Mammalian life depends on two distinct pathways of DNA damage tolerance

DNA damage threatens genomic integrity and instigates stem cell failure. To bypass genotoxic lesions during replication, cells employ DNA damage tolerance (DDT), which is regulated via PCNA ubiquitination and REV1. DDT is conserved in all domains of life, yet its relevance in mammals remains unclear...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 120; no. 4; p. e2216055120
Main Authors:	Buoninfante, Olimpia Alessandra, Pilzecker, Bas, Spanjaard, Aldo, de Groot, Daniël, Prekovic, Stefan, Song, Ji-Ying, Lieftink, Cor, Ayidah, Matilda, Pritchard, Colin E J, Vivié, Judith, Mcgrath, Kathleen E, Huijbers, Ivo J, Philipsen, Sjaak, von Lindern, Marieke, Zwart, Wilbert, Beijersbergen, Roderick L, Palis, James, van den Berk, Paul C M, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	United States 24.01.2023
Subjects:	Animals DNA Damage DNA Repair DNA Replication Hematopoietic Stem Cells - metabolism Mammals - metabolism Proliferating Cell Nuclear Antigen - metabolism Ubiquitination erythropoiesis embryonic lethality hematopoietic stem cells DNA damage tolerance (DDT) DNA damage response (DDR)
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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