Integrative genomics and pathway analysis identified prevalent FA-BRCA pathway alterations in arsenic-associated urinary bladder carcinoma: Chronic arsenic accumulation in cancer tissues hampers the FA-BRCA pathway

Arsenic in drinking water is one of the major etiological factors in urinary bladder carcinoma (BlCa). Here, high-resolution CGH-SNP microarray analysis in arsenic accumulated BlCa tissues showed significant (p < 0.05) association of chromosomal alterations with high arsenic (≥112 ng/g) accumulat...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Jg. 112; H. 6; S. 5055 - 5065
Hauptverfasser:	Basu, Mukta, Ghosh, Sabnam, Roychowdhury, Anirban, Samadder, Sudip, Das, Pijush, Addya, Sankar, Roy, Anup, Pal, Dilip Kumar, Roychoudhury, Susanta, Ghosh, Amlan, Panda, Chinmay Kumar
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.11.2020
Schlagworte:	Arsenic bladder carcinoma chromosome translocation drinking water etiology FA-BRCA pathway genomics Ingenuity ® Pathway analysis Microarray microarray technology RAD50 regulator genes tissues tumor suppressor proteins UIMC1 RAD50 Arsenic Microarray FA-BRCA pathway UIMC1 Ingenuity ® Pathway analysis
ISSN:	0888-7543, 1089-8646, 1089-8646
Online-Zugang:	Volltext
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