COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis

Occurrence of hyperglycemia upon infection is associated with worse clinical outcome in COVID-19 patients. However, it is still unknown whether SARS-CoV-2 directly triggers hyperglycemia. Herein, we interrogated whether and how SARS-CoV-2 causes hyperglycemia by infecting hepatocytes and increasing...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 120; číslo 21; s. e2217119120
Hlavní autoři:	Barreto, Ester A, Cruz, Amanda S, Veras, Flavio P, Martins, Ronaldo, Bernardelli, Rafaella S, Paiva, Isadora M, Lima, Thais M, Singh, Youvika, Guimarães, Raphael C, Damasceno, Samara, Pereira, Nayara, Alves, João Manoel, Gonçalves, Tiago T, Forato, Julia, Muraro, Stéfanie P, Souza, Gabriela F, Batah, Sabrina Setembre, Proenca-Modena, José L, Mori, Marcelo A, Cunha, Fernando Q, Louzada-Junior, Paulo, Cunha, Thiago M, Nakaya, Helder I, Fabro, Alexandre, de Oliveira, Renê D R, Arruda, Eurico, Réa, Rosângela, Réa Neto, Álvaro, Fernandes da Silva, Miguel M, Leiria, Luiz Osório
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 23.05.2023
Témata:	Blood Glucose COVID-19 - complications Gluconeogenesis Glucose Hepatocytes Humans Hyperglycemia - complications Retrospective Studies SARS-CoV-2 liver SARS-CoV-2 glucose
ISSN:	1091-6490, 1091-6490
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