The orally bioavailable GSPT1/2 degrader SJ6986 exhibits in vivo efficacy in acute lymphoblastic leukemia

Advancing cure rates for high-risk acute lymphoblastic leukemia (ALL) has been limited by the lack of agents that effectively kill leukemic cells, sparing normal hematopoietic tissue. Molecular glues direct the ubiquitin ligase cellular machinery to target neosubstrates for protein degradation. We d...

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Bibliographic Details

Published in:	Blood Vol. 142; no. 7; p. 629
Main Authors:	Chang, Yunchao, Keramatnia, Fatemeh, Ghate, Pankaj S, Nishiguchi, Gisele, Gao, Qingsong, Iacobucci, Ilaria, Yang, Lei, Chepyala, Divyabharathi, Mishra, Ashutosh, High, Anthony A, Goto, Hiroaki, Akahane, Koshi, Peng, Junmin, Yang, Jun J, Fischer, Marcus, Rankovic, Zoran, Mullighan, Charles G
Format:	Journal Article
Language:	English
Published:	United States 17.08.2023
Subjects:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Child Humans Isoindoles - therapeutic use Piperidones - therapeutic use Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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