Association Between Respiratory Syncytial Virus-Associated Acute Lower Respiratory Infection in Early Life and Recurrent Wheeze and Asthma in Later Childhood

Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years. We estimated the strength of associatio...

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Bibliographic Details
Published in:The Journal of infectious diseases Vol. 222; no. Suppl 7; p. S628
Main Authors: Shi, Ting, Ooi, Yujing, Zaw, Ei Mon, Utjesanovic, Natasa, Campbell, Harry, Cunningham, Steve, Bont, Louis, Nair, Harish
Format: Journal Article
Language:English
Published: United States 07.10.2020
Subjects:
Asthma - complications
Child
Child, Preschool
Humans
Recurrence
Respiratory Sounds - etiology
Respiratory Syncytial Virus Infections - complications
Respiratory Syncytial Virus, Human
Respiratory Tract Infections - complications
Risk Factors
asthma
recurrent wheeze
children
respiratory syncytial virus
ISSN:1537-6613, 1537-6613
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Summary:Recurrent wheeze and asthma in childhood are commons causes of chronic respiratory morbidity globally. We aimed to explore the association between respiratory syncytial virus (RSV) infection in early life and subsequent respiratory sequelae up to age 12 years. We estimated the strength of association by 3 control groups and 3 follow-up age groups, with data from studies published between January 1995 and May 2018. We also estimated associations by diagnostic criteria, age at infection, and high-risk population. Overall, we included 41 studies. A statistically significant association was observed between early life RSV infection and subsequent childhood recurrent wheeze, in comparison to those who were healthy or those without respiratory symptoms: OR 3.05 (95% confidence interval [CI], 2.50-3.71) for 0 to <36 months follow-up age; OR 2.60 (95% CI, 1.67-4.04) for 36-72 months; and OR 2.14 (95% CI, 1.33-3.45) for 73-144 months. For the subsequent development of asthma, a statistically significant association was observed only in relation to those aged 73-144 months at follow-up: OR 2.95 (95% CI, 1.96-4.46). Further studies using standardized definitions and from diverse settings are needed to elucidate the role of confounders and provide more robust estimates.
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ISSN:1537-6613
1537-6613
DOI:10.1093/infdis/jiz311