Dimerization allows DNA target site recognition by the NarL response regulator

Two-component signal transduction systems are modular phosphorelay regulatory pathways common in prokaryotes. In the co-crystal structure of the Escherichia coli NarL signal output domain bound to DNA, we observe how the NarL family of two-component response regulators can bind DNA. DNA recognition...

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Bibliographic Details
Published in:	Nature Structural Biology Vol. 9; no. 10; pp. 771 - 778
Main Authors:	Maris, Ann E., Sawaya, Michael R., Kaczor-Grzeskowiak, Maria, Jarvis, Michael R., Bearson, Shawn M.D., Kopka, Mary L., Schröder, Imke, Gunsalus, Robert P., Dickerson, Richard E.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2002 Nature Publishing Group
Subjects:	Bacterial Proteins - chemistry Bacterial Proteins - metabolism Biochemistry Biological Microscopy Biomedical and Life Sciences Cloning, Molecular Crystallography, X-Ray Deoxyribonucleic acid Dimerization DNA DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism E coli Escherichia coli Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Life Sciences Membrane Biology Nucleic Acid Conformation Promoter Regions, Genetic Protein Binding Protein Conformation Protein Structure Protein Structure, Secondary Recombinant Proteins - chemistry Structure-Activity Relationship
ISSN:	1072-8368, 1545-9993, 1545-9985
Online Access:	Get full text
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