Platelet and endothelial cell P‐selectin are required for host defense against Klebsiella pneumoniae‐induced pneumosepsis

Summary Background Sepsis is associated with activation of platelets and endothelial cells accompanied by enhanced P‐selectin surface expression. Both platelet‐ and endothelial P‐selectin have been associated with leukocyte recruitment and induction of inflammatory alterations. Klebsiella (K.) pneum...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 13; no. 6; pp. 1128 - 1138
Main Authors:	Stoppelaar, S. F., Veer, C., Roelofs, J. J. T. H., Claushuis, T. A. M., Boer, O. J., Tanck, M. W. T., Hoogendijk, A. J., Poll, T.
Format:	Journal Article
Language:	English
Published:	England Elsevier Limited 01.06.2015
Subjects:	Animals Bacterial Load Blood Coagulation Blood Platelets - immunology Blood Platelets - metabolism Blood Platelets - microbiology Bone Marrow Transplantation Chemotaxis, Leukocyte Cytokines - blood Disease Models, Animal Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - microbiology endothelium Host-Pathogen Interactions Immunity, Innate Inflammation Mediators - blood Klebsiella Infections - genetics Klebsiella Infections - immunology Klebsiella Infections - metabolism Klebsiella Infections - microbiology Klebsiella pneumoniae - growth & development Klebsiella pneumoniae - immunology Klebsiella pneumoniae - pathogenicity Lung - immunology Lung - metabolism Lung - microbiology Mice, Inbred C57BL Mice, Knockout P-Selectin - genetics P-Selectin - metabolism Platelet Activation platelets pneumonia Pneumonia, Bacterial - genetics Pneumonia, Bacterial - immunology Pneumonia, Bacterial - metabolism Pneumonia, Bacterial - microbiology Protective Factors P‐selectin sepsis Sepsis - genetics Sepsis - immunology Sepsis - metabolism Sepsis - microbiology Signal Transduction Time Factors endothelium pneumonia P-selectin platelets sepsis
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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