Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

ABSTRACT Background and objective Diagnosis of idiopathic pulmonary fibrosis (IPF) is complex and its pathogenesis is poorly understood. Recent findings indicate elevated levels of proline and other amino acids in lung tissue of IPF patients which may also be of diagnostic value. Following these fin...

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Vydáno v:	Respirology (Carlton, Vic.) Ročník 24; číslo 5; s. 437 - 444
Hlavní autoři:	Gaugg, Martin Thomas, Engler, Anna, Bregy, Lukas, Nussbaumer‐Ochsner, Yvonne, Eiffert, Lara, Bruderer, Tobias, Zenobi, Renato, Sinues, Pablo, Kohler, Malcolm
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Chichester, UK John Wiley & Sons, Ltd 01.05.2019 Wiley Subscription Services, Inc
Témata:	Aged Alanine Alanine - metabolism Amino acids Amino Acids - metabolism Area Under Curve biomarkers Biomarkers - metabolism breath tests Breath Tests - methods Case-Control Studies collagen Disease Progression Exhalation Female Fibrosis Humans Hydroxyproline Hydroxyproline - metabolism idiopathic pulmonary fibrosis Idiopathic Pulmonary Fibrosis - diagnosis Idiopathic Pulmonary Fibrosis - metabolism Isoleucine Isoleucine - metabolism Leucine Leucine - metabolism Lung diseases Male Mass spectroscopy Metabolism metabolomics Middle Aged Phenylalanine Proline Pulmonary fibrosis Pyroglutamic acid ROC Curve Spectrometry, Mass, Electrospray Ionization Valine Valine - metabolism collagen idiopathic pulmonary fibrosis metabolomics biomarkers breath tests
ISSN:	1323-7799, 1440-1843, 1440-1843
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