Remineralization of deep enamel dentine caries lesions

Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced...

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Vydáno v:	Australian dental journal Ročník 53; číslo 3; s. 281 - 285
Hlavní autor:	Ten Cate, JM
Médium:	Journal Article Konferenční příspěvek
Jazyk:	angličtina
Vydáno:	Oxford, UK Blackwell Publishing Ltd 01.09.2008 Wiley-Blackwell
Témata:	Biological and medical sciences bisphosphonate Bones, joints and connective tissue. Antiinflammatory agents Calcium - therapeutic use Calcium Phosphates - metabolism Cariostatic Agents - therapeutic use Chemical Precipitation Computer Simulation Crystallization Dental Caries - drug therapy Dentin - pathology Dentin Permeability dentine Diffusion Diphosphonates - therapeutic use fluoride Fluorides - therapeutic use Humans Medical sciences Microradiography minimal intervention dentistry Pharmacology. Drug treatments Remineralization Time Factors Tooth Remineralization Dentin Antiosteoporotic fluoride minimal intervention dentistry Dentistry Fluorides Bisphosphonates Tooth enamel Antiosteoclastic agent dentine bisphosphonate Lesion Remineralization
ISSN:	0045-0421, 1834-7819
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Abstract	Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications.
AbstractList	Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications. Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications. Enamel remineralization is generally studied in superficial (up to 100 mu m) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications. Enamel remineralization is generally studied in superficial (up to 100 mum) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications.Enamel remineralization is generally studied in superficial (up to 100 mum) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications. Enamel remineralization is generally studied in superficial (up to 100 mum) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications.
Author	Ten Cate, JM
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Cites_doi	10.1016/0003-9969(79)90057-8 10.1177/00220345860650010201 10.1159/000128561 10.1177/08959374940080020201 10.1177/154405910408301S08 10.1159/000061639 10.1159/000260667 10.14219/jada.archive.1998.0104 10.1074/jbc.M314114200 10.1159/000016496 10.1159/000088904 10.1159/000260477 10.1159/000260501 10.1159/000091060 10.1177/154405910408301S16 10.1111/j.1754-4505.1998.tb01353.x 10.1038/189226a0 10.1159/000080585 10.1002/14651858.CD002284 10.1177/00220345010800050401 10.1111/j.1600-0722.2006.00347.x
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Snippet	Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses... Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses... Enamel remineralization is generally studied in superficial (up to 100 mum) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses... Enamel remineralization is generally studied in superficial (up to 100 mu m) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses...
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SubjectTerms	Biological and medical sciences bisphosphonate Bones, joints and connective tissue. Antiinflammatory agents Calcium - therapeutic use Calcium Phosphates - metabolism Cariostatic Agents - therapeutic use Chemical Precipitation Computer Simulation Crystallization Dental Caries - drug therapy Dentin - pathology Dentin Permeability dentine Diffusion Diphosphonates - therapeutic use fluoride Fluorides - therapeutic use Humans Medical sciences Microradiography minimal intervention dentistry Pharmacology. Drug treatments Remineralization Time Factors Tooth Remineralization
Title	Remineralization of deep enamel dentine caries lesions
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