“Energetic” Cancer Stem Cells (e-CSCs): A New Hyper-Metabolic and Proliferative Tumor Cell Phenotype, Driven by Mitochondrial Energy

Here, we provide the necessary evidence that mitochondrial metabolism drives the anchorage-independent proliferation of CSCs. Two human breast cancer cell lines, MCF7 [ER(+)] and MDA-MB-468 (triple-negative), were used as model systems. To directly address the issue of metabolic heterogeneity in can...

Full description

Bibliographic Details

Published in:	Frontiers in oncology Vol. 8; p. 677
Main Authors:	Fiorillo, Marco, Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 05.02.2019
Subjects:	cancer stem-like cells (CSCs) Diphenyleneiodonium (DPI) glycolysis metabolism mitochondrial OXPHOS Oncology Ribociclib Ribociclib mitochondrial OXPHOS cancer stem-like cells (CSCs) metabolism Diphenyleneiodonium (DPI) glycolysis
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!