Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment

Neuroinflammation accompanies several brain disorders, either as a secondary consequence or as a primary cause and may contribute importantly to disease pathogenesis. Neurosteroids which act as Positive Steroid Allosteric GABA-A receptor Modulators (Steroid-PAM) appear to modulate neuroinflammation...

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Bibliographic Details
Published in:	Neuroscience and biobehavioral reviews Vol. 161; p. 105668
Main Authors:	Bäckström, Torbjörn, Doverskog, Magnus, Blackburn, Thomas P., Scharschmidt, Bruce F., Felipo, Vicente
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 01.06.2024
Subjects:	Animals Astrocytes Astrocytes - drug effects Astrocytes - metabolism Cognitive disorders GABA-A receptor GABA-A Receptor Antagonists - pharmacology Humans Microglia Microglia - drug effects Microglia - metabolism Neuroinflammation Neuroinflammatory Diseases - drug therapy Neuroinflammatory Diseases - metabolism Pregnanolone - metabolism Pregnanolone - pharmacology Steroid-PAMs NO PCS Steroid-PAM AMPA KCC2 GAMSA Cl Steroid-PAMs Cognitive disorders BDL PFC TNF LPS PBC GR 3027 GABA-A NMDA TSPO NKCC1 SN GABA-AR IL BDNF THDOC Astrocytes LID MS EAE Neuroinflammation GABA-A receptor Microglia ALLO PTBR TGR5 PD ROS 3α5α20α-HHP MAO HE NK
ISSN:	0149-7634, 1873-7528, 1873-7528
Online Access:	Get full text
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