Hippocampal cell proliferation regulation by repeated stress and antidepressants

A recent hypothesis suggests reduced hippocampal neurogenesis in depression. Here, we examined cell proliferation in the dentate gyrus and the subventricular zone of rats given repeated stress, a paradigm that prolongs learned helplessness behavior, and whether antidepressants modulate the learned h...

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Bibliographic Details
Published in:Neuroreport Vol. 17; no. 9; p. 863
Main Authors: Chen, Hu, Pandey, Ghanshyam N, Dwivedi, Yogesh
Format: Journal Article
Language:English
Published: England 26.06.2006
Subjects:
Analysis of Variance
Animals
Antidepressive Agents - administration & dosage
Antidepressive Agents - pharmacology
Behavior, Animal
Bromodeoxyuridine - metabolism
Cell Count - methods
Cell Proliferation - drug effects
Corticosterone - metabolism
Desipramine - administration & dosage
Desipramine - pharmacology
Electroshock - adverse effects
Fluoxetine - administration & dosage
Fluoxetine - pharmacology
Helplessness, Learned
Hippocampus - cytology
Immunohistochemistry - methods
Male
Neurons - drug effects
Radioimmunoassay - methods
Rats
Rats, Sprague-Dawley
Stress, Psychological - complications
Stress, Psychological - drug therapy
Stress, Psychological - etiology
Stress, Psychological - pathology
ISSN:0959-4965
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Summary:A recent hypothesis suggests reduced hippocampal neurogenesis in depression. Here, we examined cell proliferation in the dentate gyrus and the subventricular zone of rats given repeated stress, a paradigm that prolongs learned helplessness behavior, and whether antidepressants modulate the learned helplessness-associated altered cell proliferation. Decreased cell proliferation, number of clusters, and cells/cluster were noted in the dentate gyrus, but not in the subventricular zone, of learned helplessness rats. Both fluoxetine and desipramine reversed the learned helplessness behavior and increased the cell proliferation and the number of clusters in learned helplessness rats; only fluoxetine did so significantly. Both fluoxetine and desipramine significantly increased the number of cells/cluster. Our results suggest modified hippocampal neurogenesis in prolonged depression and in the mechanism of antidepressant action.
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ISSN:0959-4965
DOI:10.1097/01.wnr.0000221827.03222.70