Sequence-dependent effects of hematoporphyrin derivatives (HPD) photodynamic therapy and cisplatin on lung adenocarcinoma cells

•The order of the combination therapy (PDT + DDP / DDP + PDT) was important.•The cell viability in the PDT+DDP (HPD-PDT followed by DDP) group was significantly lower than that in the DDP+PDT (DDP followed by HPD-PDT) group.•A significant apoptotic profile and a high apoptotic rate were found in the...

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Bibliographic Details
Published in:	Photodiagnosis and photodynamic therapy Vol. 47; p. 104102
Main Authors:	Li, Nana, Cui, Shichao, Yang, Aizhen, Xiao, Baohong, Cao, Yiwei, Yang, Xiaohui, Lin, Cunzhi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.06.2024
Subjects:	A549 Cells Adenocarcinoma - drug therapy Adenocarcinoma of Lung - drug therapy Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Survival - drug effects Cisplatin Cisplatin - pharmacology Combined therapy Hematoporphyrin Derivative - pharmacology Hematoporphyrin derivatives Hematoporphyrins - pharmacology Humans Lung Neoplasms - drug therapy Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Hematoporphyrin derivatives Photodynamic therapy Combined therapy Cisplatin Apoptosis
ISSN:	1572-1000, 1873-1597, 1873-1597
Online Access:	Get full text
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