Segmentation of thalamic nuclei using a modified k-means clustering algorithm and high-resolution quantitative magnetic resonance imaging at 1.5 T

Patient outcome in minimally invasive stereotactic neurosurgical procedures depends on the ability to accurately locate the desired functional region within the deep brain while avoiding the surrounding anatomy. Due to the lack of sufficient contrast within this region in pre-operatively acquired MR...

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Vydáno v:NeuroImage (Orlando, Fla.) Ročník 34; číslo 1; s. 117 - 126
Hlavní autoři: Deoni, Sean C.L., Rutt, Brian K., Parrent, Andrew G., Peters, Terry M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 2007
Elsevier Limited
Témata:
Adult
Algorithms
Brain
Female
Humans
Image segmentation
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Male
Medical research
NMR
Nuclear magnetic resonance
Quantitative magnetic resonance imaging
Thalamic nuclei
Thalamic Nuclei - anatomy & histology
Thalamic Nuclei - physiology
Quantitative magnetic resonance imaging
Thalamic nuclei
Image segmentation
T 1
T 2
ISSN:1053-8119, 1095-9572
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Shrnutí:Patient outcome in minimally invasive stereotactic neurosurgical procedures depends on the ability to accurately locate the desired functional region within the deep brain while avoiding the surrounding anatomy. Due to the lack of sufficient contrast within this region in pre-operatively acquired MR images, electrophysiological exploration and histological atlases are currently required to define the surgical target within the thalamus in the treatment of many motor-control disorders. In this paper we introduce a method for segmenting the individual thalamic nuclei based on high-resolution quantitative magnetic resonance images, providing improved target visualization. The method was tested using whole-brain T 1 and T 2 data acquired from four healthy individuals. Accuracy of the segmentation results was assessed by comparing the center-of-mass coordinates of the segmented nuclei, with coordinates obtained from a classic histological atlas registered to these images. Strong agreement was found, with an average Euclidean distance difference of less than 4.5 mm averaged across all nuclei and all individuals. Reproducibility of the method, determined by calculating the percent similarity of segmentation results derived from data acquired from repeated scan sessions, was greater than 85%. These results illustrate the ability to accurately and reliably segment the primary nuclei of the thalamus and suggest that the method may have utility in the study of individual nuclear regions in disease state as well as for planning deep-brain surgical procedures.
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ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.09.016