Current Concepts in Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

The t(9;22)(q34;q11) or Philadelphia chromosome creates a BCR-ABL1 fusion gene encoding for a chimeric BCR-ABL1 protein. It is present in 3-4% of pediatric acute lymphoblastic leukemia (Ph(+) ALL), and about 25% of adult ALL cases. Prior to the advent of tyrosine kinase inhibitors (TKI), Ph(+) ALL w...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 4; p. 54
Main Authors:	Bernt, Kathrin M., Hunger, Stephen P.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 01.01.2014
Subjects:	Acute Lymphoblastic Leukemia BCR-ABL1 chemotherapy Hematopoietic Stem Cell Transplantation Oncology Tyrosine Kinase Inhibition hematopoietic stem-cell transplantation tyrosine kinase inhibition acute lymphoblastic leukemia chemotherapy BCR–ABL1
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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