Pharmacokinetics in Morbid Obesity: Influence of Two Bariatric Surgery Techniques on Paracetamol and Caffeine Metabolism

Purpose The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). Materials and Methods In the present prospective study, we studied 24 morb...

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Bibliographic Details
Published in:Obesity surgery Vol. 27; no. 12; pp. 3194 - 3201
Main Authors: Goday Arno, Albert, Farré, Magí, Rodríguez-Morató, Jose, Ramon, Jose M., Pérez-Mañá, Clara, Papaseit, Esther, Civit, Ester, Langohr, Klaus, lí Carbó, Marcel, Boix, David Benaiges, Nino, Olga Castañer, Le Roux, Juana Antonia Flores, Pera, Manuel, Grande, Luis, de la Torre, Rafael
Format: Journal Article Publication
Language:English
Published: New York Springer US 01.12.2017
Springer Nature B.V
Subjects:
05 Combinatorics
05B Designs and configurations
60 Probability theory and stochastic processes
60C05 Combinatorial probability
92 Biology and other natural sciences
92B Mathematical biology in general
Acetaminophen - pharmacokinetics
Adolescent
Adult
Analgesics
Bariatric Surgery - adverse effects
Bariatric Surgery - methods
Bioavailability
Biomarkers - blood
Biomatemàtica
Biomathematics
Caffeine
Caffeine - pharmacokinetics
Classificació AMS
Clinical trial
Combinatorial analysis
Combinatorial probabilities
Combinatòria
Female
Gastrectomy - adverse effects
Gastrectomy - methods
Gastric bypass
Gastric Bypass - adverse effects
Gastric Bypass - methods
Gastrointestinal surgery
Humans
Inactivation, Metabolic - physiology
Male
Matemàtica aplicada a les ciències
Matemàtiques i estadística
Medicine
Medicine & Public Health
Metabolism
Metabolism paracetamol
Middle Aged
Morbid obesity
Obesity
Obesity, Morbid - metabolism
Obesity, Morbid - surgery
Original Contributions
Pharmacokinetics
Pharmacology
Probabilitat
Probabilitats
Sleeve gastrectomy
Surgery
Surgical outcomes
Surgical techniques
Weight Loss - physiology
Young Adult
Àrees temàtiques de la UPC
Paracetamol
Gastric bypass
Clinical trial
Morbid obesity
Metabolism
Sleeve gastrectomy
Caffeine
ISSN:0960-8923, 1708-0428, 1708-0428
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Summary:Purpose The purpose of the study was to study the impact of the two most common bariatric surgery techniques on paracetamol pharmacokinetics (a marker of gastric emptying) and caffeine metabolism (a marker of liver function). Materials and Methods In the present prospective study, we studied 24 morbid obese patients before, at 4 weeks, and 6 months after having undergone sleeve gastrectomy ( n  = 10) or Roux-en-Y gastric bypass ( n  = 14). For comparative purposes, 28 healthy controls (14 normal weights and 14 overweights) were also included in the study. Results Paracetamol pharmacokinetics was altered in the obese participants leading to lower bioavailability. Bariatric surgery resulted in faster absorption and normalized pharmacokinetic parameters, prompting an increase in paracetamol bioavailability. No differences were found between surgical procedures. In the case of caffeine, the ratio paraxanthine/caffeine did not differ between morbid obese and healthy individuals. This ratio remained unmodified after surgery, indicating that the liver function (assessed by cytochrome P450 1A2 activity) was unaffected by obesity or bariatric surgery. Conclusions Paracetamol pharmacokinetics and caffeine plasma levels are altered in severely obese patients. The two studied bariatric surgical techniques normalize paracetamol oral bioavailability without impairing the liver function (measured by cytochrome P450 1A2 activity).
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ISSN:0960-8923
1708-0428
1708-0428
DOI:10.1007/s11695-017-2745-z