Amphetamine‐associated seizures: Clinical features and prognosis

Summary Forty‐four patients presenting with first‐ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine‐associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first‐ever seizure patients (provoked n = 126 an...

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Veröffentlicht in:	Epilepsia (Copenhagen) Jg. 52; H. 2; S. 401 - 404
Hauptverfasser:	Brown, J. William L., Dunne, John W., Fatovic, Daniel M., Lee, Judy, Lawn, Nicholas D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Oxford, UK Blackwell Publishing Ltd 01.02.2011 Wiley-Blackwell Wiley Subscription Services, Inc
Schlagworte:	Adolescent Adult Amphetamine Amphetamines Anticonvulsants - therapeutic use Biological and medical sciences Central Nervous System Stimulants Drug abuse EEG Electroencephalography Environmental factors Epilepsy Female Follow-Up Studies Hallucinogens Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Kaplan-Meier Estimate Male MDMA Mechanism Medical research Medical sciences N-Methyl-3,4-methylenedioxyamphetamine Nervous system (semeiology, syndromes) Neuroimaging Neurology Prognosis Recurrence Risk Factors Seizure Seizures Seizures - chemically induced Seizures - classification Seizures - drug therapy Sleep deprivation Status Epilepticus - chemically induced Street Drugs Tumors of the nervous system. Phacomatoses Western Australia Young Adult Western Australia Amphetamine derivatives Recurrence Nervous system diseases Prognosis CNS stimulant Psychotropic Epilepsy Mechanism Cerebral disorder MDMA Amphetamine Convulsion Central nervous system disease Amfetamine Seizure Neurological disorder
ISSN:	0013-9580, 1528-1167, 1528-1167
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Zusammenfassung:	Summary Forty‐four patients presenting with first‐ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine‐associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first‐ever seizure patients (provoked n = 126 and unprovoked n = 401). Cumulative probability of recurrence was calculated using Kaplan‐Meier analysis. Seizure recurrence and development of epilepsy were less likely in patients with AAS compared to provoked or unprovoked controls. Forty percent of patients with AAS had clinical risk factors for epilepsy, epileptiform abnormalities on electroencephalography (EEG), or an epileptogenic lesion on neuroimaging. Sleep deprivation was more frequently present in those with AAS. AAS likely relate to an intrinsic proconvulsant effect of these drugs combined with patient susceptibility and environmental factors.
Bibliographie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0013-9580 1528-1167 1528-1167
DOI:	10.1111/j.1528-1167.2010.02924.x