Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease
Background PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. Objectives To identify gut dysbiosis in PD across countri...
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| Vydané v: | Movement disorders Ročník 35; číslo 9; s. 1626 - 1635 |
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| Hlavní autori: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Hoboken, USA
John Wiley & Sons, Inc
01.09.2020
Wiley Subscription Services, Inc |
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| ISSN: | 0885-3185, 1531-8257, 1531-8257 |
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| Abstract | Background
PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.
Objectives
To identify gut dysbiosis in PD across countries.
Methods
We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta‐analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.
Results
After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol‐O‐methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol‐O‐methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta‐analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short‐chain fatty acid metabolisms in our dataset.
Conclusions
We report that intestinal mucin layer‐degrading Akkermansia is increased and that short‐chain fatty acid–producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society |
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| AbstractList | BackgroundPD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.ObjectivesTo identify gut dysbiosis in PD across countries.MethodsWe performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta‐analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.ResultsAfter adjusting for confounding factors (body mass index, constipation, sex, age, and catechol‐O‐methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol‐O‐methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta‐analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short‐chain fatty acid metabolisms in our dataset.ConclusionsWe report that intestinal mucin layer‐degrading Akkermansia is increased and that short‐chain fatty acid–producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society Background PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. Objectives To identify gut dysbiosis in PD across countries. Methods We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta‐analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method. Results After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol‐O‐methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol‐O‐methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta‐analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short‐chain fatty acid metabolisms in our dataset. Conclusions We report that intestinal mucin layer‐degrading Akkermansia is increased and that short‐chain fatty acid–producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society PD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.BACKGROUNDPD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD.To identify gut dysbiosis in PD across countries.OBJECTIVESTo identify gut dysbiosis in PD across countries.We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta-analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.METHODSWe performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta-analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method.After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol-O-methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol-O-methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta-analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short-chain fatty acid metabolisms in our dataset.RESULTSAfter adjusting for confounding factors (body mass index, constipation, sex, age, and catechol-O-methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol-O-methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta-analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short-chain fatty acid metabolisms in our dataset.We report that intestinal mucin layer-degrading Akkermansia is increased and that short-chain fatty acid-producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society.CONCLUSIONSWe report that intestinal mucin layer-degrading Akkermansia is increased and that short-chain fatty acid-producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society. PD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. To identify gut dysbiosis in PD across countries. We performed 16S ribosomal RNA gene sequencing analysis of gut microbiota in 223 patients with PD and 137 controls, and meta-analyzed gut dysbiosis by combining our dataset with four previously reported data sets from the United States, Finland, Russia, and Germany. We excluded uncommon taxa from our analyses. For pathway analysis, we developed the Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis method. After adjusting for confounding factors (body mass index, constipation, sex, age, and catechol-O-methyl transferase inhibitor), genera Akkermansia and Catabacter, as well as families Akkermansiaceae, were increased, whereas genera Roseburia, Faecalibacterium, and Lachnospiraceae ND3007 group were decreased in PD. Catechol-O-methyl transferase inhibitor intake markedly increased family Lactobacillaceae. Inspection of these bacteria in 12 datasets that were not included in the meta-analysis revealed that increased genus Akkermansia and decreased genera Roseburia and Faecalibacterium were frequently observed across countries. Kyoto Encyclopedia of Genes and Genomes orthology set enrichment analysis revealed changes in short-chain fatty acid metabolisms in our dataset. We report that intestinal mucin layer-degrading Akkermansia is increased and that short-chain fatty acid-producing Roseburia and Faecalibacterium are decreased in PD across countries. © 2020 International Parkinson and Movement Disorder Society. |
| Author | Shimamura, Teppei Hamaguchi, Tomonari Katsuno, Masahisa Hirayama, Masaaki Ito, Mikako Ishida, Tomohiro Maeda, Tetsuya Kurokawa, Ken Kashihara, Kenichi Ohno, Kinji Nishiwaki, Hiroshi Tsuboi, Yoshio Mori, Hiroshi Ueyama, Jun |
| Author_xml | – sequence: 1 givenname: Hiroshi surname: Nishiwaki fullname: Nishiwaki, Hiroshi organization: Nagoya University Graduate School of Medicine – sequence: 2 givenname: Mikako surname: Ito fullname: Ito, Mikako organization: Nagoya University Graduate School of Medicine – sequence: 3 givenname: Tomohiro surname: Ishida fullname: Ishida, Tomohiro organization: Nagoya University Graduate School of Medicine – sequence: 4 givenname: Tomonari surname: Hamaguchi fullname: Hamaguchi, Tomonari organization: Nagoya University Graduate School of Medicine – sequence: 5 givenname: Tetsuya surname: Maeda fullname: Maeda, Tetsuya organization: Iwate Medical University – sequence: 6 givenname: Kenichi surname: Kashihara fullname: Kashihara, Kenichi organization: Okayama Kyokuto Hospital – sequence: 7 givenname: Yoshio surname: Tsuboi fullname: Tsuboi, Yoshio organization: Fukuoka University – sequence: 8 givenname: Jun surname: Ueyama fullname: Ueyama, Jun organization: Nagoya University Graduate School of Medicine – sequence: 9 givenname: Teppei surname: Shimamura fullname: Shimamura, Teppei organization: Nagoya University Graduate School of Medicine – sequence: 10 givenname: Hiroshi surname: Mori fullname: Mori, Hiroshi organization: National Institute of Genetics – sequence: 11 givenname: Ken surname: Kurokawa fullname: Kurokawa, Ken organization: National Institute of Genetics – sequence: 12 givenname: Masahisa surname: Katsuno fullname: Katsuno, Masahisa organization: Nagoya University Graduate School of Medicine – sequence: 13 givenname: Masaaki surname: Hirayama fullname: Hirayama, Masaaki email: hirasan@met.nagoya-u.ac.jp organization: Nagoya University Graduate School of Medicine – sequence: 14 givenname: Kinji surname: Ohno fullname: Ohno, Kinji email: ohnok@med.nagoya-u.ac.jp organization: Nagoya University Graduate School of Medicine |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32557853$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.ab.2019.113508 10.1212/WNL.0000000000002919 10.1002/mds.26942 10.1002/mds.27581 10.1038/srep00898 10.5534/wjmh.190009 10.1093/brain/awt037 10.1007/s10517-017-3700-7 10.1111/jgh.14144 10.1097/MIB.0000000000000735 10.1016/j.parkreldis.2019.06.003 10.1093/ibd/izy190 10.1128/JVI.01399-16 10.1002/mds.26069 10.1016/j.cell.2018.08.049 10.1073/pnas.0804812105 10.1038/srep30891 10.1186/s40168-019-0713-7 10.1073/pnas.0506580102 10.1016/j.parkreldis.2016.08.019 10.1186/s13073-017-0428-y 10.1016/S0140-6736(14)61393-3 10.1371/journal.pone.0142164 10.1038/nature09944 10.1002/mds.27105 10.1093/nar/gky448 10.1001/jamaneurol.2018.0605 10.1186/s13024-018-0257-5 10.1016/j.cell.2016.10.043 10.1111/j.1365-2990.2006.00727.x 10.1002/ana.24448 10.1016/j.parkreldis.2018.05.007 10.3389/fnmol.2019.00171 10.1126/scitranslmed.aar5280 10.1093/sysbio/syy054 10.1038/nrmicro3344 10.1007/s11427-016-9001-4 10.1371/journal.pone.0217050 10.1017/jns.2017.52 10.3748/wjg.v17.i12.1519 10.1093/bioinformatics/btx701 10.1016/j.nbd.2011.10.014 10.3402/mehd.v26.27663 10.1093/nar/gkh063 10.1002/sim.1186 10.3389/fneur.2019.01155 10.1136/gutjnl-2013-304833 10.1111/j.1442-9993.2001.01070.pp.x 10.1155/2015/476041 10.1136/gutjnl-2017-315666 10.1073/pnas.1514475112 10.1002/mds.25736 10.1099/ijs.0.02873-0 10.14802/jmd.18067 10.1038/nbt.2676 10.1002/mds.26424 10.1016/j.bbr.2015.05.052 10.1002/ana.20904 10.1186/s40478-015-0196-0 10.1002/ana.24531 10.1016/j.bbi.2018.02.016 10.1126/science.aat5236 10.1016/j.ebiom.2019.05.064 10.1016/j.neulet.2005.11.012 10.1002/mds.25020 10.1371/journal.pone.0028032 10.1002/mds.26307 10.1038/s41598-019-45311-y 10.1016/j.cell.2016.05.041 10.1053/j.gastro.2015.10.005 10.1016/S0197-4580(02)00065-9 10.1016/j.mib.2013.06.003 10.3233/NHA-170030 10.1212/WNL.0000000000003961 10.1016/j.cell.2016.11.018 10.3233/JPD-191711 10.1016/j.neuroscience.2013.04.037 10.1016/j.brainres.2010.07.041 |
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| Notes | This study was supported by Grants‐in‐Aid from the Japan Society for the Promotion of Science (JP17K07094 and JP19K16516); the Ministry of Health, Labour and Welfare of Japan (H29‐Nanchi‐Ippan‐030); the Japan Agency for Medical Research and Development (JJP19gm1010002, JP19ek0109230, JP19ek0109281, and JP19bm0804005), the National Center of Neurology and Psychiatry (29‐4), The Smoking Research Foundation, and the Hori Sciences and Arts Foundation. Funding agencies had no role in the management, analysis, or interpretation of the data nor were they involved in preparation, review, or approval of the manuscript. The funders were also not involved in the decision to submit the manuscript for publication. Full financial disclosures and author roles may be found in the online version of this article. Nothing to report. Relevant conflicts of interest/financial disclosures Funding agencies ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 |
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| References | 2015; 78 2018; 361 2017; 6 2006; 32 2019; 10 2017; 88 2019; 12 2015; 386 2015; 30 2019; 14 2016; 32 2013; 246 2008; 105 2014; 29 2014; 63 2011; 17 2017; 9 2011; 473 2018; 46 2018; 175 2004; 32 2006; 60 2015; 291 2003; 327 2018; 4 2013; 16 2016; 90 2019; 65 2005; 102 2019; 68 2017; 32 2019; 25 2016; 87 2018; 70 1667; 2017 2017; 162 2012; 27 2018; 34 2018; 33 2018; 75 2014; 12 2016; 150 2019; 7 2019; 9 2017; 60 2015; 3 2019; 34 2015; 10 2020; 589 2016; 167 2020; 38 2006; 396 2016; 165 2001; 26 2011; 6 2010; 1354 2004; 54 2016; 6 2015; 26 2012; 2 2019; 44 2015; 112 2013; 31 2003; 24 2002; 249 2015; 2015 2013; 136 2012; 46 2018; 10 2018; 53 2016; 22 2018; 13 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_68_1 e_1_2_8_3_1 e_1_2_8_81_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_66_1 e_1_2_8_22_1 e_1_2_8_45_1 e_1_2_8_64_1 e_1_2_8_62_1 e_1_2_8_41_1 e_1_2_8_60_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_59_1 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_57_1 e_1_2_8_70_1 Tan AH (e_1_2_8_44_1) 2018; 33 e_1_2_8_32_1 e_1_2_8_55_1 e_1_2_8_78_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_76_1 e_1_2_8_51_1 e_1_2_8_74_1 e_1_2_8_30_1 e_1_2_8_72_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 e_1_2_8_27_1 e_1_2_8_48_1 e_1_2_8_69_1 Hopfner F (e_1_2_8_39_1) 1667; 2017 e_1_2_8_2_1 e_1_2_8_80_1 e_1_2_8_4_1 e_1_2_8_6_1 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_67_1 e_1_2_8_23_1 e_1_2_8_65_1 e_1_2_8_63_1 e_1_2_8_40_1 e_1_2_8_61_1 e_1_2_8_82_1 e_1_2_8_18_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_58_1 e_1_2_8_79_1 Braak H (e_1_2_8_9_1) 2002; 249 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_56_1 e_1_2_8_77_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_54_1 e_1_2_8_75_1 e_1_2_8_52_1 e_1_2_8_73_1 e_1_2_8_50_1 e_1_2_8_71_1 |
| References_xml | – volume: 12 start-page: 171 year: 2019 article-title: Gut microbiota differs between Parkinson's disease patients and healthy controls in Northeast China publication-title: Front Mol Neurosci – volume: 249 issue: Suppl. 3 year: 2002 article-title: Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) publication-title: J Neurol – volume: 291 start-page: 306 year: 2015 end-page: 314 article-title: Beneficial effects of sodium butyrate in 6‐OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity publication-title: Behav Brain Res – volume: 246 start-page: 382 year: 2013 end-page: 390 article-title: Sodium butyrate improves locomotor impairment and early mortality in a rotenone‐induced Drosophila model of Parkinson's disease publication-title: Neuroscience – volume: 7 start-page: 98 year: 2019 article-title: Dietary fructose‐induced gut dysbiosis promotes mouse hippocampal neuroinflammation: a benefit of short‐chain fatty acids publication-title: Microbiome – volume: 396 start-page: 67 year: 2006 end-page: 72 article-title: Gastric alpha‐synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease‐related brain pathology publication-title: Neurosci Lett – volume: 78 start-page: 522 year: 2015 end-page: 529 article-title: Vagotomy and subsequent risk of Parkinson's disease publication-title: Ann Neurol – volume: 60 start-page: 197 year: 2006 end-page: 203 article-title: Pesticide exposure and risk for Parkinson's disease publication-title: Ann Neurol – volume: 14 year: 2019 article-title: Scalable methods for analyzing and visualizing phylogenetic placement of metagenomic samples publication-title: PLoS One – volume: 12 start-page: 661 year: 2014 end-page: 672 article-title: The gut microbiota, bacterial metabolites and colorectal cancer publication-title: Nat Rev Microbiol – volume: 32 start-page: 284 year: 2006 end-page: 295 article-title: Alpha‐synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects publication-title: Neuropathol Appl Neurobiol – volume: 2 start-page: 898 year: 2012 article-title: Environmental toxins trigger PD‐like progression via increased alpha‐synuclein release from enteric neurons in mice publication-title: Sci Rep – volume: 70 start-page: 194 year: 2018 end-page: 202 article-title: Alteration of the fecal microbiota in Chinese patients with Parkinson's disease publication-title: Brain Behav Immun – volume: 44 start-page: 691 year: 2019 end-page: 707 article-title: Gut microbiota in Parkinson's disease: temporal stability and relations to disease progression publication-title: EBioMedicine – volume: 9 start-page: 8837 year: 2019 article-title: Bidirectional regulatory potentials of short‐chain fatty acids and their G‐protein‐coupled receptors in autoimmune neuroinflammation publication-title: Sci Rep – volume: 162 start-page: 734 year: 2017 end-page: 737 article-title: Analysis of gut microbiota in patients with Parkinson's disease publication-title: Bull Exp Biol Med – volume: 589 start-page: 113508 year: 2020 article-title: Freeze‐drying enables homogeneous and stable sample preparation for determination of fecal short‐chain fatty acids publication-title: Anal Biochem – volume: 68 start-page: 365 year: 2019 end-page: 369 article-title: EPA‐ng: massively parallel evolutionary placement of genetic sequences publication-title: Syst Biol – volume: 10 year: 2015 article-title: Intestinal dysbiosis and lowered serum lipopolysaccharide‐binding protein in Parkinson's disease publication-title: PLoS One – volume: 6 start-page: 30891 year: 2016 article-title: Exposure to bacterial endotoxin generates a distinct strain of alpha‐synuclein fibril publication-title: Sci Rep – volume: 30 start-page: 1591 year: 2015 end-page: 1601 article-title: MDS clinical diagnostic criteria for Parkinson's disease publication-title: Mov Disord – volume: 34 start-page: 396 year: 2019 end-page: 405 article-title: Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism publication-title: Mov Disord – volume: 26 start-page: 27663 year: 2015 article-title: Analysis of composition of microbiomes: a novel method for studying microbial composition publication-title: Microb Ecol Health Dis – volume: 3 start-page: 12 year: 2015 article-title: Structural alterations of the intestinal epithelial barrier in Parkinson's disease publication-title: Acta Neuropathol Commun – volume: 32 start-page: 66 year: 2016 end-page: 72 article-title: Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age‐matched controls publication-title: Parkinsonism Relat Disord – volume: 102 start-page: 15545 year: 2005 end-page: 15550 article-title: Gene set enrichment analysis: a knowledge‐based approach for interpreting genome‐wide expression profiles publication-title: Proc Natl Acad Sci U S A – volume: 27 start-page: 716 year: 2012 end-page: 719 article-title: Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's disease? Evidence from 3 cases publication-title: Mov Disord – volume: 150 start-page: 367 year: 2016 end-page: 379.e1 article-title: Relationship between microbiota of the colonic mucosa vs feces and symptoms, colonic transit, and methane production in female patients with chronic constipation publication-title: Gastroenterology – volume: 90 start-page: 9182 year: 2016 end-page: 9193 article-title: Neuroinvasion of alpha‐synuclein prionoids after intraperitoneal and intraglossal inoculation publication-title: J Virol – volume: 30 start-page: 1351 year: 2015 end-page: 1360 article-title: Colonic bacterial composition in Parkinson's disease publication-title: Mov Disord – volume: 16 start-page: 255 year: 2013 end-page: 261 article-title: and human intestinal health publication-title: Curr Opin Microbiol – volume: 87 start-page: 505 year: 2016 end-page: 512 article-title: The diagnostic discrimination of cutaneous alpha‐synuclein deposition in Parkinson disease publication-title: Neurology – volume: 32 start-page: D277 issue: Database issue year: 2004 end-page: D280 article-title: The KEGG resource for deciphering the genome publication-title: Nucleic Acids Res – volume: 386 start-page: 896 year: 2015 end-page: 912 article-title: Parkinson's disease publication-title: Lancet – volume: 10 year: 2018 article-title: The vermiform appendix impacts the risk of developing Parkinson's disease publication-title: Sci Transl Med – volume: 68 start-page: 18 year: 2019 end-page: 24 article-title: Inflammatory bowel disease increases the risk of Parkinson's disease: a Danish nationwide cohort study 1977–2014 publication-title: Gut – volume: 105 start-page: 16731 year: 2008 end-page: 16736 article-title: Faecalibacterium prausnitzii is an anti‐inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients publication-title: Proc Natl Acad Sci U S A – volume: 32 start-page: 739 year: 2017 end-page: 749 article-title: Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome publication-title: Mov Disord – volume: 60 start-page: 1223 year: 2017 end-page: 1233 article-title: Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features publication-title: Sci China Life Sci – volume: 473 start-page: 174 year: 2011 end-page: 180 article-title: Enterotypes of the human gut microbiome publication-title: Nature – volume: 167 start-page: 1469 year: 2016 end-page: 1480.e12 article-title: Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson's disease publication-title: Cell – volume: 26 start-page: 32 year: 2001 end-page: 46 article-title: A new method for non‐parametric multivariate analysis of variance publication-title: Austral Ecol – volume: 17 start-page: 1519 year: 2011 end-page: 1528 article-title: Potential beneficial effects of butyrate in intestinal and extraintestinal diseases publication-title: World J Gastroenterol – volume: 29 start-page: 999 year: 2014 end-page: 1009 article-title: Progression of intestinal permeability changes and alpha‐synuclein expression in a mouse model of Parkinson's disease publication-title: Mov Disord – volume: 33 start-page: 88 year: 2018 end-page: 98 article-title: The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder publication-title: Mov Disord – volume: 9 start-page: S297 issue: s2 year: 2019 end-page: S312 article-title: Increasing comparability and utility of gut microbiome studies in Parkinson's disease: a systematic review publication-title: J Parkinsons Dis – volume: 88 start-page: 1996 year: 2017 end-page: 2002 article-title: Vagotomy and Parkinson disease: a Swedish register‐based matched‐cohort study publication-title: Neurology – volume: 12 start-page: 67 year: 2019 end-page: 83 article-title: Altered gut microbiome and intestinal pathology in Parkinson's disease publication-title: J Mov Disord – volume: 22 start-page: 1049 year: 2016 end-page: 1055 article-title: Association between Parkinson's disease and inflammatory bowel disease: a nationwide taiwanese retrospective cohort study publication-title: Inflamm Bowel Dis – volume: 65 start-page: 124 year: 2019 end-page: 130 article-title: Dysbiosis of gut microbiota in a selected population of Parkinson's patients publication-title: Parkinsonism Relat Disord – volume: 34 start-page: 1053 year: 2018 end-page: 1055 article-title: Efficient comparative phylogenetics on large trees publication-title: Bioinformatics – volume: 63 start-page: 1275 year: 2014 end-page: 1283 article-title: A decrease of the butyrate‐producing species and defines dysbiosis in patients with ulcerative colitis publication-title: Gut – volume: 361 year: 2018 article-title: A gut‐brain neural circuit for nutrient sensory transduction publication-title: Science – volume: 24 start-page: 197 year: 2003 end-page: 211 article-title: Staging of brain pathology related to sporadic Parkinson's disease publication-title: Neurobiol Aging – volume: 54 start-page: 1469 issue: Pt. 5 year: 2004 end-page: 1476 article-title: Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin‐degrading bacterium publication-title: Int J Syst Evol Microbiol – volume: 167 start-page: 1339 year: 2016 end-page: 1353.e21 article-title: A dietary fiber‐deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility publication-title: Cell – volume: 78 start-page: 1011 year: 2015 end-page: 1012 article-title: Does vagotomy reduce the risk of Parkinson's disease? publication-title: Ann Neurol – volume: 46 start-page: W200 issue: W1 year: 2018 end-page: W204 article-title: HMMER web server: 2018 update publication-title: Nucleic Acids Res – volume: 38 start-page: 48 year: 2020 end-page: 60 article-title: Sex differences in gut microbiota publication-title: World J Mens Health – volume: 33 start-page: S783 year: 2018 end-page: S784 article-title: Unveiling the function of altered gut microbiota composition in Parkinson's disease publication-title: Mov Disord – volume: 31 start-page: 814 year: 2013 end-page: 821 article-title: Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences publication-title: Nat Biotechnol – volume: 165 start-page: 1332 year: 2016 end-page: 1345 article-title: From dietary fiber to host physiology: short‐chain fatty acids as key bacterial metabolites publication-title: Cell – volume: 136 start-page: 1128 issue: Pt. 4 year: 2013 end-page: 1138 article-title: Prion‐like spreading of pathological alpha‐synuclein in brain publication-title: Brain – volume: 9 start-page: 39 year: 2017 article-title: Functional implications of microbial and viral gut metagenome changes in early stage L‐DOPA‐naive Parkinson's disease patients publication-title: Genome Med – volume: 53 start-page: 82 year: 2018 end-page: 88 article-title: Gut microbiota in patients with Parkinson's disease in southern China publication-title: Parkinsonism Relat Disord – volume: 327 start-page: 557 year: 2003 end-page: 560 article-title: Measuring inconsistency in meta‐analyses publication-title: BMJ – volume: 13 start-page: 21 year: 2018 article-title: Inoculation of alpha‐synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body‐like aggregates in the brainstem via the vagus nerve publication-title: Mol Neurodegener – volume: 75 start-page: 939 year: 2018 end-page: 946 article-title: Anti‐tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease publication-title: JAMA Neurol – volume: 6 year: 2011 article-title: Increased intestinal permeability correlates with sigmoid mucosa alpha‐synuclein staining and endotoxin exposure markers in early Parkinson's disease publication-title: PLoS One – volume: 4 start-page: 267 year: 2018 end-page: 285 article-title: Gut microbiome and aging: physiological and mechanistic insights publication-title: Nutr Healthy Aging – volume: 33 start-page: 1751 year: 2018 end-page: 1760 article-title: Insights into which alleviates experimental colitis pathology by inducing anti‐inflammatory responses publication-title: J Gastroenterol Hepatol – volume: 112 start-page: E5308 year: 2015 end-page: E5317 article-title: Evidence for alpha‐synuclein prions causing multiple system atrophy in humans with parkinsonism publication-title: Proc Natl Acad Sci U S A – volume: 10 start-page: 1155 year: 2019 article-title: The role of the gut microbiota in the pathogenesis of Parkinson's disease publication-title: Front Neurol – volume: 6 year: 2017 article-title: Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial publication-title: J Nutr Sci – volume: 2017 start-page: 41 year: 1667 end-page: 45 article-title: Gut microbiota in Parkinson disease in a northern German cohort publication-title: Brain Res – volume: 30 start-page: 350 year: 2015 end-page: 358 article-title: Gut microbiota are related to Parkinson's disease and clinical phenotype publication-title: Mov Disord – volume: 46 start-page: 559 year: 2012 end-page: 564 article-title: Pathological correlates of gastrointestinal dysfunction in Parkinson's disease publication-title: Neurobiol Dis – volume: 2015 start-page: 476041 year: 2015 article-title: Gastrointestinal biopsies for the diagnosis of alpha‐synuclein pathology in Parkinson's disease publication-title: Gastroenterol Res Pract – volume: 175 start-page: 665 year: 2018 end-page: 678.e23 article-title: A neural circuit for gut‐induced reward publication-title: Cell – volume: 25 start-page: 111 year: 2019 end-page: 123 article-title: Inflammatory bowel disease and Parkinson's disease: a nationwide Swedish cohort study publication-title: Inflamm Bowel Dis – volume: 1354 start-page: 172 year: 2010 end-page: 178 article-title: Protection of dopaminergic cells from MPP+‐mediated toxicity by histone deacetylase inhibition publication-title: Brain Res – ident: e_1_2_8_53_1 doi: 10.1016/j.ab.2019.113508 – ident: e_1_2_8_5_1 doi: 10.1212/WNL.0000000000002919 – ident: e_1_2_8_36_1 doi: 10.1002/mds.26942 – ident: e_1_2_8_45_1 doi: 10.1002/mds.27581 – ident: e_1_2_8_24_1 doi: 10.1038/srep00898 – ident: e_1_2_8_62_1 doi: 10.5534/wjmh.190009 – ident: e_1_2_8_12_1 doi: 10.1093/brain/awt037 – ident: e_1_2_8_37_1 doi: 10.1007/s10517-017-3700-7 – ident: e_1_2_8_74_1 doi: 10.1111/jgh.14144 – ident: e_1_2_8_17_1 doi: 10.1097/MIB.0000000000000735 – ident: e_1_2_8_48_1 doi: 10.1016/j.parkreldis.2019.06.003 – ident: e_1_2_8_20_1 doi: 10.1093/ibd/izy190 – ident: e_1_2_8_22_1 doi: 10.1128/JVI.01399-16 – ident: e_1_2_8_33_1 doi: 10.1002/mds.26069 – volume: 33 start-page: S783 year: 2018 ident: e_1_2_8_44_1 article-title: Unveiling the function of altered gut microbiota composition in Parkinson's disease publication-title: Mov Disord – ident: e_1_2_8_26_1 doi: 10.1016/j.cell.2018.08.049 – ident: e_1_2_8_76_1 doi: 10.1073/pnas.0804812105 – ident: e_1_2_8_31_1 doi: 10.1038/srep30891 – ident: e_1_2_8_67_1 doi: 10.1186/s40168-019-0713-7 – ident: e_1_2_8_60_1 doi: 10.1073/pnas.0506580102 – ident: e_1_2_8_35_1 doi: 10.1016/j.parkreldis.2016.08.019 – ident: e_1_2_8_38_1 doi: 10.1186/s13073-017-0428-y – ident: e_1_2_8_10_1 doi: 10.1016/S0140-6736(14)61393-3 – ident: e_1_2_8_28_1 doi: 10.1371/journal.pone.0142164 – ident: e_1_2_8_51_1 doi: 10.1038/nature09944 – volume: 2017 start-page: 41 year: 1667 ident: e_1_2_8_39_1 article-title: Gut microbiota in Parkinson disease in a northern German cohort publication-title: Brain Res – ident: e_1_2_8_43_1 doi: 10.1002/mds.27105 – ident: e_1_2_8_56_1 doi: 10.1093/nar/gky448 – ident: e_1_2_8_18_1 doi: 10.1001/jamaneurol.2018.0605 – ident: e_1_2_8_23_1 doi: 10.1186/s13024-018-0257-5 – ident: e_1_2_8_71_1 doi: 10.1016/j.cell.2016.10.043 – ident: e_1_2_8_2_1 doi: 10.1111/j.1365-2990.2006.00727.x – ident: e_1_2_8_14_1 doi: 10.1002/ana.24448 – ident: e_1_2_8_42_1 doi: 10.1016/j.parkreldis.2018.05.007 – ident: e_1_2_8_47_1 doi: 10.3389/fnmol.2019.00171 – ident: e_1_2_8_21_1 doi: 10.1126/scitranslmed.aar5280 – ident: e_1_2_8_57_1 doi: 10.1093/sysbio/syy054 – ident: e_1_2_8_78_1 doi: 10.1038/nrmicro3344 – ident: e_1_2_8_40_1 doi: 10.1007/s11427-016-9001-4 – ident: e_1_2_8_58_1 doi: 10.1371/journal.pone.0217050 – volume: 249 issue: 3 year: 2002 ident: e_1_2_8_9_1 article-title: Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) publication-title: J Neurol – ident: e_1_2_8_69_1 doi: 10.1017/jns.2017.52 – ident: e_1_2_8_77_1 doi: 10.3748/wjg.v17.i12.1519 – ident: e_1_2_8_59_1 doi: 10.1093/bioinformatics/btx701 – ident: e_1_2_8_6_1 doi: 10.1016/j.nbd.2011.10.014 – ident: e_1_2_8_65_1 doi: 10.3402/mehd.v26.27663 – ident: e_1_2_8_54_1 doi: 10.1093/nar/gkh063 – ident: e_1_2_8_61_1 doi: 10.1002/sim.1186 – ident: e_1_2_8_49_1 doi: 10.3389/fneur.2019.01155 – ident: e_1_2_8_75_1 doi: 10.1136/gutjnl-2013-304833 – ident: e_1_2_8_64_1 doi: 10.1111/j.1442-9993.2001.01070.pp.x – ident: e_1_2_8_11_1 doi: 10.1155/2015/476041 – ident: e_1_2_8_19_1 doi: 10.1136/gutjnl-2017-315666 – ident: e_1_2_8_13_1 doi: 10.1073/pnas.1514475112 – ident: e_1_2_8_30_1 doi: 10.1002/mds.25736 – ident: e_1_2_8_70_1 doi: 10.1099/ijs.0.02873-0 – ident: e_1_2_8_4_1 doi: 10.14802/jmd.18067 – ident: e_1_2_8_55_1 doi: 10.1038/nbt.2676 – ident: e_1_2_8_52_1 doi: 10.1002/mds.26424 – ident: e_1_2_8_82_1 doi: 10.1016/j.bbr.2015.05.052 – ident: e_1_2_8_72_1 doi: 10.1002/ana.20904 – ident: e_1_2_8_29_1 doi: 10.1186/s40478-015-0196-0 – ident: e_1_2_8_16_1 doi: 10.1002/ana.24531 – ident: e_1_2_8_41_1 doi: 10.1016/j.bbi.2018.02.016 – ident: e_1_2_8_25_1 doi: 10.1126/science.aat5236 – ident: e_1_2_8_46_1 doi: 10.1016/j.ebiom.2019.05.064 – ident: e_1_2_8_7_1 doi: 10.1016/j.neulet.2005.11.012 – ident: e_1_2_8_8_1 doi: 10.1002/mds.25020 – ident: e_1_2_8_27_1 doi: 10.1371/journal.pone.0028032 – ident: e_1_2_8_34_1 doi: 10.1002/mds.26307 – ident: e_1_2_8_66_1 doi: 10.1038/s41598-019-45311-y – ident: e_1_2_8_79_1 doi: 10.1016/j.cell.2016.05.041 – ident: e_1_2_8_68_1 doi: 10.1053/j.gastro.2015.10.005 – ident: e_1_2_8_3_1 doi: 10.1016/S0197-4580(02)00065-9 – ident: e_1_2_8_73_1 doi: 10.1016/j.mib.2013.06.003 – ident: e_1_2_8_63_1 doi: 10.3233/NHA-170030 – ident: e_1_2_8_15_1 doi: 10.1212/WNL.0000000000003961 – ident: e_1_2_8_32_1 doi: 10.1016/j.cell.2016.11.018 – ident: e_1_2_8_50_1 doi: 10.3233/JPD-191711 – ident: e_1_2_8_81_1 doi: 10.1016/j.neuroscience.2013.04.037 – ident: e_1_2_8_80_1 doi: 10.1016/j.brainres.2010.07.041 |
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PD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut... PD may begin with the intestinal accumulation of α-synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut microbiota... BackgroundPD may begin with the intestinal accumulation of α‐synuclein fibrils, which can be causally associated with gut dysbiosis. The variability of gut... |
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| SubjectTerms | Body mass index Catechol Catechol O-Methyltransferase Confounding (Statistics) confounding factors Constipation Digestive system Dysbacteriosis Dysbiosis Faecalibacterium Fatty acids Feces Fibrils Finland Gastrointestinal Microbiome Gastrointestinal tract Genomes Germany gut microbiota Humans Intestinal microflora Intestine Meta-analysis Microbiota Movement disorders Mucin Neurodegenerative diseases Orthology Parkinson Disease Parkinson's disease pathway analysis rRNA 16S Sequence analysis Synuclein |
| Title | Meta‐Analysis of Gut Dysbiosis in Parkinson's Disease |
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