Transient inhibition of lysosomal functions potentiates nucleic acid vaccines

Nucleic acid vaccines have shown promising results in the clinic against infectious diseases and cancers. To robustly improve the vaccine efficacy and safety, we developed an approach to increase the intracellular stability of nucleic acids by transiently inhibiting lysosomal function in targeted ti...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 44; p. e2306465120
Main Authors:	Wang, Chunxi, Karlsson, Amelia, Oguin, 3rd, Thomas H, Macintyre, Andrew N, Sempowski, Gregory D, McCarthy, Kevin R, Wang, Yifei, Moody, M Anthony, Yuan, Fan
Format:	Journal Article
Language:	English
Published:	United States 31.10.2023
Subjects:	Animals Lysosomes Mice Nanoparticles Nucleic Acid-Based Vaccines Nucleic Acids Sucrose Vaccines Vaccines, DNA lysosomal function nucleic acid vaccine delivery biomimetic nanoparticles nucleic acid vaccines
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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