_2023_09_001 crossref_primary_10_34172_aim_2022_74 crossref_primary_10_1016_j_bbcan_2021_188587 crossref_primary_10_3390_ijms24076689 crossref_primary_10_1016_j_radonc_2021_02_035 crossref_primary_10_3390_cells14151200 crossref_primary_10_1016_j_jrras_2024_100937 crossref_primary_10_1111_1754_9485_13399 crossref_primary_10_1038_s41571_023_00734_5 crossref_primary_10_3390_cells11121875 crossref_primary_10_3389_fimmu_2020_609961 crossref_primary_10_3390_cancers14051236 crossref_primary_10_3389_fonc_2022_925043 crossref_primary_10_3390_cancers13215333 crossref_primary_10_62347_QFHJ2430 crossref_primary_10_1016_j_jprot_2023_104865 crossref_primary_10_3390_cancers14051359 crossref_primary_10_1016_j_lungcan_2025_108726 crossref_primary_10_3390_cancers14030536 crossref_primary_10_3839_jabc_2022_050 crossref_primary_10_3390_ijms22179260 crossref_primary_10_3390_cancers17071232 crossref_primary_10_1007_s00262_022_03248_8 crossref_primary_10_3389_fonc_2022_947183 crossref_primary_10_3390_cimb46030139 crossref_primary_10_1016_j_surg_2021_11_022 crossref_primary_10_2147_CMAR_S251427 crossref_primary_10_3390_cancers13236027 crossref_primary_10_1038_s41419_024_06976_0 crossref_primary_10_1186_s13045_024_01561_6 crossref_primary_10_1016_j_nut_2025_112697 crossref_primary_10_3390_ijms21218363 crossref_primary_10_1159_000506975 crossref_primary_10_3390_cancers14143391 crossref_primary_10_1097_MD_0000000000033806 crossref_primary_10_3389_frhem_2024_1377806 crossref_primary_10_3390_cancers15133327 crossref_primary_10_3390_cancers17101638 crossref_primary_10_3390_molecules26216367 crossref_primary_10_1111_vco_12679 crossref_primary_10_1016_j_cpt_2025_02_004 crossref_primary_10_3389_fimmu_2025_1544137 crossref_primary_10_1007_s00520_020_05979_9 crossref_primary_10_3390_cancers14102406 crossref_primary_10_3389_fimmu_2023_1170603 crossref_primary_10_3390_cancers14102529 crossref_primary_10_1016_j_lfs_2022_121361 crossref_primary_10_1016_j_ijbiomac_2023_128018 crossref_primary_10_1016_j_jormas_2023_101738 crossref_primary_10_1021_acsnano_4c14487 crossref_primary_10_1016_j_lfs_2022_121125 crossref_primary_10_3390_jcm10194444 crossref_primary_10_3390_cells11111824 crossref_primary_10_1124_pharmrev_123_000901 crossref_primary_10_1038_s41598_024_70916_3 crossref_primary_10_3390_cancers15133339 crossref_primary_10_1080_1061186X_2020_1757102 crossref_primary_10_2217_bmm_2023_0629 crossref_primary_10_1016_j_intimp_2025_114173 crossref_primary_10_3389_fimmu_2023_1292166 crossref_primary_10_1007_s12672_025_02391_9 crossref_primary_10_23736_S0393_0564_24_00017_7 crossref_primary_10_3390_medicina58030365 crossref_primary_10_1016_j_clineuro_2023_107629 crossref_primary_10_1093_pcmedi_pbae020
Cites_doi	10.4049/jimmunol.1500709 10.1016/j.ccr.2011.08.012 10.1023/A:1015997001657 10.1007/s00262-014-1606-z 10.1136/gutjnl-2016-313075 10.1002/jso.24996 10.1155/2015/983698 10.1038/nri2808 10.1136/gut.2007.141556 10.18632/oncotarget.5638 10.1371/journal.pone.0112183 10.1007/s10555-015-9594-9 10.1152/ajpcell.2001.280.4.C814 10.1098/rsob.170006 10.1159/000071561 10.1155/2017/1506824 10.1182/blood-2014-03-453217 10.4161/auto.7.9.16521 10.1189/jlb.72.1.167 10.1038/nri3399 10.1073/pnas.1507294112 10.1387/ijdb.041796go 10.1371/journal.pone.0199740 10.1016/j.coi.2010.01.021 10.1038/nature14407 10.1158/2326-6066.CIR-15-0313 10.1016/j.jhep.2014.08.023 10.4049/jimmunol.149.1.113 10.1007/s10147-018-1250-2 10.1155/2012/720768 10.1038/ncb2788 10.1093/carcin/bgt397 10.1016/j.molcel.2010.09.023 10.1038/sj.onc.1209237 10.1038/nm.2084 10.1016/j.ajpath.2011.05.031 10.1158/1078-0432.CCR-13-1279 10.1016/j.semcancer.2013.02.003 10.18632/oncotarget.2181 10.4049/jimmunol.164.5.2769 10.1158/0008-5472.CAN-09-4442 10.1126/sciimmunol.aaf8943 10.1111/j.1349-7006.2006.00278.x 10.1038/nrc2621 10.1038/ncomms8064 10.3892/ijo.2016.3616 10.1002/ijc.29945 10.1016/j.cca.2014.10.012 10.1016/j.ccr.2004.09.028 10.1002/ijc.28957 10.1158/0008-5472.CAN-08-1921 10.1073/pnas.0706438104 10.1186/s13046-015-0256-0 10.1016/j.ccr.2009.08.014 10.1158/0008-5472.CAN-15-0054 10.3389/fonc.2019.00082 10.1016/j.yexcr.2009.09.003 10.1002/ijc.10775 10.1371/journal.pone.0031524 10.1093/carcin/bgs123 10.15252/embj.201490147 10.1016/j.trecan.2016.12.006 10.1002/ijc.28551 10.1146/annurev-immunol-020711-074942 10.1158/0008-5472.CAN-10-2583 10.1186/1476-4598-12-154 10.1016/j.canlet.2015.07.027 10.1371/journal.pone.0033655 10.1093/jnci/dju124 10.1016/S1040-8428(01)00119-6 10.1002/hep.25907 10.1002/ijc.24448 10.18632/oncotarget.1631 10.1158/1078-0432.CCR-16-2748 10.3892/or.17.1.161 10.1038/nri3175 10.1371/journal.pone.0098259 10.3389/fimmu.2017.00443 10.1016/j.jhep.2015.03.024 10.1002/ijc.25892 10.1016/j.neo.2014.08.013 10.1007/s13277-015-4349-3 10.1038/nri3024 10.1111/j.1365-2613.2009.00641.x 10.1007/s004280000327 10.4049/jimmunol.161.1.342 10.1093/mutage/gep053 10.1016/j.ccr.2006.06.001 10.1038/nm0598-615 10.1038/nature14282 10.1002/ijc.25991 10.1158/2159-8290.CD-15-1157 10.18632/oncotarget.3328 10.1016/j.it.2015.11.008 10.1038/nm.3394 10.1097/00029330-200710020-00007 10.1016/j.critrevonc.2011.06.004 10.1016/j.imbio.2010.01.002 10.1007/s13277-015-3484-1 10.1186/s12943-017-0707-7 10.18632/oncotarget.4478 10.1080/2162402X.2017.1356965 10.1016/S0092-8674(00)00139-2 10.1371/journal.pone.0030806 10.1038/onc.2012.201 10.1038/nature13111 10.1146/annurev-pathol-020712-164023 10.1002/ijc.30076 10.1073/pnas.0601807103 10.1097/MD.0000000000004932 10.1038/bjc.1995.398 10.1038/ni.2109 10.1002/cncr.26511 10.3389/fimmu.2018.00527 10.1016/j.ccr.2009.06.017 10.1007/s10147-017-1180-4 10.1200/JCO.2008.18.9498 10.1038/bjc.2015.180 10.1016/j.celrep.2014.12.039 10.1093/mutage/gel032 10.1073/pnas.1424927112 10.1158/0008-5472.CAN-11-3873 10.1002/1097-0142(19820701)50:1<62::AID-CNCR2820500113>3.0.CO;2-0 10.1038/nnano.2017.54 10.1016/S0002-9440(10)63580-8 10.1097/01.MP.0000020391.98998.6B 10.1007/s00262-013-1476-9 10.1158/0008-5472.CAN-05-1734 10.1158/0008-5472.CAN-05-4128 10.1159/000362959 10.1016/j.yexcr.2004.09.027 10.18632/oncotarget.4106 10.1158/1078-0432.CCR-03-0760 10.1073/pnas.1113744109 10.1158/0008-5472.CAN-15-0125 10.1016/S0002-9440(10)64755-4 10.1002/path.2947 10.1016/j.jhep.2010.08.041 10.4161/15384101.2014.950163 10.1038/sj.neo.7900110 10.1016/j.cell.2019.05.047 10.1038/nature16140 10.1038/sj.onc.1203687 10.1038/cddis.2014.263 10.1038/nature06348 10.1016/j.immuni.2010.11.011 10.1177/039463201102400314 10.1158/2159-8290.CD-12-0527 10.1016/S0002-9440(10)62527-8 10.1007/s00277-018-3276-y
ContentType	Journal Article
Copyright	Copyright © 2019 Masucci, Minopoli and Carriero. Copyright © 2019 Masucci, Minopoli and Carriero. 2019 Masucci, Minopoli and Carriero
Copyright_xml	– notice: Copyright © 2019 Masucci, Minopoli and Carriero. – notice: Copyright © 2019 Masucci, Minopoli and Carriero. 2019 Masucci, Minopoli and Carriero
DBID	AAYXX CITATION NPM 7X8 5PM DOA
DOI	10.3389/fonc.2019.01146
DatabaseName	CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef PubMed MEDLINE - Academic
DatabaseTitleList	PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	2234-943X
ExternalDocumentID	oai_doaj_org_article_688250aed36f486180d333f096ca1f0d PMC6874146 31799175 10_3389_fonc_2019_01146
Genre	Journal Article Review
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EBS EJD EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RNS RPM ACXDI IPNFZ NPM RIG 7X8 5PM
ID	FETCH-LOGICAL-c459t-5ec687e71a273f097ad53b6f33c42eef4969a76970fadbdcd8a68553bc9b0a903
IEDL.DBID	DOA
ISICitedReferencesCount	487
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000499840300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2234-943X
IngestDate	Fri Oct 03 12:50:43 EDT 2025 Tue Sep 30 16:24:32 EDT 2025 Thu Sep 04 20:23:55 EDT 2025 Thu Apr 03 06:59:55 EDT 2025 Sat Nov 29 01:49:13 EST 2025 Tue Nov 18 22:02:42 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	tumor associated neutrophils neutrophil-to-lymphocyte ratio tumor microenvironment tumorigenesis angiogenesis
Language	English
License	Copyright © 2019 Masucci, Minopoli and Carriero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c459t-5ec687e71a273f097ad53b6f33c42eef4969a76970fadbdcd8a68553bc9b0a903
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Giovanna Schiavoni, National Institute of Health (ISS), Italy Reviewed by: Maria Rosaria Galdiero, University of Naples Federico II, Italy; Xu Zhang, Jiangsu University, China This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology
OpenAccessLink	https://doaj.org/article/688250aed36f486180d333f096ca1f0d
PMID	31799175
PQID	2321665233
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_688250aed36f486180d333f096ca1f0d pubmedcentral_primary_oai_pubmedcentral_nih_gov_6874146 proquest_miscellaneous_2321665233 pubmed_primary_31799175 crossref_primary_10_3389_fonc_2019_01146 crossref_citationtrail_10_3389_fonc_2019_01146
PublicationCentury	2000
PublicationDate	2019-11-15
PublicationDateYYYYMMDD	2019-11-15
PublicationDate_xml	– month: 11 year: 2019 text: 2019-11-15 day: 15
PublicationDecade	2010
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	Frontiers in oncology
PublicationTitleAlternate	Front Oncol
PublicationYear	2019
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	McCluney (B142) 2018; 117 Uribe-Querol (B6) 2015; 2015 Jaganjac (B63) 2010; 215 Nakaya (B139) 2018; 23 Benevides (B31) 2015; 75 Gerrard (B59) 1981; 66 Hu (B104) 2015; 36 Zhao (B135) 2012; 7 Gabrilovich (B49) 2012; 12 Mantovani (B8) 2009; 16 Zhang (B12) 2016; 49 Coffelt (B30) 2015; 522 Komura (B137) 2018; 23 Mayadas (B65) 2014; 9 Sandhu (B76) 2000; 156 Loffredo (B72) 2017; 8 Grégoire (B91) 2015; 6 Bodey (B47) 2001; 39 Trellakis (B131) 2011; 129 Riise (B69) 2015; 195 Belaaouaj (B147) 1998; 4 Galli (B48) 2011; 12 Kamohara (B148) 1997; 98 Jensen (B132) 2012; 118 Yao (B22) 2007; 120 Sceneay (B124) 2012; 72 Freisinger (B103) 2014; 9 Knaapen (B78) 2006; 21 Mantovani (B9) 2011; 11 Houghton (B85) 2010; 16 Amulic (B66) 2012; 30 Wislez (B130) 2003; 63 Hirose (B15) 1995; 72 Deryugina (B29) 2014; 16 Zhou (B27) 2012; 56 Fridlender (B51) 2012; 7 Lakritz (B83) 2015; 6 Powell (B74) 2016; 37 Moschetta (B138) 2017; 2017 Kolaczkowska (B67) 2013; 13 Katano (B60) 1982; 50 Scapini (B68) 2014; 124 Yang (B133) 2015; 439 Bodey (B45) 1996; 16 Jensen (B129) 2009; 27 Flavell (B50) 2010; 10 Van Coillie (B16) 2001; 159 Andzinski (B42) 2015; 136 Wu (B58) 2001; 280 Xue (B146) 2017; 12 Schaider (B19) 2003; 103 Campregher (B80) 2008; 57 Colombo (B61) 1992; 149 Andzinski (B154) 2016; 138 Inada (B149) 1997; 97 López-Lago (B70) 2013; 32 Trellakis (B36) 2011; 24 Tazzyman (B110) 2009; 90 Ocana (B155) 2017; 16 He (B128) 2015; 34 Gijsbers (B23) 2005; 303 Shen (B5) 2014; 9 Gregory (B13) 2011; 71 Zhu (B53) 2014; 5 Kuang (B32) 2011; 54 Zhang (B109) 2016; 37 Sparmann (B24) 2004; 6 Liang (B89) 2014; 20 Mishalian (B55) 2013; 62 Wada (B152) 2006; 97 El Rayes (B96) 2015; 112 Piccard (B11) 2012; 82 Ma (B87) 2015; 75 Tazzyman (B113) 2013; 23 Kroemer (B38) 2010; 40 Song (B90) 2015; 368 Templeton (B136) 2014; 106 Wada (B151) 2007; 17 Haqqani (B75) 2000; 2 Dumitru (B99) 2011; 129 Swierczak (B7) 2015; 34 Ardi (B115) 2007; 104 Huh (B107) 2010; 70 Lee (B20) 2000; 164 Albini (B112) 2018; 9 Wu (B98) 2011; 225 Rodriguez (B120) 2009; 69 Bellocq (B21) 1998; 152 Cortez-Retamozo (B33) 2012; 109 Coussens (B82) 2000; 103 Di Carlo (B26) 2003 Sun (B145) 2014; 5 Galdiero (B44) 2018; 13 Degenhardt (B39) 2006; 10 Lin (B100) 2015; 6 Tazawa (B95) 2003; 163 Schott (B156) 2017; 23 Loukinova (B17) 2000; 19 Bald (B34) 2014; 507 Eruslanov (B14) 2017; 3 Galdiero (B71) 2016; 139 Sun (B40) 2011; 7 Fridlender (B4) 2012; 33 Zhou (B28) 2014; 35 Satpathy (B35) 2015; 6 Hu (B54) 2014; 33 Finisguerra (B64) 2015; 522 Nozawa (B116) 2006; 103 Jablonska (B43) 2014; 134 Ponzetta (B73) 2019; 2 De Larco (B105) 2004; 10 Tao (B108) 2016; 95 Wculek (B153) 2015; 528 Granot (B10) 2011; 20 Spiegel (B125) 2016; 6 Condamine (B57) 2016; 1 Psaila (B94) 2009; 9 Liang (B93) 2016; 4 Grosse-Steffen (B102) 2012; 2012 Peranzoni (B122) 2010; 22 Sagiv (B56) 2015; 10 Quail (B143) 2013; 19 Yan (B62) 2014; 3 Gong (B86) 2013; 12 Borregaard (B1) 2010; 33 Güngör (B79) 2010; 25 Knaapen (B77) 2002 Antonio (B88) 2015; 34 Hattar (B84) 2014; 63 Shojaei (B114) 2007; 450 Ingangi (B123) 2019; 9 Li (B41) 2015; 62 Caruso (B46) 2002; 15 Ferrucci (B141) 2015; 112 Bekes (B117) 2011; 179 Pang (B144) 2013; 3 Aarbiou (B92) 2002; 72 Calì (B118) 2017; 7 Ji (B25) 2006; 25 Queen (B97) 2005; 65 Opdenakker (B18) 2004; 48 Song (B101) 2015; 6 Mentzel (B111) 2001; 438 Fioretti (B2) 1998; 161 Kim (B52) 2006; 66 Rao (B134) 2012; 7 Rotondo (B121) 2009; 125 Yan (B81) 2015; 63 Fridlender (B3) 2009; 16 Boya (B37) 2013; 15 Wang (B127) 2017; 66 Ho (B150) 2014; 5 Romano (B140) 2018; 97 Strell (B106) 2010; 316 Michaeli (B119) 2017; 6 Casbon (B126) 2015; 112
References_xml	– volume: 195 start-page: 1121 year: 2015 ident: B69 article-title: TLR-stimulated neutrophils instruct NK cells To trigger dendritic cell maturation and promote adaptive T cell responses publication-title: J Immunol doi: 10.4049/jimmunol.1500709 – volume: 20 start-page: 300 year: 2011 ident: B10 article-title: Tumor entrained neutrophils inhibit seeding in the premetastatic lung publication-title: Cancer Cell doi: 10.1016/j.ccr.2011.08.012 – start-page: 143 year: 2002 ident: B77 article-title: Mechanisms of neutrophil-induced DNA damage in respiratory tract epithelial cells publication-title: Mol Cell Biochem doi: 10.1023/A:1015997001657 – volume: 63 start-page: 1297 year: 2014 ident: B84 article-title: Interactions between neutrophils and non-small cell lung cancer cells: enhancement of tumor proliferation and inflammatory mediator synthesis publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-014-1606-z – volume: 66 start-page: 1900 year: 2017 ident: B127 article-title: Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway publication-title: Gut doi: 10.1136/gutjnl-2016-313075 – volume: 117 start-page: 1058 year: 2018 ident: B142 article-title: Neutrophil: Lymphocyte ratio as a method of predicting complications following hepatic resection for colorectal liver metastasis publication-title: J Surg Oncol doi: 10.1002/jso.24996 – volume: 98 start-page: 103 year: 1997 ident: B148 article-title: Neutrophil elastase inhibitor (ONO-5046.Na) suppresses the proliferation, motility and chemotaxis of a pancreatic carcinoma cell line, Capan-1 publication-title: Res Commun Mol Pathol Pharmacol – volume: 2015 start-page: 983698 year: 2015 ident: B6 article-title: Neutrophils in cancer: two sides of the same coin publication-title: J Immunol Res. doi: 10.1155/2015/983698 – volume: 10 start-page: 554 year: 2010 ident: B50 article-title: The polarization of immune cells in the tumour environment by TGFbeta publication-title: Nat Rev Immunol doi: 10.1038/nri2808 – volume: 57 start-page: 780 year: 2008 ident: B80 article-title: Activated neutrophils induce an hMSH2-dependent G2/M checkpoint arrest and replication errors at a (CA)13-repeat in colon epithelial cells publication-title: Gut doi: 10.1136/gut.2007.141556 – volume: 6 start-page: 43081 year: 2015 ident: B100 article-title: Infiltrating neutrophils increase bladder cancer cell invasion via modulation of androgen receptor (AR)/MMP13 signals publication-title: Oncotarget doi: 10.18632/oncotarget.5638 – volume: 9 start-page: e112183 year: 2014 ident: B103 article-title: Live imaging and gene expression analysis in zebrafish identifies a link between neutrophils and epithelial to mesenchymal transition publication-title: PLoS ONE. doi: 10.1371/journal.pone.0112183 – volume: 34 start-page: 735 year: 2015 ident: B7 article-title: Neutrophils: important contributors to tumor progression and metastasis publication-title: Cancer Metastasis Rev doi: 10.1007/s10555-015-9594-9 – volume: 280 start-page: C814 year: 2001 ident: B58 article-title: Human neutrophils facilitate tumor cell transendothelial migration publication-title: Am J Physiol Cell Physiol doi: 10.1152/ajpcell.2001.280.4.C814 – volume: 7 start-page: 170006 year: 2017 ident: B118 article-title: Tuning cancer fate: the unremitting role of host immunity publication-title: Open Biol doi: 10.1098/rsob.170006 – start-page: 83182 year: 2003 ident: B26 article-title: Neutrophils in the antitumoral immune response publication-title: Chem Immunol Allergy doi: 10.1159/000071561 – volume: 2017 start-page: 1506824 year: 2017 ident: B138 article-title: Dynamics of neutrophils-to-lymphocyte ratio predict outcomes of PD-1/PD-L1 blockade publication-title: Biomed Res Int. doi: 10.1155/2017/1506824 – volume: 124 start-page: 710 year: 2014 ident: B68 article-title: Social networking of human neutrophils within the immune system publication-title: Blood doi: 10.1182/blood-2014-03-453217 – volume: 7 start-page: 1035 year: 2011 ident: B40 article-title: Autophagy protects breast cancer cells from epirubicin-induced apoptosis and facilitates epirubicin-resistance development publication-title: Autophagy doi: 10.4161/auto.7.9.16521 – volume: 72 start-page: 167 year: 2002 ident: B92 article-title: Human neutrophil defensins induce lung epithelial cell proliferation in vitro publication-title: J Leukoc Biol doi: 10.1189/jlb.72.1.167 – volume: 13 start-page: 159 year: 2013 ident: B67 article-title: Neutrophil recruitment and function in health and inflammation publication-title: Nat Rev Immunol doi: 10.1038/nri3399 – volume: 112 start-page: 16000 year: 2015 ident: B96 article-title: Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1507294112 – volume: 48 start-page: 519 year: 2004 ident: B18 article-title: The countercurrent principle in invasion and metastasis of cancer cells publication-title: Int J Dev Biol doi: 10.1387/ijdb.041796go – volume: 13 start-page: e0199740 year: 2018 ident: B44 article-title: Potential involvement of neutrophils in human thyroid cancer publication-title: PLoS ONE doi: 10.1371/journal.pone.0199740 – volume: 22 start-page: 238 year: 2010 ident: B122 article-title: Myeloid-derived suppressor cell heterogeneity and subset definition publication-title: Curr. Opin. Immunol. doi: 10.1016/j.coi.2010.01.021 – volume: 522 start-page: 349 year: 2015 ident: B64 article-title: MET is required for the recruitment of anti-tumoural neutrophils publication-title: Nature doi: 10.1038/nature14407 – volume: 4 start-page: 83 year: 2016 ident: B93 article-title: The complex role of neutrophils in tumor angiogenesis and metastasis publication-title: Cancer Immunol Res doi: 10.1158/2326-6066.CIR-15-0313 – volume: 62 start-page: 131 year: 2015 ident: B41 article-title: Increased autophagy sustains the survival and pro-tumourigenic effects of neutrophils in human hepatocellular carcinoma publication-title: J Hepatol doi: 10.1016/j.jhep.2014.08.023 – volume: 149 start-page: 113 year: 1992 ident: B61 article-title: Granulocyte colony-stimulating factor (G-CSF) gene transduction in murine adenocarcinoma drives neutrophil-mediated tumor inhibition in vivo publication-title: J Immunol doi: 10.4049/jimmunol.149.1.113 – volume: 23 start-page: 634 year: 2018 ident: B139 article-title: Neutrophil-to-lymphocyte ratio as an early marker of outcomes in patients with advanced non-small-cell lung cancer treated with nivolumab publication-title: Int J Clin Oncol doi: 10.1007/s10147-018-1250-2 – volume: 2012 start-page: 720768 year: 2012 ident: B102 article-title: Epithelial-to-mesenchymal transition in pancreatic ductal adenocarcinoma and pancreatic tumor cell lines: the role of neutrophils and neutrophil-derived elastase publication-title: Clin Dev Immunol doi: 10.1155/2012/720768 – volume: 15 start-page: 713 year: 2013 ident: B37 article-title: Emerging regulation and functions of autophagy publication-title: Nat Cell Biol. doi: 10.1038/ncb2788 – volume: 35 start-page: 597 year: 2014 ident: B28 article-title: CXCL5 contributes to tumor metastasis and recurrence of intrahepatic cholangiocarcinoma by recruiting infiltrative intratumoral neutrophils publication-title: Carcinogenesis doi: 10.1093/carcin/bgt397 – volume: 40 start-page: 280 year: 2010 ident: B38 article-title: Autophagy and the integrated stress response publication-title: Mol Cell. doi: 10.1016/j.molcel.2010.09.023 – volume: 25 start-page: 2105 year: 2006 ident: B25 article-title: K-ras activation generates an inflammatory response in lung tumors publication-title: Oncogene doi: 10.1038/sj.onc.1209237 – volume: 16 start-page: 219 year: 2010 ident: B85 article-title: Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth publication-title: Nat Med doi: 10.1038/nm.2084 – volume: 179 start-page: 1455 year: 2011 ident: B117 article-title: Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation publication-title: Am J Pathol doi: 10.1016/j.ajpath.2011.05.031 – volume: 20 start-page: 187 year: 2014 ident: B89 article-title: Neutrophils promote the malignant glioma phenotype through S100A4 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-13-1279 – volume: 23 start-page: 149 year: 2013 ident: B113 article-title: Neutrophil-mediated tumour angiogenesis: subversion of immune responses to promote tumour growth publication-title: Semin Cancer Biol doi: 10.1016/j.semcancer.2013.02.003 – volume: 5 start-page: 12621 year: 2014 ident: B145 article-title: Neutrophils with protumor potential could efficiently suppress tumor growth after cytokine priming and in presence of normal NK cells publication-title: Oncotarget doi: 10.18632/oncotarget.2181 – volume: 164 start-page: 2769 year: 2000 ident: B20 article-title: IL-8 reduced tumorigenicity of human ovarian cancer in vivo due to neutrophil infiltration publication-title: J Immunol doi: 10.4049/jimmunol.164.5.2769 – volume: 70 start-page: 6071 year: 2010 ident: B107 article-title: Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-4442 – volume: 1 start-page: aaf8943 year: 2016 ident: B57 article-title: Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients publication-title: Sci Immunol doi: 10.1126/sciimmunol.aaf8943 – volume: 97 start-page: 1037 year: 2006 ident: B152 article-title: Sivelestat, a specific neutrophil elastase inhibitor, suppresses the growth of gastric carcinoma cells by preventing the release of transforming growth factor-alpha publication-title: Cancer Sci doi: 10.1111/j.1349-7006.2006.00278.x – volume: 9 start-page: 285 year: 2009 ident: B94 article-title: The metastatic niche: adapting the foreign soil publication-title: Nat Rev Cancer doi: 10.1038/nrc2621 – volume: 6 start-page: 7064 year: 2015 ident: B35 article-title: Crystalline silica-induced leukotriene B4-dependent inflammation promotes lung tumour growth publication-title: Nat Commun. doi: 10.1038/ncomms8064 – volume: 49 start-page: 857 year: 2016 ident: B12 article-title: Neutrophils in cancer development and progression: roles, mechanisms, and implications (Review) publication-title: Int J Oncol doi: 10.3892/ijo.2016.3616 – volume: 138 start-page: 1982 year: 2016 ident: B154 article-title: Type I IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human publication-title: Int J Cancer doi: 10.1002/ijc.29945 – volume: 439 start-page: 172 year: 2015 ident: B133 article-title: Elevated levels of preoperative circulating CD44+ lymphocytes and neutrophils predict poor survival for non-small cell lung cancer patients publication-title: Clin Chim Acta doi: 10.1016/j.cca.2014.10.012 – volume: 97 start-page: 229 year: 1997 ident: B149 article-title: Neutrophil elastase inhibitor (ONO-5046-Na) inhibits the growth of human lung cancer cell lines transplanted into severe combined immunodeficiency (scid) mice publication-title: Res Commun Mol Pathol Pharmacol – volume: 6 start-page: 447 year: 2004 ident: B24 article-title: Ras-induced interleukin-8 expression plays a critical role in tumor growth and angiogenesis publication-title: Cancer Cell doi: 10.1016/j.ccr.2004.09.028 – volume: 136 start-page: 572 year: 2015 ident: B42 article-title: Delayed apoptosis of tumor associated neutrophils in the absence of endogenous IFN-β publication-title: Int J Cancer doi: 10.1002/ijc.28957 – volume: 69 start-page: 1553 year: 2009 ident: B120 article-title: Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-08-1921 – volume: 104 start-page: 20262 year: 2007 ident: B115 article-title: Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0706438104 – volume: 34 start-page: 141 year: 2015 ident: B128 article-title: Peritumoural neutrophils negatively regulate adaptive immunity via the PD-L1/PD-1 signalling pathway in hepatocellular carcinoma publication-title: J Exp Clin Cancer Res doi: 10.1186/s13046-015-0256-0 – volume: 16 start-page: 173 year: 2009 ident: B8 article-title: The yin-yang of tumor-associated neutrophils publication-title: Cancer Cell doi: 10.1016/j.ccr.2009.08.014 – volume: 75 start-page: 3788 year: 2015 ident: B31 article-title: IL17 promotes mammary tumor progression by changing the behavior of tumor cells and eliciting tumorigenic neutrophils recruitment publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-15-0054 – volume: 9 start-page: 82 year: 2019 ident: B123 article-title: Role of microenvironment on the fate of disseminating cancer stem cells publication-title: Front Oncol doi: 10.3389/fonc.2019.00082 – volume: 316 start-page: 138 year: 2010 ident: B106 article-title: Neutrophil granulocytes promote the migratory activity of MDA-MB-468 human breast carcinoma cells via ICAM-1 publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2009.09.003 – volume: 103 start-page: 335 year: 2003 ident: B19 article-title: Differential response of primary and metastatic melanomas to neutrophils attracted by IL-8 publication-title: Int J Cancer. doi: 10.1002/ijc.10775 – volume: 7 start-page: e31524 year: 2012 ident: B51 article-title: Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils publication-title: PLoS ONE doi: 10.1371/journal.pone.0031524 – volume: 33 start-page: 949 year: 2012 ident: B4 article-title: Tumor-associated neutrophils: friend or foe? publication-title: Carcinogenesis. doi: 10.1093/carcin/bgs123 – volume: 34 start-page: 2219 year: 2015 ident: B88 article-title: The wound inflammatory response exacerbates growth of pre-neoplastic cells and progression to cancer publication-title: EMBO J doi: 10.15252/embj.201490147 – volume: 3 start-page: 149 year: 2017 ident: B14 article-title: Mouse versus human neutrophilsin cancer: a major knowledge gap publication-title: Trends Cancer. doi: 10.1016/j.trecan.2016.12.006 – volume: 134 start-page: 1346 year: 2014 ident: B43 article-title: CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β publication-title: Int J Cancer doi: 10.1002/ijc.28551 – volume: 30 start-page: 459 year: 2012 ident: B66 article-title: Neutrophil function: from mechanisms to disease publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-020711-074942 – volume: 71 start-page: 2411 year: 2011 ident: B13 article-title: Tumor-associated neutrophils: new targets for cancer therapy publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-2583 – volume: 12 start-page: 154 year: 2013 ident: B86 article-title: Promoting effect of neutrophils on lung tumorigenesis is mediated by CXCR2 and neutrophil elastase publication-title: Mol Cancer doi: 10.1186/1476-4598-12-154 – volume: 368 start-page: 71 year: 2015 ident: B90 article-title: Infiltrating neutrophils promote renal cell carcinoma (RCC) proliferation via modulating androgen receptor (AR) → c-Myc signals publication-title: Cancer Lett doi: 10.1016/j.canlet.2015.07.027 – volume: 7 start-page: e33655 year: 2012 ident: B135 article-title: The prognostic value of tumor-infiltrating neutrophils in gastric adenocarcinoma after resection publication-title: PLoS ONE doi: 10.1371/journal.pone.0033655 – volume: 66 start-page: 483 year: 1981 ident: B59 article-title: Human neutrophil-mediated cytotoxicity to tumor cells publication-title: J Natl Cancer Inst – volume: 106 start-page: dju124 year: 2014 ident: B136 article-title: Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis publication-title: J Natl Cancer Inst doi: 10.1093/jnci/dju124 – volume: 39 start-page: 3 year: 2001 ident: B47 article-title: Immunocytochemical detection of leukocyte-associated and apoptosis-related antigen expression in childhood brain tumors publication-title: Crit Rev Oncol Hematol doi: 10.1016/S1040-8428(01)00119-6 – volume: 56 start-page: 2242 year: 2012 ident: B27 article-title: Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma publication-title: Hepatology doi: 10.1002/hep.25907 – volume: 125 start-page: 887 year: 2009 ident: B121 article-title: IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer publication-title: Int J Cancer doi: 10.1002/ijc.24448 – volume: 5 start-page: 473 year: 2014 ident: B150 article-title: Neutrophil elastase as a diagnostic marker and therapeutic target in colorectal cancers publication-title: Oncotarget doi: 10.18632/oncotarget.1631 – volume: 23 start-page: 5358 year: 2017 ident: B156 article-title: Phase Ib pilot study to evaluate reparixin in combination with weekly paclitaxel in patients with HER-2-negative metastatic breast cancer publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-16-2748 – volume: 17 start-page: 161 year: 2007 ident: B151 article-title: Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines publication-title: Oncol Rep doi: 10.3892/or.17.1.161 – volume: 12 start-page: 253 year: 2012 ident: B49 article-title: Coordinated regulation of myeloid cells by tumours publication-title: Nat Rev Immunol doi: 10.1038/nri3175 – volume: 9 start-page: e98259 year: 2014 ident: B5 article-title: Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis publication-title: PLoS ONE doi: 10.1371/journal.pone.0098259 – volume: 8 start-page: 443 year: 2017 ident: B72 article-title: Group V secreted phospholipase A2 induces the release of proangiogenic and antiangiogenic factors by human neutrophils publication-title: Front Immunol. doi: 10.3389/fimmu.2017.00443 – volume: 63 start-page: 420 year: 2015 ident: B81 article-title: Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish publication-title: J Hepatol doi: 10.1016/j.jhep.2015.03.024 – volume: 129 start-page: 2183 year: 2011 ident: B131 article-title: Polymorphonuclear granulocytes in human head and neck cancer: enhanced inflammatory activity, modulation by cancer cells and expansion in advanced disease publication-title: Int J Cancer doi: 10.1002/ijc.25892 – volume: 16 start-page: 771 year: 2014 ident: B29 article-title: Tissue-infiltrating neutrophils constitute the major in vivo source of angiogenesis-inducing MMP-9 in the tumor microenvironment publication-title: Neoplasia doi: 10.1016/j.neo.2014.08.013 – volume: 37 start-page: 5397 year: 2016 ident: B109 article-title: Circulating tumor-associated neutrophils (cTAN) contribute to circulating tumor cell survival by suppressing peripheral leukocyte activation publication-title: Tumour Biol doi: 10.1007/s13277-015-4349-3 – volume: 11 start-page: 519 year: 2011 ident: B9 article-title: Neutrophils in the activation and regulation of innate and adaptive immunity publication-title: Nat Rev Immunol doi: 10.1038/nri3024 – volume: 90 start-page: 222 year: 2009 ident: B110 article-title: Neutrophils: key mediators of tumour angiogenesis publication-title: Int J Exp Pathol doi: 10.1111/j.1365-2613.2009.00641.x – volume: 438 start-page: 13 year: 2001 ident: B111 article-title: The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma publication-title: Virchows Arch doi: 10.1007/s004280000327 – volume: 161 start-page: 342 year: 1998 ident: B2 article-title: Reduced tumorigenicity and augmented leukocyte infiltration after monocyte chemotactic protein-3 (MCP-3) gene transfer: perivascular accumulation of dendritic cells in peritumoral tissue and neutrophil recruitment within the tumor publication-title: J Immunol doi: 10.4049/jimmunol.161.1.342 – volume: 25 start-page: 149 year: 2010 ident: B79 article-title: Genotoxic effects of neutrophils and hypochlorous acid publication-title: Mutagenesis doi: 10.1093/mutage/gep053 – volume: 10 start-page: 51 year: 2006 ident: B39 article-title: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis publication-title: Cancer Cell doi: 10.1016/j.ccr.2006.06.001 – volume: 4 start-page: 615 year: 1998 ident: B147 article-title: Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis publication-title: Nat Med. doi: 10.1038/nm0598-615 – volume: 522 start-page: 345 year: 2015 ident: B30 article-title: IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis publication-title: Nature doi: 10.1038/nature14282 – volume: 129 start-page: 859 year: 2011 ident: B99 article-title: Tumor-derived macrophage migration inhibitory factor modulates the biology of head and neck cancer cells via neutrophil activation publication-title: Int J Cancer doi: 10.1002/ijc.25991 – volume: 6 start-page: 630 year: 2016 ident: B125 article-title: Neutrophils suppress intraluminal NK cell-mediated tumor cell clearance and enhance extravasation of disseminated carcinoma cells publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-15-1157 – volume: 6 start-page: 9387 year: 2015 ident: B83 article-title: Gut bacteria require neutrophils to promote mammary tumorigenesis publication-title: Oncotarget doi: 10.18632/oncotarget.3328 – volume: 37 start-page: 41 year: 2016 ident: B74 article-title: Neutrophils in the tumor microenvironment publication-title: Trends Immunol. doi: 10.1016/j.it.2015.11.008 – volume: 19 start-page: 1423 year: 2013 ident: B143 article-title: Microenvironmental regulation of tumor progression and metastasis publication-title: Nat Med doi: 10.1038/nm.3394 – volume: 120 start-page: 1766 year: 2007 ident: B22 article-title: Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer publication-title: Chin Med J doi: 10.1097/00029330-200710020-00007 – volume: 82 start-page: 296 year: 2012 ident: B11 article-title: On the dual roles and polarized phenotypes of neutrophils in tumor development and progression publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2011.06.004 – volume: 215 start-page: 1015 year: 2010 ident: B63 article-title: Granulocytes as effective anticancer agent in experimental solid tumor models publication-title: Immunobiology doi: 10.1016/j.imbio.2010.01.002 – volume: 36 start-page: 7789 year: 2015 ident: B104 article-title: Intratumoral neutrophil granulocytes contribute to epithelial-mesenchymal transition in lung adenocarcinoma cells publication-title: Tumour Biol doi: 10.1007/s13277-015-3484-1 – volume: 16 start-page: 137 year: 2017 ident: B155 article-title: Neutrophils in cancer: prognostic role and therapeutic strategies publication-title: Mol Cancer doi: 10.1186/s12943-017-0707-7 – volume: 6 start-page: 19290 year: 2015 ident: B101 article-title: Infiltrating neutrophils promote renal cell carcinoma progression via VEGFa/HIF2α and estrogen receptor β signals publication-title: Oncotarget. doi: 10.18632/oncotarget.4478 – volume: 6 start-page: e1356965 year: 2017 ident: B119 article-title: Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment publication-title: Oncoimmunology doi: 10.1080/2162402X.2017.1356965 – volume: 103 start-page: 481 year: 2000 ident: B82 article-title: MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis publication-title: Cell doi: 10.1016/S0092-8674(00)00139-2 – volume: 7 start-page: e30806 year: 2012 ident: B134 article-title: Increased intratumoral neutrophil in colorectal carcinomas correlates closely with malignant phenotype and predicts patients' adverse prognosis publication-title: PLoS ONE doi: 10.1371/journal.pone.0030806 – volume: 32 start-page: 1752 year: 2013 ident: B70 article-title: Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression publication-title: Oncogene doi: 10.1038/onc.2012.201 – volume: 507 start-page: 109 year: 2014 ident: B34 article-title: Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma publication-title: Nature. doi: 10.1038/nature13111 – volume: 9 start-page: 181 year: 2014 ident: B65 article-title: The multifaceted functions of neutrophils publication-title: Annu Rev Pathol doi: 10.1146/annurev-pathol-020712-164023 – volume: 139 start-page: 446 year: 2016 ident: B71 article-title: Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer publication-title: Int J Cancer. doi: 10.1002/ijc.30076 – volume: 103 start-page: 12493 year: 2006 ident: B116 article-title: Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.0601807103 – volume: 95 start-page: e4932 year: 2016 ident: B108 article-title: Neutrophils assist the metastasis of circulating tumor cells in pancreatic ductal adenocarcinoma: A new hypothesis and a new predictor for distant metastasis publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000004932 – volume: 72 start-page: 708 year: 1995 ident: B15 article-title: Chemokine gene transfection into tumour cells reduced tumorigenicity in nude mice in association with neutrophilic infiltration publication-title: Br J Cancer doi: 10.1038/bjc.1995.398 – volume: 12 start-page: 1035 year: 2011 ident: B48 article-title: Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils publication-title: Nat Immunol doi: 10.1038/ni.2109 – volume: 118 start-page: 2476 year: 2012 ident: B132 article-title: Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma publication-title: Cancer doi: 10.1002/cncr.26511 – volume: 9 start-page: 527 year: 2018 ident: B112 article-title: Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy publication-title: Front Immunol doi: 10.3389/fimmu.2018.00527 – volume: 16 start-page: 183 year: 2009 ident: B3 article-title: Polarization of tumor-associated neutrophil phenotype by TGF-beta: N1 versus N2 TAN publication-title: Cancer Cell. doi: 10.1016/j.ccr.2009.06.017 – volume: 23 start-page: 104 year: 2018 ident: B137 article-title: Comparison of clinical utility between neutrophil count and neutrophil-lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review publication-title: Int J Clin Oncol doi: 10.1007/s10147-017-1180-4 – volume: 27 start-page: 4709 year: 2009 ident: B129 article-title: Presence of intratumoral neutrophils is an independent prognostic factor in localized renal cell carcinoma publication-title: J Clin Oncol doi: 10.1200/JCO.2008.18.9498 – volume: 112 start-page: 1904 year: 2015 ident: B141 article-title: Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab-treated metastatic melanoma patients publication-title: Br J Cancer doi: 10.1038/bjc.2015.180 – volume: 10 start-page: 562 year: 2015 ident: B56 article-title: Phenotypic diversity and plasticity in circulating neutrophil subpopulations in cancer publication-title: Cell Rep doi: 10.1016/j.celrep.2014.12.039 – volume: 21 start-page: 225 year: 2006 ident: B78 article-title: Neutrophils and respiratory tract DNA damage and mutagenesis: a review publication-title: Mutagenesis doi: 10.1093/mutage/gel032 – volume: 112 start-page: E566 year: 2015 ident: B126 article-title: Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.1424927112 – volume: 72 start-page: 3906 year: 2012 ident: B124 article-title: Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-11-3873 – volume: 50 start-page: 62 year: 1982 ident: B60 article-title: Neutrophil-mediated tumor cell destruction in cancer ascites publication-title: Cancer. doi: 10.1002/1097-0142(19820701)50:1<62::AID-CNCR2820500113>3.0.CO;2-0 – volume: 12 start-page: 692 year: 2017 ident: B146 article-title: Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence publication-title: Nat Nanotechnol doi: 10.1038/nnano.2017.54 – volume: 163 start-page: 2221 year: 2003 ident: B95 article-title: Infiltration of neutrophils is required for acquisition of metastatic phenotype of benign murine fibrosarcoma cells: implication of inflammation-associated carcinogenesis and tumor progression publication-title: Am J Pathol. doi: 10.1016/S0002-9440(10)63580-8 – volume: 15 start-page: 831 year: 2002 ident: B46 article-title: Prognostic value of intratumoral neutrophils in advanced gastric carcinoma in a high-risk area in northern Italy publication-title: Mod Pathol doi: 10.1097/01.MP.0000020391.98998.6B – volume: 62 start-page: 1745 year: 2013 ident: B55 article-title: Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-013-1476-9 – volume: 65 start-page: 8896 year: 2005 ident: B97 article-title: Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-05-1734 – volume: 66 start-page: 5527 year: 2006 ident: B52 article-title: Tumor-driven evolution of immunosuppressive networks during malignant progression publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-05-4128 – volume: 33 start-page: 1802 year: 2014 ident: B54 article-title: Programming of the development of tumor-promoting neutrophils by mesenchymal stromal cells publication-title: Cell Physiol Biochem doi: 10.1159/000362959 – volume: 303 start-page: 331 year: 2005 ident: B23 article-title: GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors publication-title: Exp Cell Res doi: 10.1016/j.yexcr.2004.09.027 – volume: 152 start-page: 83 year: 1998 ident: B21 article-title: Neutrophil alveolitis in bronchioloalveolar carcinoma: induction by tumor-derived interleukin-8 and relation to clinical outcome publication-title: Am J Pathol – volume: 6 start-page: 16471 year: 2015 ident: B91 article-title: Neutrophils trigger a NF-κB dependent polarization of tumor-supportive stromal cells in germinal center B-cell lymphomas publication-title: Oncotarget doi: 10.18632/oncotarget.4106 – volume: 10 start-page: 4895 year: 2004 ident: B105 article-title: The potential role of neutrophils in promoting the metastatic phenotype of tumors releasing interleukin-8 publication-title: Clin Cancer Res doi: 10.1158/1078-0432.CCR-03-0760 – volume: 109 start-page: 2491 year: 2012 ident: B33 article-title: Origins of tumor-associated macrophages and neutrophils publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.1113744109 – volume: 75 start-page: 2822 year: 2015 ident: B87 article-title: Definition of prostaglandin E2-EP2 signals in the colon tumor microenvironment that amplify inflammation and tumor growth publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-15-0125 – volume: 156 start-page: 509 year: 2000 ident: B76 article-title: Neutrophils, nitric oxide synthase, and mutations in the mutatect murine tumor model publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)64755-4 – volume: 225 start-page: 438 year: 2011 ident: B98 article-title: Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop publication-title: J Pathol doi: 10.1002/path.2947 – volume: 54 start-page: 948 year: 2011 ident: B32 article-title: Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma publication-title: J Hepatol doi: 10.1016/j.jhep.2010.08.041 – volume: 3 start-page: e950163 year: 2014 ident: B62 article-title: Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells publication-title: Oncoimmunology doi: 10.4161/15384101.2014.950163 – volume: 2 start-page: 561 year: 2000 ident: B75 article-title: Expression of interleukin-8 promotes neutrophil infiltration and genetic instability in mutatect tumors publication-title: Neoplasia doi: 10.1038/sj.neo.7900110 – volume: 2 start-page: 346 year: 2019 ident: B73 article-title: Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors publication-title: Cell doi: 10.1016/j.cell.2019.05.047 – volume: 528 start-page: 413 year: 2015 ident: B153 article-title: Neutrophils support lung colonization of metastasis-initiating breast cancer cells publication-title: Nature doi: 10.1038/nature16140 – volume: 19 start-page: 3477 year: 2000 ident: B17 article-title: Growth regulated oncogene-alpha expression by murine squamous cell carcinoma promotes tumor growth, metastasis, leukocyte infiltration and angiogenesis by a host CXC receptor-2 dependent mechanism publication-title: Oncogene doi: 10.1038/sj.onc.1203687 – volume: 5 start-page: e1295 year: 2014 ident: B53 article-title: The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression publication-title: Cell Death Dis doi: 10.1038/cddis.2014.263 – volume: 450 start-page: 825 year: 2007 ident: B114 article-title: Bv8 regulates myeloid-cell-dependent tumour angiogenesis publication-title: Nature doi: 10.1038/nature06348 – volume: 33 start-page: 657 year: 2010 ident: B1 article-title: Neutrophils, from marrow to microbes publication-title: Immunity doi: 10.1016/j.immuni.2010.11.011 – volume: 24 start-page: 683 year: 2011 ident: B36 article-title: Peripheral blood neutrophil granulocytes from patients with head and neck squamous cell carcinoma functionally differ from their counterparts in healthy donors publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463201102400314 – volume: 16 start-page: 3439 year: 1996 ident: B45 article-title: Immunophenotypic characterization of human primary and metastatic melanoma infiltrating leukocytes publication-title: Anticancer Res – volume: 63 start-page: 1405 year: 2003 ident: B130 article-title: Hepatocyte growth factor production by neutrophils infiltrating bronchioloalveolar subtype pulmonary adenocarcinoma: role in tumor progression and death publication-title: Cancer Res – volume: 3 start-page: 936 year: 2013 ident: B144 article-title: TGF-β signaling in myeloid cells is required for tumor metastasis publication-title: Cancer Discov doi: 10.1158/2159-8290.CD-12-0527 – volume: 159 start-page: 1405 year: 2001 ident: B16 article-title: Tumor angiogenesis induced by granulocyte chemotactic protein-2 as a countercurrent principle publication-title: Am J Pathol doi: 10.1016/S0002-9440(10)62527-8 – volume: 97 start-page: 1009 year: 2018 ident: B140 article-title: Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy publication-title: Ann Hematol doi: 10.1007/s00277-018-3276-y
SSID	ssj0000650103
Score	2.6522863
SecondaryResourceType	review_article
Snippet	Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by cytokines and chemokines, can be distinguished according to their activation...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	1146
SubjectTerms	angiogenesis neutrophil-to-lymphocyte ratio Oncology tumor associated neutrophils tumor microenvironment tumorigenesis
Title	Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy
URI	https://www.ncbi.nlm.nih.gov/pubmed/31799175 https://www.proquest.com/docview/2321665233 https://pubmed.ncbi.nlm.nih.gov/PMC6874146 https://doaj.org/article/688250aed36f486180d333f096ca1f0d
Volume	9
WOSCitedRecordID	wos000499840300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: DOA dateStart: 20110101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2234-943X dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000650103 issn: 2234-943X databaseCode: M~E dateStart: 20110101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Li9RAEG50EfGy-Da7urTgwYOZTdJJP44qu3iZYZER5iCEfrKBMVmSzB73t29VkhlmRPHiJYSkOmm-qu58RXe-IuSDkCblic1jB-lVnBfSwJAqdGxEMFnqIILUWGxCLBZytVJXe6W-cE_YKA88AnfOgQIWifaO8ZBLnsrEMcYCMG-r05A4nH2B9ewlU-McXGABg1HLB7IwdR6aGhULUzXDFIAffIYGtf4_Uczfd0rufXoun5LjiTPSz2Nfn5EHvn5OHs-nVfEX5Ody86tp6RZp7-jCb_q2ubmu1t2MLnEtgH5v1p5WNR1sUYLTd1X3ic59r4EgDudXbYPb7qqO6tphM9QbeEl-XF4sv36Lp6oJsc0L1ceFt1wKL1INzARwEtoVzPDAmM0z70OuuNKCK5EE7YyzTmouCzCxyiRaJewVOaqb2r8hVAV4hDVA8nSWa5aYDNitcUFLnQVmdERmWxBLO0mKY2WLdQmpBaJeIuolol4OqEfk467Bzaim8XfTL-iVnRnKYA8XIDjKKTjKfwVHRN5vfVrCsMG1EF37ZtOVQCRTziELZxF5Pfp49yqGKnlAqyIiDrx_0JfDO3V1PUhzA_I5dP7kf3T-lDxBOPDHx7R4S476duPfkUf2tq-69ow8FCt5NkQ9HOd3F_fGfwf4
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Tumor+Associated+Neutrophils.+Their+Role+in+Tumorigenesis%2C+Metastasis%2C+Prognosis+and+Therapy&rft.jtitle=Frontiers+in+oncology&rft.au=Masucci%2C+Maria+Teresa&rft.au=Minopoli%2C+Michele&rft.au=Carriero%2C+Maria+Vincenza&rft.date=2019-11-15&rft.issn=2234-943X&rft.eissn=2234-943X&rft.volume=9&rft_id=info:doi/10.3389%2Ffonc.2019.01146&rft.externalDBID=n%2Fa&rft.externalDocID=10_3389_fonc_2019_01146
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2234-943X&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2234-943X&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2234-943X&client=summon