The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

The transcription factor BATF is required for differentiation of certain helper T cell subsets. Haining and colleagues show that BATF crucially regulates CD8 + effector cells by coordinating a transcription factor network. The transcription factor BATF is required for the differentiation of interleu...

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Bibliographic Details
Published in:	Nature immunology Vol. 15; no. 4; pp. 373 - 383
Main Authors:	Kurachi, Makoto, Barnitz, R Anthony, Yosef, Nir, Odorizzi, Pamela M, DiIorio, Michael A, Lemieux, Madeleine E, Yates, Kathleen, Godec, Jernej, Klatt, Martin G, Regev, Aviv, Wherry, E John, Haining, W Nicholas
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.04.2014 Nature Publishing Group
Subjects:	13 13/31 38 38/15 38/23 38/77 42/44 631/250/2152/1566/1571 631/250/2152/1566/1618 64/60 Animals Antigens Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - immunology Basic-Leucine Zipper Transcription Factors - metabolism Biomedicine CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell differentiation Cell Differentiation - genetics Cell Growth Processes - genetics Cells, Cultured Cytokine receptors Down-Regulation Effector cells Granzyme B Granzymes - genetics Granzymes - metabolism Helper cells Immunology Infectious Diseases Inflammation Interferon regulatory factor 4 Interferon Regulatory Factors - metabolism Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin 17 Lymphocyte Activation - genetics Lymphocytes Lymphocytes T Male Mice Mice, Inbred C57BL Mice, Knockout Population growth Positive Regulatory Domain I-Binding Factor 1 Proto-Oncogene Proteins c-jun - metabolism T cell receptors T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Th17 Cells - immunology Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcriptional Activation - genetics γ-Interferon
ISSN:	1529-2908, 1529-2916, 1529-2916
Online Access:	Get full text
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