The role of proximal-enhancer elements in the glucocorticoid regulation of carbamoylphosphate synthetase gene transcription from the upstream response unit

As part of the urea cycle, carbamoylphosphate synthetase (CPS) converts toxic ammonia resulting from amino-acid catabolism into urea. Liver-specific and glucocorticoid-dependent expression of the gene involves a distal enhancer, a promoter-proximal enhancer, and the minimal promoter itself. When cha...

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Vydáno v:	Biochimie Ročník 87; číslo 11; s. 1033 - 1040
Hlavní autoři:	Schoneveld, Onard J.L.M., Gaemers, Ingrid C., Hoogenkamp, Maarten, Lamers, Wouter H.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	France Elsevier Masson SAS 01.11.2005
Témata:	Animals Base Sequence Carbamoyl-Phosphate Synthase (Ammonia) - biosynthesis Carbamoylphosphate synthetase CCAAT-Enhancer-Binding Proteins - genetics Cercopithecus aethiops COS Cells Distal enhancer Electrophoretic Mobility Shift Assay Enhancer Elements, Genetic - physiology GAGA-box Gene Expression Regulation, Enzymologic - genetics Glucocorticoid-responsive element Glucocorticoid-responsive unit Glucocorticoids - pharmacology Liver Neoplasms, Experimental Models, Genetic Molecular Sequence Data Proximal enhancer Rats Receptors, Glucocorticoid - metabolism Transcription, Genetic - physiology Transcriptional Activation Transfection Tumor Cells, Cultured GAGA-box Carbamoylphosphate synthetase Distal enhancer Glucocorticoid-responsive element Glucocorticoid-responsive unit Proximal enhancer
ISSN:	0300-9084, 1638-6183
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