Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model

Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecules sensing and responding to hypoxia in CKD remain unclear. In this study, we demonstrated in a mouse model that erythrocyte ENT1-AMPD3 is a master energy regulat...

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Vydané v:	Journal of the American Society of Nephrology Ročník 34; číslo 10; s. 1647
Hlavní autori:	Chen, Changhan, Xie, TingTing, Zhang, Yujin, Wang, Yiyan, Yu, Fang, Lin, Lizhen, Zhang, Weiru, Brown, Benjamin C, Zhang, Xin, Kellems, Rodney E, D'Alessandro, Angelo, Xia, Yang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.10.2023
Predmet:	Adenosine - metabolism AMP Deaminase - genetics AMP Deaminase - metabolism AMP-Activated Protein Kinases - metabolism Animals Erythrocytes - metabolism Humans Hypoxia - metabolism Mice Renal Insufficiency, Chronic - metabolism
ISSN:	1533-3450, 1533-3450
On-line prístup:	Zistit podrobnosti o prístupe
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