Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

Loss of kidney function in renal ischemia/reperfusion injury is due to programmed cell death, but the contribution of necroptosis, a newly discovered form of programmed necrosis, has not been evaluated. Here, we identified the presence of death receptor–mediated but caspase-independent cell death in...

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Vydáno v:	Kidney international Ročník 81; číslo 8; s. 751 - 761
Hlavní autoři:	Linkermann, Andreas, Bräsen, Jan H., Himmerkus, Nina, Liu, Shuya, Huber, Tobias B., Kunzendorf, Ulrich, Krautwald, Stefan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Basingstoke Elsevier Inc 01.04.2012 Nature Publishing Group Elsevier Limited
Témata:	Animals Apoptosis Biological and medical sciences Cardiology. Vascular system Caspase Inhibitors cell death Cell Line Cysteine Proteinase Inhibitors - pharmacology Humans Imidazoles - pharmacology Indoles - pharmacology ischemia ischemia–reperfusion ischemic renal failure Jurkat Cells Kidney - enzymology Kidney - injuries Kidney - pathology Kidney Tubules, Proximal - drug effects Kidney Tubules, Proximal - enzymology Kidney Tubules, Proximal - pathology Male Medical sciences Mice Mice, Inbred C57BL Necrosis Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Oligopeptides - pharmacology Protein Kinase Inhibitors - pharmacology Receptor-Interacting Protein Serine-Threonine Kinases - antagonists & inhibitors Receptor-Interacting Protein Serine-Threonine Kinases - physiology Renovascular diseases Reperfusion Injury - enzymology Reperfusion Injury - etiology Reperfusion Injury - pathology tubule cells cell death tubule cells ischemia–reperfusion ischemia ischemic renal failure Kidney disease Nephrology Urinary system disease Enzyme Transferases Ischemia reperfusion Non-specific serine/threonine protein kinase Cardiovascular disease Kidney Urology Vascular disease Renal tubule Urinary system Cell death Renal failure ischemia―reperfusion Receptor protein Renal ischemia reperfusion injury Apoptosis
ISSN:	0085-2538, 1523-1755, 1523-1755
On-line přístup:	Získat plný text
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