Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys

Objective Levodopa, the gold standard for Parkinson's disease treatment, is associated with debilitating abnormal involuntary movements or dyskinesias, for which few treatments are currently available. Studies have implicated numerous neurotransmitters in the development of levodopa‐induced dys...

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Veröffentlicht in:	Annals of neurology Jg. 62; H. 6; S. 588 - 596
Hauptverfasser:	Quik, Maryka, Cox, Heather, Parameswaran, Neeraja, O'Leary, Kathryn, Langston, J. William, Di Monte, Donato
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.12.2007 Willey-Liss
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Animals Biological and medical sciences Circadian Rhythm Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug toxicity and drugs side effects treatment Dyskinesia, Drug-Induced - pathology Dyskinesia, Drug-Induced - physiopathology Levodopa - pharmacology Medical sciences Neurology Nicotine - pharmacology Nicotinic Agonists - pharmacology Parkinsonian Disorders - physiopathology Pharmacology. Drug treatments Saimiri Substantia Nigra - pathology Time Factors Toxicity: nervous system and muscle Nervous system diseases Monkey Involuntary movement Cerebral disorder Vertebrata Mammalia Animal Central nervous system disease Primates Levodopa Neurological disorder Extrapyramidal syndrome Dyskinesia Nicotine
ISSN:	0364-5134, 1531-8249, 1531-8249
Online-Zugang:	Volltext
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