Amphetamine‐associated seizures: Clinical features and prognosis

Summary Forty‐four patients presenting with first‐ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine‐associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first‐ever seizure patients (provoked n = 126 an...

Full description

Saved in:
Bibliographic Details
Published in:Epilepsia (Copenhagen) Vol. 52; no. 2; pp. 401 - 404
Main Authors: Brown, J. William L., Dunne, John W., Fatovic, Daniel M., Lee, Judy, Lawn, Nicholas D.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011
Wiley-Blackwell
Wiley Subscription Services, Inc
Subjects:
Adolescent
Adult
Amphetamine
Amphetamines
Anticonvulsants - therapeutic use
Biological and medical sciences
Central Nervous System Stimulants
Drug abuse
EEG
Electroencephalography
Environmental factors
Epilepsy
Female
Follow-Up Studies
Hallucinogens
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Kaplan-Meier Estimate
Male
MDMA
Mechanism
Medical research
Medical sciences
N-Methyl-3,4-methylenedioxyamphetamine
Nervous system (semeiology, syndromes)
Neuroimaging
Neurology
Prognosis
Recurrence
Risk Factors
Seizure
Seizures
Seizures - chemically induced
Seizures - classification
Seizures - drug therapy
Sleep deprivation
Status Epilepticus - chemically induced
Street Drugs
Tumors of the nervous system. Phacomatoses
Western Australia
Young Adult
Western Australia
Amphetamine derivatives
Recurrence
Nervous system diseases
Prognosis
CNS stimulant
Psychotropic
Epilepsy
Mechanism
Cerebral disorder
MDMA
Amphetamine
Convulsion
Central nervous system disease
Amfetamine
Seizure
Neurological disorder
ISSN:0013-9580, 1528-1167, 1528-1167
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Forty‐four patients presenting with first‐ever seizure within 24 h of illicit use of amphetamine or related analogs (amphetamine‐associated seizures, AAS) were identified over 8 years. Patients with AAS were compared to control groups of other first‐ever seizure patients (provoked n = 126 and unprovoked n = 401). Cumulative probability of recurrence was calculated using Kaplan‐Meier analysis. Seizure recurrence and development of epilepsy were less likely in patients with AAS compared to provoked or unprovoked controls. Forty percent of patients with AAS had clinical risk factors for epilepsy, epileptiform abnormalities on electroencephalography (EEG), or an epileptogenic lesion on neuroimaging. Sleep deprivation was more frequently present in those with AAS. AAS likely relate to an intrinsic proconvulsant effect of these drugs combined with patient susceptibility and environmental factors.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
ISSN:0013-9580
1528-1167
1528-1167
DOI:10.1111/j.1528-1167.2010.02924.x