Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Most cancers have lost a critical DNA damage response (DDR) pathway during tumor evolution. These alterations provide a useful explanation for the initial sensitivity of tumors to DNA-targeting chemotherapy. A striking example is dysfunctional homology-directed repair (HDR), e.g., due to inactivatin...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 10; p. 670
Main Authors:	Liptay, Martin, Barbosa, Joana S., Rottenberg, Sven
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 05.05.2020
Subjects:	chemotherapy DNA damage response DNA damage tolerance DNA replication drug resistance Oncology replication fork BRCA1/2 DNA damage tolerance DNA replication DNA damage response PARP inhibitors replication fork drug resistance chemotherapy
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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