Ultrasensitive DNA chip: gene expression profile analysis without RNA amplification

We have developed a new DNA chip whose substrate has a unique minute columnar array structure made of plastic. The DNA chip exhibits ultrahigh sensitivity, up to 100-fold higher than that of reference DNA chips, which makes it possible to monitor gene expression profiles even with very small amounts...

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Bibliographic Details

Published in:	Journal of biochemistry (Tokyo) Vol. 139; no. 4; p. 697
Main Authors:	Nagino, Kunihisa, Nomura, Osamu, Takii, Yuki, Myomoto, Akira, Ichikawa, Makiko, Nakamura, Fumio, Higasa, Masashi, Akiyama, Hideo, Nobumasa, Hitoshi, Shiojima, Satoshi, Tsujimoto, Gozoh
Format:	Journal Article
Language:	English
Published:	England 01.04.2006
Subjects:	Gene Expression Profiling - instrumentation Gene Expression Profiling - methods Microscopy, Electron, Scanning Nucleic Acid Amplification Techniques - methods Nucleic Acid Hybridization - methods Oligonucleotide Array Sequence Analysis - instrumentation Oligonucleotide Array Sequence Analysis - methods Plasminogen Activators - genetics Reproducibility of Results Reverse Transcriptase Polymerase Chain Reaction - methods RNA - genetics RNA - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Statistics, Nonparametric
ISSN:	0021-924X
Online Access:	Get more information
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