Immunological Characterization of HIV and SARS-CoV-2 Coinfected Young Individuals

While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Vol. 10; no. 11; p. 3187
Main Authors: Vanetti, Claudia, Trabattoni, Daria, Stracuzzi, Marta, Amendola, Antonella, Fappani, Clara, Rubinacci, Valeria, Fenizia, Claudio, Gianolio, Laura, Biasin, Mara, Dighera, Anna, Saulle, Irma, Tanzi, Elisabetta, Zuccotti, Gianvincenzo, Clerici, Mario, Giacomet, Vania
Format: Journal Article
Language:English
Published: Basel MDPI AG 16.11.2021
MDPI
Subjects:
Antiviral agents
children
Communication
Coronaviruses
COVID-19
Cytokines
Enrollments
Gene expression
HIV
Human immunodeficiency virus
IL-10
Immune response
Immunology
Infections
Interleukin 10
Pandemics
RNA viruses
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
Vaccination
Viral infections
United States > US
Italy
ISSN:2073-4409, 2073-4409
Online Access:Get full text
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Summary:While the risk of SARS-CoV-2 infection and/or COVID-19 disease progression in the general population has been largely assessed, its impact on HIV-positive individuals remains unclear. We present clinical and immunological data collected in a cohort of HIV-infected young individuals during the first wave of COVID-19 pandemic. SARS-CoV-2 RNA, virus-specific antibodies, as well as the expression of factors involved in the anti-viral immune response were analyzed. Moreover, we set up an in vitro coinfection assay to study the mechanisms correlated to the coinfection process. Our results did not show any increased risk of severe COVID-19 in HIV-positive young individuals. In those subjects who contracted SARS-CoV-2 infection, an increase in IL-10 expression and production was observed. Furthermore, in the in vitro coinfection assay, we revealed a reduction in SARS-CoV-2 replication associated to an upregulation of IL-10. We speculate that IL-10 could play a crucial role in the course of SARS-CoV-2 infection in HIV-positive individuals. These results might help defining clinical management of HIV/SARS-CoV-2 co-infected young individuals, or putative indications for vaccination schedules in this population.
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Those authors equally contributed to the manuscript.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10113187