Statistical Properties of the Branch-Site Test of Positive Selection

The branch-site test is a likelihood ratio test to detect positive selection along prespecified lineages on a phylogeny that affects only a subset of codons in a protein-coding gene, with positive selection indicated by accelerated nonsynonymous substitutions (with ω = dN/dS > 1). This test may h...

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Bibliographic Details
Published in:	Molecular biology and evolution Vol. 28; no. 3; pp. 1217 - 1228
Main Authors:	Yang, Ziheng, dos Reis, Mario
Format:	Journal Article
Language:	English
Published:	United States Society for Molecular Biology and Evolution 01.03.2011 Oxford University Press
Subjects:	Animals Codon Computer simulation Computer Simulation - statistics & numerical data Evolution, Molecular Genes Genome Genomics - statistics & numerical data Humans Likelihood Functions Models, Genetic Molecular biology Mutation Open Reading Frames - genetics Phylogenetics Phylogeny Proteins Selection, Genetic Sequence Alignment likelihood ratio test positive selection codon model branch-site test
ISSN:	0737-4038, 1537-1719, 1537-1719
Online Access:	Get full text
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