Molecular mechanisms of building blocks of life towards medicinal applications

Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and...

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Vydáno v:Keio journal of medicine Ročník 71; číslo 1; s. 32
Hlavní autor: Nureki, Osamu
Médium: Journal Article
Jazyk:angličtina
Vydáno: Japan 2022
Témata:
Cryoelectron Microscopy
Crystallography, X-Ray
Humans
Membrane Proteins
Single Molecule Imaging
ISSN:1880-1293, 1880-1293
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Shrnutí:Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1880-1293
1880-1293
DOI:10.2302/kjm.71-002-ABST