Collided ribosomes form a unique structural interface to induce Hel2‐driven quality control pathways

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay) and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires Hel2‐dependent uS10 ubiquitination and the RQT complex in yeast. Here, we report that Hel2‐dependent uS10 ubiquitination and...

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Vydáno v:	The EMBO journal Ročník 38; číslo 5
Hlavní autoři:	Ikeuchi, Ken, Tesina, Petr, Matsuo, Yoshitaka, Sugiyama, Takato, Cheng, Jingdong, Saeki, Yasushi, Tanaka, Keiji, Becker, Thomas, Beckmann, Roland, Inada, Toshifumi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.03.2019 Springer Nature B.V John Wiley and Sons Inc
Témata:	Cryoelectron Microscopy Decay EMBO31 EMBO32 EMBO40 mRNA mRNA turnover no‐go mRNA decay Pattern recognition Polypeptides Protein Biosynthesis Proteins Quality control Ribosomal Proteins - genetics Ribosomal Proteins - metabolism ribosome collision ribosome quality control Ribosomes Ribosomes - metabolism Ribosomes - ultrastructure RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RQT complex Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Stalling Ubiquitin Ubiquitin - metabolism Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Upstream Yeast no‐go mRNA decay ribosome quality control RQT complex ubiquitination ribosome collision
ISSN:	0261-4189, 1460-2075, 1460-2075
On-line přístup:	Získat plný text
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