Molecular mechanisms of building blocks of life towards medicinal applications

Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and...

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Bibliographic Details
Published in:Keio journal of medicine Vol. 71; no. 1; p. 32
Main Author: Nureki, Osamu
Format: Journal Article
Language:English
Published: Japan 2022
Subjects:
Cryoelectron Microscopy
Crystallography, X-Ray
Humans
Membrane Proteins
Single Molecule Imaging
ISSN:1880-1293, 1880-1293
Online Access:Get more information
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Summary:Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.
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ISSN:1880-1293
1880-1293
DOI:10.2302/kjm.71-002-ABST