Mammalian life depends on two distinct pathways of DNA damage tolerance

DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of life, yet its relevance in mammals remains unclear...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 120; H. 4; S. e2216055120
Hauptverfasser:	Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 24.01.2023
Schlagworte:	Animals DNA Damage DNA Repair DNA Replication Hematopoietic Stem Cells - metabolism Mammals - metabolism Proliferating Cell Nuclear Antigen - metabolism Ubiquitination erythropoiesis embryonic lethality hematopoietic stem cells DNA damage tolerance (DDT) DNA damage response (DDR)
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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