Senescence and the SASP: many therapeutic avenues

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and li...

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Vydané v:	Genes & development Ročník 34; číslo 23-24; s. 1565
Hlavní autori:	Birch, Jodie, Gil, Jesús
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.12.2020
Predmet:	Aging - genetics Aging - pathology Cellular Senescence - genetics Disease Susceptibility - therapy Drug Development Drug Therapy Epigenesis, Genetic Gene Expression Regulation Humans Pharmaceutical Preparations - chemistry Secretory Pathway Signal Transduction senescence therapeutics disease inflammation senolytics cancer aging SASP senomorphics
ISSN:	1549-5477, 1549-5477
On-line prístup:	Zistit podrobnosti o prístupe
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