Transient inhibition of lysosomal functions potentiates nucleic acid vaccines

Nucleic acid vaccines have shown promising results in the clinic against infectious diseases and cancers. To robustly improve the vaccine efficacy and safety, we developed an approach to increase the intracellular stability of nucleic acids by transiently inhibiting lysosomal function in targeted ti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 120; H. 44; S. e2306465120
Hauptverfasser:	Wang, Chunxi, Karlsson, Amelia, Oguin, 3rd, Thomas H, Macintyre, Andrew N, Sempowski, Gregory D, McCarthy, Kevin R, Wang, Yifei, Moody, M Anthony, Yuan, Fan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 31.10.2023
Schlagworte:	Animals Lysosomes Mice Nanoparticles Nucleic Acid-Based Vaccines Nucleic Acids Sucrose Vaccines Vaccines, DNA lysosomal function nucleic acid vaccine delivery biomimetic nanoparticles nucleic acid vaccines
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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