Glucocerebroside inhibits NADPH oxidase activation in cell-free system

We reported earlier that monocytes and macrophages from patients with type I Gaucher disease have a decreased capacity to generate superoxide anion (O2−) on stimulation with opsonized S. aureus or formyl-methionyl-leucyl-phenylalanine. In this study, various forms of the cell-free assay system were...

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Veröffentlicht in:	Biochimica et biophysica acta Jg. 1688; H. 3; S. 197 - 203
Hauptverfasser:	Moskwa, Patryk, Palicz, Anita, Paclet, Marie-Hélène, Dagher, Marie-Claire, Erdős, Melinda, Maródi, László, Ligeti, Erzsébet
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier B.V 05.04.2004
Schlagworte:	Cell-Free System Cloning, Molecular Enzyme Activation - drug effects Gaucher disease Glucocerebroside Glucosylceramides - pharmacology Humans Kinetics NADPH oxidase NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - blood NADPH Oxidases - drug effects Neutrophils - enzymology Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism Superoxides - blood Xanthine Oxidase - blood Glucocerebroside NADPH oxidase Gaucher disease
ISSN:	0925-4439, 0006-3002, 1879-260X
Online-Zugang:	Volltext
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