Recent synthesis of aminophosphonic acids as potential biological importance

Aminophosphonic acids are an important group of medicinal compounds, and their synthesis has been a focus of considerable attention in synthetic organic chemistry as well as medicinal chemistry. Although the phosphonic and carboxylic acid groups differ considerably with respect to shape, size, and a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Amino acids Jg. 38; H. 1; S. 23 - 30
Hauptverfasser: Naydenova, Emilia D, Todorov, Petar T, Troev, Kolio D
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Vienna Vienna : Springer Vienna 2010
Springer Vienna
Springer Nature B.V
Schlagworte:
Acidity
acids
Amino acids
Analytical Chemistry
Animals
bioactive properties
Biochemical Engineering
Biochemistry
Biological
Biological activity
Biomedical and Life Sciences
Carboxylic acids
Chemistry, Pharmaceutical
Derivatives
Glycine
Humans
Hydrolysis
Life Sciences
Molecular Structure
Neurobiology
Organic chemistry
Organophosphonates - chemical synthesis
Organophosphonates - chemistry
Organophosphonates - pharmacology
Pharmaceutical industry
Proteomics
Review Article
Synthesis
α-Aminophosphonic acids
Dimethyl-H-phosphonate
Phosphorus trichloride
(phosphonomethyl) glycine
Biological activity
ISSN:0939-4451, 1438-2199, 1438-2199
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aminophosphonic acids are an important group of medicinal compounds, and their synthesis has been a focus of considerable attention in synthetic organic chemistry as well as medicinal chemistry. Although the phosphonic and carboxylic acid groups differ considerably with respect to shape, size, and acidity, α-aminophosphonic acids are considered to be structural analogues of the corresponding amino acids and the transition state mimics peptide hydrolysis. This review summarizes recent developments in the synthesis, characterization and biological activity of α-aminophosphonic acid and N-analogues. An account of both uses will be presented, emphasizing one of the potential future developments, and some implications in medicinal chemistry are also disclosed. In addition, a brief account on the characterization of N-(phosphonomethyl) glycine derivatives will be presented.
Bibliographie:http://dx.doi.org/10.1007/s00726-009-0254-7
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
ObjectType-Review-3
ISSN:0939-4451
1438-2199
1438-2199
DOI:10.1007/s00726-009-0254-7