Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects

OBJECTIVE: Niacin therapy fails to reduce cardiovascular events in statin-treated subjects even though it increases plasma HDL-C (HDL [high-density lipoprotein] cholesterol) and decreases LDL-C (LDL [low-density lipoprotein] cholesterol) and triglyceride levels. To investigate potential mechanisms f...

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Bibliographic Details
Published in:	Arteriosclerosis, thrombosis, and vascular biology Vol. 41; no. 8; p. 2330
Main Authors:	Ronsein, Graziella E, Vaisar, Tomas, Davidson, W Sean, Bornfeldt, Karin E, Probstfield, Jeffrey L, O'Brien, Kevin D, Zhao, Xue-Qiao, Heinecke, Jay W
Format:	Journal Article
Language:	English
Published:	United States 01.08.2021
Subjects:	Adult Atherosclerosis - blood Atherosclerosis - drug therapy Cardiotonic Agents - pharmacology Cardiotonic Agents - therapeutic use Cardiovascular Diseases - blood Cardiovascular Diseases - prevention & control Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Lipoproteins, HDL - blood Lipoproteins, HDL - chemistry Male Middle Aged Niacin - pharmacology Niacin - therapeutic use Proteomics atherosclerosis cardioprotection clusterin high-density lipoprotein metabolism lipid metabolism
ISSN:	1524-4636, 1524-4636
Online Access:	Get more information
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