COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis

Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated whether and how SARS-CoV-2 causes hyperglycemia by infecting hepatocytes and increasing...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 21; p. e2217119120
Main Authors:	Barreto, Ester A, Cruz, Amanda S, Veras, Flavio P, Martins, Ronaldo, Bernardelli, Rafaella S, Paiva, Isadora M, Lima, Thais M, Singh, Youvika, Guimarães, Raphael C, Damasceno, Samara, Pereira, Nayara, Alves, João Manoel, Gonçalves, Tiago T, Forato, Julia, Muraro, Stéfanie P, Souza, Gabriela F, Batah, Sabrina Setembre, Proenca-Modena, José L, Mori, Marcelo A, Cunha, Fernando Q, Louzada-Junior, Paulo, Cunha, Thiago M, Nakaya, Helder I, Fabro, Alexandre, de Oliveira, Renê D R, Arruda, Eurico, Réa, Rosângela, Réa Neto, Álvaro, Fernandes da Silva, Miguel M, Leiria, Luiz Osório
Format:	Journal Article
Language:	English
Published:	United States 23.05.2023
Subjects:	Blood Glucose COVID-19 - complications Gluconeogenesis Glucose Hepatocytes Humans Hyperglycemia - complications Retrospective Studies SARS-CoV-2 liver SARS-CoV-2 glucose
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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