Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy decidua

Leukocytes comprise approximately 30–40% of decidual stromal cells in early human pregnancy. The major leukocyte component is the uterine natural killer (uNK) cells. Despite over 20 years of research the functional role of these cells in situ remains unknown although they have been proposed to play...

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Published in:Placenta (Eastbourne) Vol. 31; pp. S87 - S92
Main Authors: Lash, G.E., Robson, S.C., Bulmer, J.N.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01.03.2010
Subjects:
Decidua
Decidua - immunology
Female
Human
Humans
Internal Medicine
Killer Cells, Natural - immunology
Neovascularization, Physiologic - immunology
Obstetrics and Gynecology
Pregnancy
Spiral artery remodeling
Trophoblast invasion
Trophoblasts - immunology
Uterine natural killer cells
Uterus - blood supply
Uterus - immunology
Human
Trophoblast invasion
Spiral artery remodeling
Decidua
Uterine natural killer cells
ISSN:0143-4004, 1532-3102, 1532-3102
Online Access:Get full text
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Summary:Leukocytes comprise approximately 30–40% of decidual stromal cells in early human pregnancy. The major leukocyte component is the uterine natural killer (uNK) cells. Despite over 20 years of research the functional role of these cells in situ remains unknown although they have been proposed to play roles in immunotolerance, regulation of trophoblast invasion and remodeling of the spiral arteries. Herein we review the functional roles of this important decidual cell type.
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ISSN:0143-4004
1532-3102
1532-3102
DOI:10.1016/j.placenta.2009.12.022