Endoplasmic reticulum stress in disease pathogenesis

The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including...

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Bibliographic Details

Published in:	Annual review of pathology Vol. 3; p. 399
Main Authors:	Lin, Jonathan H, Walter, Peter, Yen, T S Benedict
Format:	Journal Article
Language:	English
Published:	United States 01.01.2008
Subjects:	Animals Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - ultrastructure Humans Metabolism, Inborn Errors - etiology Protein Folding Signal Transduction - physiology Stress, Physiological - metabolism
ISSN:	1553-4006
Online Access:	Get more information
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