Molecular mechanisms of building blocks of life towards medicinal applications
Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and...
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| Vydané v: | Keio journal of medicine Ročník 71; číslo 1; s. 32 |
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| Hlavný autor: | |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
Japan
2022
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| ISSN: | 1880-1293, 1880-1293 |
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| Abstract | Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies. |
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| AbstractList | Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies. Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.Membrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies. |
| Author | Nureki, Osamu |
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| SubjectTerms | Cryoelectron Microscopy Crystallography, X-Ray Humans Membrane Proteins Single Molecule Imaging |
| Title | Molecular mechanisms of building blocks of life towards medicinal applications |
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