Asthma and coagulation
Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and...
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| Vydané v: | Blood Ročník 119; číslo 14; s. 3236 |
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| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
05.04.2012
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| ISSN: | 1528-0020, 1528-0020 |
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| Abstract | Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and platelets in the pathophysiology of asthma has increased considerably. Asthma is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the anticoagulant protein C system and fibrinolysis. Protease-activated receptors have been implicated as the molecular link between coagulation and allergic inflammation in asthma. This review summarizes current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations and identifies new possible targets for asthma treatment. |
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| AbstractList | Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and platelets in the pathophysiology of asthma has increased considerably. Asthma is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the anticoagulant protein C system and fibrinolysis. Protease-activated receptors have been implicated as the molecular link between coagulation and allergic inflammation in asthma. This review summarizes current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations and identifies new possible targets for asthma treatment.Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and platelets in the pathophysiology of asthma has increased considerably. Asthma is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the anticoagulant protein C system and fibrinolysis. Protease-activated receptors have been implicated as the molecular link between coagulation and allergic inflammation in asthma. This review summarizes current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations and identifies new possible targets for asthma treatment. Asthma is a chronic airway disease characterized by paroxysmal airflow obstruction evoked by irritative stimuli on a background of allergic lung inflammation. Currently, there is no cure for asthma, only symptomatic treatment. In recent years, our understanding of the involvement of coagulation and anticoagulant pathways, the fibrinolytic system, and platelets in the pathophysiology of asthma has increased considerably. Asthma is associated with a procoagulant state in the bronchoalveolar space, further aggravated by impaired local activities of the anticoagulant protein C system and fibrinolysis. Protease-activated receptors have been implicated as the molecular link between coagulation and allergic inflammation in asthma. This review summarizes current knowledge of the impact of the disturbed hemostatic balance in the lungs on asthma severity and manifestations and identifies new possible targets for asthma treatment. |
| Author | de Boer, J Daan Majoor, Christof J van der Poll, Tom van 't Veer, Cornelis Bel, Elisabeth H D |
| Author_xml | – sequence: 1 givenname: J Daan surname: de Boer fullname: de Boer, J Daan email: j.d.deboer@amc.uva.nl organization: Academic Medical Center,University of Amsterdam, Center for Experimental and Molecular Medicine, Meibergdreef 9, Amsterdam, The Netherlands. j.d.deboer@amc.uva.nl – sequence: 2 givenname: Christof J surname: Majoor fullname: Majoor, Christof J – sequence: 3 givenname: Cornelis surname: van 't Veer fullname: van 't Veer, Cornelis – sequence: 4 givenname: Elisabeth H D surname: Bel fullname: Bel, Elisabeth H D – sequence: 5 givenname: Tom surname: van der Poll fullname: van der Poll, Tom |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22262775$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Administration, Inhalation Animals Anticoagulants - administration & dosage Anticoagulants - therapeutic use Asthma - complications Asthma - drug therapy Asthma - metabolism Blood Coagulation - physiology Blood Coagulation Disorders - complications Blood Coagulation Disorders - drug therapy Blood Coagulation Disorders - metabolism Blood Coagulation Factors - metabolism Blood Platelets - metabolism Fibrinolysis Heparin - administration & dosage Heparin - therapeutic use Humans Protein C - metabolism Receptor, PAR-2 - metabolism Signal Transduction |
| Title | Asthma and coagulation |
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