Prevalence of nonfounder BRCA1/2 mutations in Ashkenazi Jewish patients presenting for genetic testing at a hereditary breast and ovarian cancer center

Background Genetic assessment in Ashkenazi Jewish (AJ) patients often is limited to BRCA1/2 founder mutation testing. With access to time‐efficient and cost‐efficient multigene panel testing, some advocate expanding genetic testing in this population. However, to the best of the authors’ knowledge,...

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Vydáno v:	Cancer Ročník 125; číslo 5; s. 690 - 697
Hlavní autoři:	Frey, Melissa K., Kopparam, Rohini V., Ni Zhou, Zhen, Fields, Jessica C., Buskwofie, Ama, Carlson, Ann D., Caputo, Thomas, Holcomb, Kevin, Chapman‐Davis, Eloise
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Wiley Subscription Services, Inc 01.03.2019
Témata:	Adenomatous polyposis coli Anemia Ashkenazi Jewish Ashkenazi Jewish founder mutation testing BRCA1 BRCA1 protein BRCA2 BRCA2 protein Breast cancer C protein Cancer CHK2 protein Colorectal cancer Family medical history FANCC protein Fanconi syndrome Gene sequencing Genes Genetic disorders Genetic screening Genetics Homology Medical records MSH6 protein multigene panel Mutation Oncology Ovarian cancer p53 Protein Patients Polyposis coli Polyps Population genetics Population studies Proteins multigene panel Ashkenazi Jewish BRCA1 BRCA2 Ashkenazi Jewish founder mutation testing
ISSN:	0008-543X, 1097-0142, 1097-0142
On-line přístup:	Získat plný text
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