Remineralization of deep enamel dentine caries lesions

Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced...

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Veröffentlicht in:Australian dental journal Jg. 53; H. 3; S. 281 - 285
1. Verfasser: Ten Cate, JM
Format: Journal Article Tagungsbericht
Sprache:Englisch
Veröffentlicht: Oxford, UK Blackwell Publishing Ltd 01.09.2008
Wiley-Blackwell
Schlagworte:
Biological and medical sciences
bisphosphonate
Bones, joints and connective tissue. Antiinflammatory agents
Calcium - therapeutic use
Calcium Phosphates - metabolism
Cariostatic Agents - therapeutic use
Chemical Precipitation
Computer Simulation
Crystallization
Dental Caries - drug therapy
Dentin - pathology
Dentin Permeability
dentine
Diffusion
Diphosphonates - therapeutic use
fluoride
Fluorides - therapeutic use
Humans
Medical sciences
Microradiography
minimal intervention dentistry
Pharmacology. Drug treatments
Remineralization
Time Factors
Tooth Remineralization
Dentin
Antiosteoporotic
fluoride
minimal intervention dentistry
Dentistry
Fluorides
Bisphosphonates
Tooth enamel
Antiosteoclastic agent
dentine
bisphosphonate
Lesion
Remineralization
ISSN:0045-0421, 1834-7819
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Beschreibung
Zusammenfassung:Enamel remineralization is generally studied in superficial (up to 100 μm) lesions, but in vivo caries lesions may be tenfold deeper. This article addresses the question whether deep lesions, and extending into dentine, can be remineralized under optimal conditions and if this process is influenced by agents affecting calcium phosphate precipitation and dissolution. Lesions through enamel into dentine were first formed in thin sections and then continuously remineralized for periods up to 200 days. With longitudinal assessment by transversal microradiography it was showed that remineralization throughout the depth of the lesion and into the dentine was possible, although this process is very slow. Fluoride and bisphosphonate treatments affected mainly the deposition in the outer enamel. Although it was assumed that this would affect the diffusion of ions to deeper layers, the treatments had no impact on remineralization in the inner enamel or dentinal parts of the lesions. These findings are discussed with relevant theoretical considerations, and in their possible clinical implications.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0045-0421
1834-7819
DOI:10.1111/j.1834-7819.2008.00063.x